Product image of Lecrolyn Sine (Sodium Cromoglicate) supplied by GNH India

Lecrolyn Sine

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Lecrolyn Sine (Sodium Cromoglicate)

Sodium cromoglicate, the active ingredient in Lecrolyn Sine, is a mast cell stabilizer presented as eye drops for ocular use. It treats allergic conjunctivitis, ocular itching and redness caused by allergic eye disease, helping to reduce inflammation and discomfort in the eyes, and is approved for prescription use in the European Union.

GNH India supplies Lecrolyn Sine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Lecrolyn Sine, a mast cell stabilizer, acts on allergic eye disease pathways to alleviate symptoms.

  • Allergic conjunctivitis: Reduces ocular inflammation and itching associated with allergic reactions.
  • Ocular itching: Provides relief from itchiness caused by allergic eye disease.
  • Redness due to allergic eye disease: Decreases hyperemia and discomfort in the affected eye.

How It Works

  • Sodium cromoglicate stabilises mast cells in the conjunctival and corneal tissues, inhibiting calcium‑dependent degranulation. By preventing the release of histamine, prostaglandins and other inflammatory mediators, it limits the cascade that leads to vasodilation, itching and redness in the eye. The drug acts locally on ocular surface cells without systemic absorption. This localized action maintains therapeutic effect while minimizing systemic exposure.

Side Effects

Sodium cromoglicate eye drops may cause ocular or systemic reactions, although most patients tolerate the medication well.

Common Side Effects

  • Transient burning or stinging sensation upon instillation
  • Mild eye redness
  • Temporary blurred vision
  • Tear film instability

Serious or Rare Side Effects

  • Allergic contact dermatitis of the eyelid
  • Severe ocular inflammation
  • Vision loss
  • Systemic hypersensitivity reaction

Precautions & Warnings

When prescribing Lecrolyn Sine, consider the following safety measures.

  • Pregnancy: Safety not established; use only if clearly needed.
  • Breastfeeding: Unknown; consider risk vs benefit.
  • Contact lenses: Remove before administration and wait before reinserting.
  • Concurrent ocular infection: Evaluate before use.
  • Allergy to cromoglicate: Contraindicated.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Sodium cromoglicate has a low potential for drug‑drug interactions, but monitor the following.

Major Interactions (Avoid)

  • Concurrent use with ocular prostaglandin analogs may diminish anti‑inflammatory effect.
  • Combination with preservative‑rich eye drops may increase ocular irritation.

Moderate Interactions (Monitor Closely)

  • Use with other mast cell stabilizers may not provide additional benefit.
  • Co‑administration with topical antihistamines may alter symptom control.
  • Systemic antihistamines may affect overall allergic response, requiring clinical observation.

Frequently Asked Questions

Lecrolyn Sine is an ophthalmic solution containing sodium cromoglicate, indicated for the treatment of allergic conjunctivitis, ocular itching and redness caused by allergic eye disease. It works by stabilising mast cells in the eye to reduce inflammation and discomfort.

Sodium cromoglicate stabilises mast cells on the ocular surface, preventing calcium‑dependent degranulation. This blocks the release of histamine, prostaglandins and other inflammatory mediators, thereby reducing vasodilation, itching and redness associated with allergic eye reactions.

The dosing regimen for Lecrolyn Sine is determined by the prescribing clinician based on the severity of the allergic eye condition, patient age and response to therapy. The prescriber will provide specific instructions on the number of drops and frequency of administration.

Safety data for sodium cromoglicate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order Lecrolyn Sine, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lecrolyn Sine contains sodium cromoglicate, a mast cell stabiliser, whereas many alternative eye drops use antihistamines or non‑steroidal anti‑inflammatory agents. Sodium cromoglicate works upstream by preventing mediator release, offering a different safety profile and may be preferred when a non‑sedating, locally acting option is desired.

Lecrolyn Sine should be stored at room temperature, below 25 °C, in its original container. Protect the bottle from direct light and moisture, and keep the cap tightly closed when not in use to maintain product stability.

The product is supplied as sterile eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. The eyes should be closed gently for a few seconds to allow absorption.

Serious but rare risks include allergic contact dermatitis of the eyelid, severe ocular inflammation, vision loss, and systemic hypersensitivity reactions. Patients should seek immediate medical attention if they experience significant swelling, pain, visual changes or systemic allergic symptoms.

Lecrolyn Sine is contraindicated in individuals with a known hypersensitivity to sodium cromoglicate or any of the formulation excipients. It should also be avoided in patients with active ocular infections until the infection is adequately treated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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