Product image of Lecrolyn (Sodium Cromoglicate) supplied by GNH India

Lecrolyn

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Lecrolyn (Sodium Cromoglicate)

Sodium Cromoglicate, the active ingredient in Lecrolyn, is a mast cell stabilizer presented as an ophthalmic solution for ocular use. It helps control allergic conjunctivitis and other mast cell‑mediated eye inflammation in patients prone to ocular allergies. The drug is formulated for topical administration directly onto the eye surface, providing localized effect with minimal systemic absorption.

GNH India supplies Lecrolyn as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable logistics for global distribution.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Lecrolyn, a mast cell stabilizer, is used to manage ocular allergic conditions by preventing mediator release.

  • Allergic conjunctivitis: reduces ocular itching, redness, and swelling caused by allergen exposure.
  • Ocular allergy (seasonal or perennial): stabilizes mast cells to prevent recurrent eye irritation and watery discharge.
  • Mast cell‑mediated ocular inflammation: limits inflammatory response in conditions such as vernal keratoconjunctivitis.
  • Contact lens‑associated allergic reaction: helps maintain comfort and reduces inflammatory signs in lens wearers.

How It Works

  • Sodium Cromoglicate acts by stabilizing mast cell membranes in conjunctival and corneal tissues, preventing degranulation. This inhibition blocks the release of histamine, leukotrienes, prostaglandins and cytokines that drive allergic inflammation. The topical ocular application allows the drug to act directly at the site of allergen exposure, reducing vascular permeability and cellular infiltration without significant systemic absorption.

Side Effects

Topical ocular use of Lecrolyn may be associated with local and, rarely, systemic adverse reactions.

Common Side Effects

  • Eye irritation or burning sensation: transient discomfort after instillation.
  • Blurred vision: temporary visual disturbance that resolves quickly.
  • Redness of the conjunctiva: mild injection of the eye.
  • Watery discharge: increased tearing.

Serious or Rare Side Effects

  • Allergic contact dermatitis: hypersensitivity reaction around the eye.
  • Severe ocular inflammation: persistent redness, pain, or vision changes requiring medical attention.

Precautions & Warnings

When prescribing or dispensing Lecrolyn, consider the following precautions to ensure safe and effective use.

  • Indication verification: confirm diagnosis of allergic ocular condition before use.
  • Contact lens use: advise patients to remove lenses before instillation and wait before reinserting.
  • Concomitant eye medications: schedule Lecrolyn at least five minutes apart from other drops to avoid dilution.
  • Pediatric use: exercise caution and follow pediatric dosing guidelines if prescribed for children.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk, as safety data are limited.
  • Store at ambient temperature: keep the product below 25 °C in the original container, protected from light and moisture.

Avoid Interactions

Lecrolyn may interact with other ophthalmic agents or systemic drugs that affect mast cell function.

Major Interactions (Avoid)

  • Antihistamine eye drops containing preservatives: may increase ocular irritation when combined.
  • Systemic mast cell stabilizers: concurrent use offers no added benefit and may complicate assessment of efficacy.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: monitor for additive effects on ocular surface.
  • Topical corticosteroids: assess for overlapping anti‑inflammatory actions.
  • Contact lens solutions containing preservatives: observe for increased sensitivity.

Frequently Asked Questions

Lecrolyn is an ophthalmic formulation of sodium cromoglicate indicated for the treatment of allergic conjunctivitis, seasonal or perennial ocular allergy, and other mast cell‑mediated inflammatory conditions of the eye. It helps relieve symptoms such as itching, redness, swelling and watery discharge by stabilizing ocular mast cells.

Sodium cromoglicate stabilizes the membranes of mast cells located in the conjunctiva and cornea. By preventing mast‑cell degranulation, it blocks the release of histamine, leukotrienes, prostaglandins and cytokines that trigger allergic inflammation, thereby reducing ocular redness, itching and swelling without significant systemic exposure.

The dosing regimen for Lecrolyn is determined by the prescribing clinician based on the severity of the allergic condition and patient factors. Typically, one or two drops are instilled into the affected eye(s) as directed, but the exact frequency and duration should follow the prescriber’s instructions.

Safety data for sodium cromoglicate eye drops in pregnancy and lactation are limited. Use is generally reserved for situations where the potential therapeutic benefit outweighs any possible risk to the fetus or infant. The prescriber should evaluate the individual case and discuss any concerns with the patient.

To request Lecrolyn, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lecrolyn (sodium cromoglicate) is a mast‑cell stabilizer, whereas many other ocular antiallergics, such as antihistamine or mast‑cell‑blocking eye drops, act by directly antagonising histamine receptors. Lecrolyn’s mechanism prevents the release of multiple inflammatory mediators, offering a broader anti‑inflammatory effect, but it may act more slowly than fast‑acting antihistamines.

Lecrolyn should be stored at ambient temperature, preferably below 25 °C, in its original container. Keep the bottle tightly closed, protect it from direct light and moisture, and avoid freezing. Do not use the product if the solution appears discoloured or if the container is damaged.

Lecrolyn is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. The eye should be closed gently for a few seconds to allow absorption, and contact lenses should be removed before instillation and re‑inserted after a short interval.

Serious but rare risks include allergic contact dermatitis around the eye and severe ocular inflammation that may present as persistent redness, pain, or visual changes. If any of these symptoms occur, the patient should discontinue use and seek immediate medical evaluation.

Lecrolyn should be avoided in individuals with known hypersensitivity to sodium cromoglicate or any excipients in the formulation. Patients with active severe ocular infection or uncontrolled ocular surface disease should not use the product until the condition is resolved, and it should be used with caution in children unless specifically prescribed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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