Product image of Lecrolyn Sine (Sodium Cromoglicate) supplied by GNH India

Lecrolyn Sine

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Lecrolyn Sine (Sodium Cromoglicate)

Sodium Cromoglicate, the active ingredient in Lecrolyn Sine, is a mast cell stabilizer presented as an ophthalmic solution for ocular use. It is employed to manage allergic conjunctivitis, ocular itching and other mast cell‑mediated eye inflammation in both adults and children.

GNH India supplies Lecrolyn Sine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

  • Sodium Cromoglicate is used to treat ocular allergic conditions by stabilizing mast cells and preventing mediator release.
  • Allergic conjunctivitis: reduces redness, itching and swelling of the conjunctiva.
  • Ocular itching: relieves itch associated with allergic eye disease.
  • Mast cell‑mediated ocular inflammation: controls inflammation and helps prevent symptom recurrence.

How It Works

  • Sodium Cromoglicate binds to calcium channels on mast cells, inhibiting calcium influx that is required for degranulation. By preventing mast cell activation, it blocks the release of histamine, leukotrienes and other inflammatory mediators, thereby reducing allergic inflammation in the ocular surface.

Side Effects

Adverse reactions are generally mild and related to local ocular irritation.

Common Side Effects

  • Transient eye burning or stinging on instillation.
  • Mild ocular redness or hyperemia.
  • Blurred vision that resolves quickly.
  • Foreign‑body sensation.
  • Temporary tearing.

Serious or Rare Side Effects

  • Allergic reaction with eyelid swelling or angioedema.
  • Severe eye pain or corneal ulceration.
  • Vision loss.
  • Anaphylaxis (extremely rare).
  • Persistent intraocular inflammation.

Precautions & Warnings

  • Before prescribing Lecrolyn Sine, clinicians should consider several safety aspects.
  • Assess patient history: confirm diagnosis of allergic ocular disease.
  • Avoid use in patients with known hypersensitivity to sodium cromoglicate.
  • Do not use with contact lenses unless advised by an eye care professional.
  • Monitor for worsening symptoms; discontinue if severe irritation occurs.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Sodium Cromoglicate may interact with other ophthalmic agents; awareness of potential interactions helps maintain safety.

Major Interactions (Avoid)

  • Concurrent use with ocular anesthetics may increase corneal toxicity.
  • Co‑administration with other mast cell stabilizers offers no added benefit.
  • Use with preservative‑containing drops may heighten irritation.

Moderate Interactions (Monitor Closely)

  • Antihistamine eye drops may reduce overall efficacy.
  • Systemic antihistamines might lessen ocular response.
  • Combined use with topical steroids could raise intra‑ocular pressure risk.

Frequently Asked Questions

Lecrolyn Sine contains sodium cromoglicate, a mast cell stabilizer indicated for the treatment of allergic conjunctivitis, ocular itching and other mast cell‑mediated eye inflammation. It helps reduce redness, swelling and discomfort caused by allergic reactions in the eye.

Sodium cromoglicate blocks calcium entry into mast cells, preventing their degranulation. This inhibition stops the release of histamine, leukotrienes and other inflammatory mediators, thereby reducing the allergic response and associated symptoms on the ocular surface.

The dosing regimen for Lecrolyn Sine is determined by the prescribing clinician based on the patient’s age, severity of symptoms and response to therapy. The prescriber will specify the number of drops, frequency and duration of treatment.

Safety data for sodium cromoglicate in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against any possible risks and consider alternative therapies if safety cannot be assured. Consultation with a specialist is recommended.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Compared with antihistamine eye drops, sodium cromoglicate acts upstream by stabilizing mast cells rather than blocking histamine receptors. This can provide longer‑lasting control of inflammation, especially in chronic or seasonal allergy cases, though it may act more slowly to relieve symptoms.

Lecrolyn Sine should be stored at room temperature, below 25 °C, in its original packaging. Protect the bottle from direct sunlight, moisture and extreme temperature fluctuations to maintain product stability.

The product is applied as an ophthalmic solution. The prescriber will instruct the patient to instill the recommended number of drops into the affected eye(s) at the specified intervals, typically avoiding contact lens wear immediately after administration.

Serious but rare risks include severe allergic reactions such as angioedema, corneal ulceration, vision loss and anaphylaxis. Patients should seek immediate medical attention if they experience sudden eye pain, swelling, or visual changes after using the drops.

Individuals with a known hypersensitivity to sodium cromoglicate or any component of the formulation should avoid using Lecrolyn Sine. Additionally, patients with active corneal infections or severe ocular surface disease should be evaluated by an eye specialist before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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