Lecrolyn Sine (Sodium Cromoglicate)

• Lecrolyn Sine, a mast cell stabilizer, is indicated for ocular allergic conditions that involve mast cell activation.
• Allergic conjunctivitis: reduces itching, redness, and tearing associated with seasonal or perennial allergens.
• Mast cell‑mediated ocular allergy: stabilizes ocular mast cells to prevent inflammatory mediator release.
• Seasonal allergic conjunctivitis: provides symptom relief during pollen seasons.

• Sodium Cromoglicate acts by binding to mast cell membranes and inhibiting calcium influx, which prevents degranulation. This blockade reduces the release of histamine, leukotrienes, prostaglandins, and other inflammatory mediators from ocular mast cells, thereby limiting the allergic inflammatory response on the conjunctival surface. The drug does not affect already released mediators and has minimal systemic absorption when applied topically. Its localized action makes it suitable for long‑term management of chronic ocular allergy without significant systemic effects.

Topical ocular administration of Sodium Cromoglicate may be associated with the following adverse reactions.

Common Side Effects

• Burning or stinging sensation at instillation: usually mild, transient, and resolves within minutes.
• Transient blurred vision: may last a few minutes after dosing and does not affect long‑term acuity.
• Mild eye irritation or redness: typically resolves without additional treatment.
• Temporary foreign body sensation: feels like a grain of sand in the eye and subsides quickly.

Serious or Rare Side Effects

• Allergic contact dermatitis of the eyelid: requires discontinuation and prompt medical evaluation.
• Corneal ulceration: rare but may lead to vision impairment if not treated early.
• Severe eye pain with vision loss: immediate ophthalmic assessment is essential.

When using Lecrolyn Sine, consider the following precautions to ensure safe and effective therapy.

• Hypersensitivity: discontinue if signs of allergic reaction such as eyelid swelling or rash appear.
• Contact lenses: remove lenses before instillation and wait several minutes before reinserting.
• Ocular infection: avoid use if active eye infection is present; treat infection first.
• Concomitant ophthalmic drugs: space dosing intervals of at least 5 minutes when using other eye drops.
• Prescription adherence: use exactly as prescribed and do not exceed recommended frequency.
• Store at room temperature: keep in original container, protect from light and moisture, and do not freeze.

Sodium Cromoglicate may interact with other ophthalmic agents; the following interactions are recognized.

Major Interactions (Avoid)

• Concurrent use with topical ophthalmic anesthetics: may increase corneal toxicity.
• Combination with other mast cell stabilizers: provides no additional benefit and may increase irritation.
• Use with preservative‑rich antihistamine eye drops: may exacerbate ocular surface irritation.

Moderate Interactions (Monitor Closely)

• Co‑administration with corticosteroid eye drops: monitor intraocular pressure for potential elevation.
• Simultaneous use with systemic antihistamines: may enhance overall antiallergic effect, watch for excessive dryness.