Product image of Lecrolyn Sine (Sodium Cromoglicate) supplied by GNH India

Lecrolyn Sine

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Lecrolyn Sine (Sodium Cromoglicate)

Sodium Cromoglicate, the active ingredient in Lecrolyn Sine, is a mast cell stabilizer presented as an ophthalmic solution for ocular use. It helps manage allergic conjunctivitis and other ocular allergy conditions by reducing the release of histamine and inflammatory mediators in the eye, providing relief from itching, redness, and swelling associated with allergic reactions.

GNH India supplies Lecrolyn Sine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Lecrolyn Sine is a mast cell stabilizer indicated for ocular allergy conditions and works by preventing mast‑cell degranulation.

  • Allergic conjunctivitis: reduces ocular itching, redness and swelling by stabilizing mast cells.
  • Seasonal allergic conjunctivitis: provides symptom control during pollen seasons.
  • Vernal keratoconjunctivitis: helps lessen chronic inflammation and discomfort in affected eyes.

How It Works

  • Sodium Cromoglicate stabilizes ocular mast cells and inhibits their degranulation, thereby preventing the release of histamine, leukotrienes, and other inflammatory mediators. By blocking these pathways on the ocular surface, it reduces the cascade of allergic inflammation that leads to itching, redness, and swelling in the conjunctiva.

Side Effects

Common Side Effects

  • Transient burning or stinging sensation upon instillation.
  • Mild ocular irritation or foreign‑body feeling.
  • Temporary blurred vision that resolves quickly.
  • Increased tearing or watery eyes.
  • Mild conjunctival hyperemia.
  • Slight eyelid edema.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema of the eyelid).
  • Persistent eye pain or photophobia.
  • Vision loss or sudden decrease in visual acuity.
  • Corneal ulceration or epithelial defect.
  • Anaphylaxis (extremely rare).
  • Persistent intra‑ocular inflammation.

Precautions & Warnings

Before using Lecrolyn Sine, consider the following precautions:

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Contact lens wearers: remove lenses before instillation and wait several minutes before reinserting.
  • Active ocular infection: avoid use until infection is resolved.
  • Avoid contamination: use single‑dose containers and discard any remaining solution after the recommended period.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Lecrolyn Sine has a limited interaction profile, but the following should be considered.

Major Interactions (Avoid)

  • Concurrent use with ophthalmic solutions containing benzalkonium chloride: may increase ocular irritation.
  • Duplicate therapy with other mast cell stabilizers: avoid overlapping treatment.

Moderate Interactions (Monitor Closely)

  • Combination with topical antihistamine eye drops: monitor for additive dryness.
  • Use with corticosteroid eye drops: watch intra‑ocular pressure.
  • Co‑administration with contact lens cleaning solutions containing preservatives: may cause discomfort.

Frequently Asked Questions

Lecrolyn Sine is an ophthalmic solution containing sodium cromoglicate that is used to treat allergic conjunctivitis and other ocular allergy conditions. It works by stabilizing mast cells on the eye surface, thereby reducing itching, redness, swelling, and watery discharge associated with allergic reactions.

Sodium cromoglicate stabilizes mast cells in the conjunctiva, preventing them from releasing histamine, leukotrienes, and other inflammatory mediators. By blocking this degranulation process, the drug reduces the cascade of allergic inflammation that causes the typical symptoms of ocular allergy.

The dosing regimen for Lecrolyn Sine is determined by the prescribing clinician based on the severity of the allergic eye condition and patient-specific factors. Healthcare providers typically instruct patients on the number of drops per eye and the frequency of administration.

Safety data for sodium cromoglicate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare professional before using Lecrolyn Sine.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Lecrolyn Sine. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lecrolyn Sine (sodium cromoglicate) is a mast cell stabilizer, whereas many alternative eye drops are antihistamines or combination antihistamine‑mast cell stabilizers (e.g., olopatadine). Sodium cromoglicate primarily prevents mast‑cell degranulation, offering a prophylactic approach, while antihistamines provide rapid symptom relief. Choice of therapy depends on patient response, severity of symptoms, and physician preference.

Lecrolyn Sine should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from direct light and moisture, and discard any remaining solution after the recommended period once opened to maintain sterility.

Lecrolyn Sine is administered as eye drops. The patient should wash their hands, tilt the head back, gently pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. After dosing, keep the eyes closed for a few seconds to allow absorption and avoid blinking excessively.

While generally well tolerated, serious risks include severe allergic reactions such as angioedema of the eyelid, persistent eye pain, sudden loss of visual acuity, corneal ulceration, or anaphylaxis. Patients experiencing any of these symptoms should seek immediate medical attention.

Lecrolyn Sine should not be used by individuals with a known hypersensitivity to sodium cromoglicate or any of the formulation excipients. Patients with active ocular infections should defer use until the infection is resolved, and contact lens wearers should follow specific instructions regarding lens removal and reinsertion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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