Product image of Lecrolyn Sine (Sodium Cromoglicate) supplied by GNH India

Lecrolyn Sine

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Lecrolyn Sine (Sodium Cromoglicate)

Sodium cromoglicate, the active ingredient in Lecrolyn Sine, is a mast cell stabilizer presented as an ophthalmic solution for ocular use. It treats allergic conjunctivitis and mast cell‑mediated ocular allergy in patients requiring topical antiallergic therapy.

GNH India supplies Lecrolyn Sine as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

  • Lecrolyn Sine is a mast cell stabilizer used to manage ocular allergic conditions.
  • Allergic conjunctivitis: reduces itching, redness, and tearing caused by allergen exposure.
  • Mast cell‑mediated ocular allergy: prevents mast cell degranulation and histamine release in the eye.
  • Seasonal allergic eye disease: alleviates symptoms during pollen or other seasonal allergen periods.

How It Works

  • Sodium cromoglicate stabilises ocular mast cells by inhibiting calcium influx, which prevents the release of histamine, leukotrienes, prostaglandins and other inflammatory mediators. This action reduces vascular permeability and inflammatory cell recruitment, thereby decreasing ocular allergic inflammation without directly blocking histamine receptors.

Side Effects

Adverse reactions are generally mild and related to local ocular tolerance.

Common Side Effects

  • Transient burning or stinging sensation after instillation.
  • Mild eye irritation or foreign‑body feeling.
  • Temporary blurred vision.
  • Slight conjunctival redness.
  • Mild tearing.
  • Discomfort that resolves within minutes.

Serious or Rare Side Effects

  • Severe ocular inflammation or keratitis.
  • Allergic reaction with swelling or rash.
  • Corneal ulceration.
  • Vision loss.
  • Anaphylactic response (extremely rare).

Precautions & Warnings

  • Use Lecrolyn Sine only under ophthalmic supervision and observe the following precautions.
  • Do not use if hypersensitivity: discontinue immediately if allergic reaction occurs.
  • Avoid contact lens wear: remove lenses before and for at least 15 minutes after administration.
  • Monitor symptom progression: seek medical advice if condition worsens.
  • Use only as prescribed: do not exceed recommended frequency.
  • Discontinue if severe irritation persists.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lecrolyn Sine may interact with other ocular medications; consider the following.

Major Interactions (Avoid)

  • Concurrent use with other mast cell stabilisers may increase local irritation.
  • Combination with topical corticosteroids may mask signs of infection.

Moderate Interactions (Monitor Closely)

  • Co‑administration with antihistamine eye drops may increase ocular dryness.
  • Use with preservative‑containing contact lens solutions may heighten irritation.
  • Systemic antihistamines may reduce overall antiallergic effect.

Frequently Asked Questions

Lecrolyn Sine is an ophthalmic preparation containing sodium cromoglicate. It is used to treat allergic conjunctivitis and other mast cell‑mediated ocular allergies by stabilising mast cells and reducing inflammatory symptoms such as itching, redness, and tearing.

Sodium cromoglicate acts as a mast cell stabiliser. It inhibits calcium influx into mast cells, preventing the release of histamine, leukotrienes, prostaglandins and other mediators that cause ocular inflammation, thereby decreasing allergic eye symptoms.

The dosing regimen for Lecrolyn Sine is determined by the prescribing ophthalmologist based on the severity of the allergic condition and patient response. Patients should follow the specific instructions provided by their eye care professional.

Safety data for sodium cromoglicate in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk, and this decision must be made by the treating physician in consultation with the patient.

To order Lecrolyn Sine, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lecrolyn Sine (sodium cromoglicate) differs from antihistamine eye drops because it stabilises mast cells rather than blocking histamine receptors. This mechanism can provide broader control of allergic inflammation and may be used when antihistamines alone are insufficient.

Lecrolyn Sine should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from light and moisture, and avoid freezing the product.

Lecrolyn Sine is applied as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, instil the prescribed number of drops, and close the eyes gently for a few seconds. Contact lenses should be removed before administration.

Serious, though rare, risks include severe ocular inflammation, corneal ulceration, vision loss, and anaphylactic reactions. Patients should seek immediate medical attention if they experience sudden worsening of vision, intense pain, or signs of a systemic allergic response.

Individuals with known hypersensitivity to sodium cromoglicate or any component of the formulation should avoid using Lecrolyn Sine. It is also contraindicated in patients with active ocular infections unless directed by an ophthalmologist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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