Product image of Lecisyn (Levocetirizine Dihydrochloride) supplied by GNH India

Lecisyn

Active Ingredient:
Levocetirizine Dihydrochloride
Origin:
EU

Lecisyn (Levocetirizine Dihydrochloride)

Levocetirizine, the active ingredient in Lecisyn, is an antihistamine presented as an oral tablet for oral use. It selectively blocks peripheral H1 receptors to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria in adults and children when appropriate. The medication is formulated for rapid absorption and is commonly prescribed for seasonal and perennial allergy symptoms.

GNH India supplies Lecisyn as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and healthcare institutions worldwide and regulatory compliant across multiple regions.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Levocetirizine is used to manage allergic conditions by antagonizing histamine activity.
  • Allergic rhinitis: reduces nasal congestion, itching, sneezing and watery discharge.
  • Chronic idiopathic urticaria: alleviates wheals and itching associated with chronic hives.
  • Seasonal allergic rhinitis: provides symptom relief during pollen seasons.

How It Works

  • Levocetirizine acts as a selective peripheral H1‑receptor antagonist. By binding to the histamine H1 receptors on mast cells, basophils and other target cells, it prevents histamine from triggering the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation, thereby reducing the classic signs of allergic inflammation.

Side Effects

Levocetirizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or mild sedation
  • Dry mouth
  • Headache
  • Fatigue
  • Nausea
  • Altered taste perception

Serious or Rare Side Effects

  • Angioedema or severe swelling of face, lips or throat
  • Anaphylactic reactions
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hepatic dysfunction
  • Hematologic abnormalities such as neutropenia
  • Severe skin rash or urticaria worsening

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Renal function assessment: adjust dose in patients with impaired renal clearance.
  • Known hypersensitivity: avoid if patient has previous allergic reaction to levocetirizine or other piperazine antihistamines.
  • Sedation risk: caution when operating machinery or driving until individual response is known.
  • Pregnancy and lactation: use only if benefits outweigh potential risks after medical evaluation.
  • Drug interactions: review concomitant medications for additive CNS depression.
  • Store at below 25°C: keep in original packaging, protect from moisture.

Avoid Interactions

Levocetirizine may interact with other medicines; monitoring is advised.

Major Interactions (Avoid)

  • Concurrent use with other H1 antihistamines: may increase risk of sedation and anticholinergic effects.
  • Alcohol or CNS depressants: can potentiate drowsiness.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise plasma levels, though effect is limited.

Moderate Interactions (Monitor Closely)

  • Erythromycin or azithromycin: may modestly increase levocetirizine exposure.
  • Theophylline: monitor for enhanced CNS effects.
  • Cimetidine: may slightly raise levocetirizine concentrations.

Frequently Asked Questions

Lecisyn contains levocetirizine and is prescribed to relieve symptoms of allergic rhinitis, such as sneezing, itching and nasal discharge, as well as to control chronic idiopathic urticaria, reducing wheals and itching associated with persistent hives.

Levocetirizine selectively blocks peripheral H1 histamine receptors, preventing histamine from binding and triggering the cascade that leads to vasodilation, increased vascular permeability, and nerve stimulation, thereby diminishing the typical signs of an allergic response.

The appropriate dose of Lecisyn is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms, renal function and other clinical factors. The prescriber will set the exact regimen for each individual.

Safety data for levocetirizine in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Lecisyn product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levocetirizine is a second‑generation antihistamine offering less sedation than first‑generation agents such as diphenhydramine. Compared with cetirizine, it provides similar efficacy with a slightly lower incidence of drowsiness, making it a preferred option for patients needing daytime symptom control.

Lecisyn tablets should be stored at temperatures below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Do not store in a refrigerator or freezer unless specifically instructed by the supplier.

Lecisyn is taken orally as a tablet. The tablet should be swallowed whole with a glass of water, with or without food, according to the prescriber’s instructions.

Serious adverse reactions, although rare, include angioedema, anaphylaxis, severe skin reactions such as Stevens‑Johnson syndrome, hepatic dysfunction and hematologic abnormalities. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, or unexplained bruising.

Lecisyn should be avoided in individuals with known hypersensitivity to levocetirizine, other piperazine antihistamines, or any of the tablet’s excipients. It is also contraindicated in patients with severe renal impairment unless dose adjustment is made under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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