Product image of Lecrolyn (Sodium Cromoglicate) supplied by GNH India

Lecrolyn

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Lecrolyn (Sodium Cromoglicate)

Sodium cromoglicate, the active ingredient in Lecrolyn, is a mast cell stabilizer presented as an ophthalmic solution for ocular use. It helps control allergic conjunctivitis and vernal keratoconjunctivitis by reducing histamine release in the eyes of affected patients.

GNH India supplies Lecrolyn as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics worldwide under strict quality standards and regulatory compliance. The company manages export logistics, documentation, and post‑market support to ensure reliable availability across diverse healthcare settings.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Lecrolyn, a mast cell stabilizer, is used to manage ocular allergic conditions.

  • Allergic conjunctivitis: reduces itching, redness and tearing caused by ocular allergy.
  • Vernal keratoconjunctivitis: decreases inflammation and helps prevent corneal damage in chronic seasonal allergy.
  • Seasonal allergic conjunctivitis: alleviates eye symptoms during pollen season.

How It Works

  • Sodium cromoglicate stabilizes mast cells by inhibiting calcium‑dependent degranulation, which prevents the release of histamine, leukotrienes and other inflammatory mediators from ocular mast cells. By limiting these mediators, the drug reduces vascular permeability, edema and the sensory nerve activation that cause allergic eye symptoms. The effect is localized to the ocular surface, providing targeted anti‑allergic activity without systemic absorption. This mechanism underlies its use in both acute and chronic allergic eye disease.

Side Effects

Sodium cromoglicate ophthalmic solution may cause local ocular reactions, most of which are mild and transient.

Common Side Effects

  • Burning sensation: transient feeling of heat after instillation.
  • Stinging: brief sharp discomfort in the eye.
  • Redness: mild conjunctival hyperemia.
  • Blurred vision: temporary visual disturbance that resolves quickly.

Serious or Rare Side Effects

  • Severe allergic reaction: signs of anaphylaxis such as swelling, difficulty breathing.
  • Corneal ulcer: rare but serious corneal injury requiring immediate medical attention.

Precautions & Warnings

When using Lecrolyn, follow these safety measures.

  • Avoid contact with contaminated hands: use sterile technique when instilling.
  • Do not use if solution is discolored or particulate: discard any compromised product.
  • Consult eye care professional if symptoms persist beyond 7 days: seek evaluation for possible alternative therapy.
  • Pregnancy and lactation: safety not established; use only if clearly needed after risk assessment.
  • Concurrent ocular medications: separate instillation by at least 5 minutes to avoid interaction.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Sodium cromoglicate may interact with other ocular products.

Major Interactions (Avoid)

  • Contact lens solutions containing preservatives: may cause irritation when used together.
  • Topical ocular steroids: combined use can increase risk of infection.

Moderate Interactions (Monitor Closely)

  • Systemic antihistamines: may mask ocular symptoms, requiring monitoring.
  • Other mast cell stabilizers: additive effect could increase local irritation.
  • Non‑steroidal anti‑inflammatory eye drops: monitor for increased discomfort.

Frequently Asked Questions

Lecrolyn is an ophthalmic solution containing sodium cromoglicate. It is indicated for the treatment of allergic conjunctivitis and vernal keratoconjunctivitis, helping to relieve eye itching, redness, tearing and swelling caused by allergic reactions.

Sodium cromoglicate stabilizes mast cells in the ocular surface, preventing calcium‑dependent degranulation. This blocks the release of histamine, leukotrienes and other inflammatory mediators, thereby reducing vascular permeability, edema and sensory nerve activation that produce allergic eye symptoms.

The dosing regimen for Lecrolyn is determined by the prescribing eye‑care professional. Typical use involves instilling the recommended number of drops per eye at the frequency indicated on the prescription, which may vary according to severity and patient response.

Safety of sodium cromoglicate ophthalmic solution in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies any possible risk to the mother or infant, and after consultation with a healthcare provider.

To order Lecrolyn, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lecrolyn (sodium cromoglicate) is a mast cell stabilizer, whereas many alternatives such as olopatadine or ketotifen are antihistamines. Mast cell stabilizers act upstream by preventing mediator release, offering a prophylactic effect, while antihistamines block histamine receptors and provide rapid symptom relief. Choice depends on clinical need and physician preference.

Lecrolyn should be stored at room temperature, preferably below 25 °C, in its original container. Protect the solution from direct light and moisture. Do not freeze. Once opened, follow the manufacturer’s recommended period‑after‑opening (PAO) and discard any remaining product after that time.

Lecrolyn is administered as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. Avoid touching the dropper tip to the eye or any surface to maintain sterility.

Although rare, serious adverse reactions can include severe allergic responses such as anaphylaxis, and corneal ulceration. Patients should seek immediate medical attention if they experience swelling of the face or throat, difficulty breathing, or persistent eye pain and visual changes.

Lecrolyn should not be used by individuals with known hypersensitivity to sodium cromoglicate or any component of the formulation. It is also contraindicated in eyes that are infected, inflamed for reasons other than allergy, or when the solution appears discolored or contains particles.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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