Product image of Lecrolyn (Sodium Cromoglicate) supplied by GNH India

Lecrolyn

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Lecrolyn (Sodium Cromoglicate)

Sodium cromoglicate, the active ingredient in Lecrolyn, is a mast cell stabilizer presented as a solution for ocular use. It helps relieve allergic eye symptoms in patients with ocular allergy.

GNH India supplies Lecrolyn as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

  • Sodium cromoglicate is used to manage allergic ocular conditions by stabilizing mast cells.
  • Allergic conjunctivitis: reduces itching, redness, and tearing associated with seasonal or perennial eye allergies.
  • Vernal keratoconjunctivitis: helps control chronic inflammation in patients with this seasonal allergic disease.
  • Atopic keratoconjunctivitis: may be used as an adjunct to lessen ocular surface inflammation in atopic individuals.

How It Works

  • Sodium cromoglicate binds to mast cell membranes and prevents calcium influx, thereby inhibiting degranulation. This blocks the release of histamine, leukotrienes, and other inflammatory mediators that cause ocular itching, redness, and swelling. The drug acts locally on the conjunctival and corneal tissues, providing anti‑allergic effects without significant systemic absorption.

Side Effects

Sodium cromoglicate is generally well tolerated, but ocular administration can produce local reactions.

Common Side Effects

  • Transient burning or stinging sensation upon instillation.
  • Mild eye irritation or foreign‑body feeling.
  • Temporary blurred vision that resolves quickly.
  • Increased tearing or watery discharge.
  • Mild headache related to eye strain.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema of the eyelid).
  • Persistent eye pain or worsening redness.
  • Corneal ulceration or epithelial defect.
  • Vision loss or sudden visual disturbance.
  • Anaphylaxis (extremely rare).

Precautions & Warnings

  • When using Lecrolyn, consider the following safety measures.
  • Avoid use in patients with known hypersensitivity to sodium cromoglicate or any formulation excipients.
  • Do not wear contact lenses during treatment; remove them before each dose and wait at least 15 minutes before reinserting.
  • Monitor for worsening ocular symptoms; discontinue and seek medical advice if irritation persists.
  • Inform the prescriber of any concurrent ocular infections or recent eye surgery.
  • Store below 25°C: keep in the original container, protect from moisture and light, and do not freeze.

Avoid Interactions

Sodium cromoglicate has limited systemic absorption, but ocular co‑medications may influence its safety profile.

Major Interactions (Avoid)

  • None identified: no major drug‑drug interactions have been reported for ocular sodium cromoglicate.

Moderate Interactions (Monitor Closely)

  • Concurrent use with other mast cell stabilizers may increase local irritation.
  • Co‑administration with topical corticosteroids could mask signs of infection.
  • Use with certain contact lens cleaning solutions may affect drug stability.

Frequently Asked Questions

Lecrolyn contains sodium cromoglicate, a mast cell stabilizer indicated for the treatment of allergic eye conditions such as allergic conjunctivitis, vernal keratoconjunctivitis, and atopic keratoconjunctivitis. It works by reducing the release of histamine and other inflammatory mediators that cause itching, redness, and tearing.

Sodium cromoglicate stabilizes mast cells on the ocular surface, preventing calcium‑dependent degranulation. By blocking the release of histamine, leukotrienes, and other inflammatory substances, it reduces the allergic response that leads to ocular irritation, swelling, and discharge.

The dosing regimen for Lecrolyn is determined by the prescribing eye‑care professional based on the severity of the allergic condition, patient age, and response to therapy. Patients should follow the specific instructions provided by their ophthalmologist or optometrist.

Safety data for sodium cromoglicate in pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against any unknown risks before prescribing. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Lecrolyn with their doctor.

To request Lecrolyn, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lecrolyn (sodium cromoglicate) differs from antihistamine eye drops by stabilizing mast cells rather than blocking histamine receptors. This mechanism can provide longer‑lasting control of allergic inflammation and is often used when antihistamines alone are insufficient. It is also non‑steroidal, reducing the risk of steroid‑related side effects.

Lecrolyn should be stored below 25 °C, protected from moisture and direct light, and kept in its original container. Do not freeze the solution. If the product appears discolored or contains particles, discard it and obtain a new supply.

Lecrolyn is applied as an ophthalmic solution. The patient instills the prescribed number of drops into the affected eye(s) as directed by the eye‑care professional, typically avoiding contact lens wear during and shortly after administration.

While rare, serious adverse events can include severe allergic reactions such as angioedema of the eyelid, corneal ulceration, sudden vision loss, or anaphylaxis. Patients should seek immediate medical attention if they experience intense pain, rapid vision changes, or signs of a severe eye infection.

Lecrolyn is contraindicated in individuals with a known hypersensitivity to sodium cromoglicate or any component of the formulation. Patients with active ocular infections, recent eye surgery, or those who cannot tolerate the local irritation should discuss alternative therapies with their ophthalmologist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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