Lecrolyn Sine (Sodium Cromoglicate)

• Lecrolyn Sine, a mast cell stabilizer, is used to treat ocular allergic conditions.
• Allergic conjunctivitis: reduces ocular redness, swelling, and itching associated with allergic inflammation.
• Ocular itching: relieves itching caused by seasonal allergens by stabilizing mast cells on the ocular surface.
• Seasonal allergic eye disease: prevents release of histamine and other mediators, decreasing symptoms during pollen seasons.

• Sodium cromoglicate stabilizes mast cells on the ocular surface by inhibiting calcium influx, which blocks degranulation and the subsequent release of histamine, leukotrienes, and other inflammatory mediators. This action reduces allergic inflammation and alleviates ocular symptoms without systemic immunosuppression.

Lecrolyn Sine is generally well tolerated, but ocular administration can produce local reactions.

Common Side Effects

• Burning or stinging sensation upon instillation
• Transient blurred vision
• Mild eye irritation or redness
• Foreign body sensation
• Temporary tearing
• Slight discomfort that resolves within minutes

Serious or Rare Side Effects

• Allergic reaction with swelling of the eyelids
• Severe eye pain or photophobia
• Corneal ulceration or keratitis
• Sudden loss of vision
• Anaphylaxis (extremely rare)

• Before using Lecrolyn Sine, consider the following precautions.
• Avoid use in patients with known hypersensitivity to sodium cromoglicate or any excipients.
• Discontinue if severe irritation or allergic reaction occurs.
• Consult an ophthalmologist before use in contact lens wearers.
• Do not use if the sterility of the product is compromised.
• Keep the dropper tip clean; avoid touching the eye or surrounding tissues.
• Store at room temperature: keep in the original container, protect from moisture and direct light.

Lecrolyn Sine may interact with other ocular medications; monitor for potential effects.

Major Interactions (Avoid)

• Concurrent use with ophthalmic anesthetics that may increase corneal irritation.
• Simultaneous administration with preservative‑containing eye drops that could exacerbate toxicity.

Moderate Interactions (Monitor Closely)

• Use with other mast cell stabilizers may reduce overall efficacy; space administrations by at least 5 minutes.
• Antihistamine eye drops may alter symptom control; assess patient response.
• Systemic antihistamines generally have minimal impact but should be reviewed for overall allergy management.