Product image of Lecrolyn (Sodium Cromoglicate) supplied by GNH India

Lecrolyn

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Lecrolyn (Sodium Cromoglicate)

Sodium Cromoglicate, the active ingredient in Lecrolyn, is a mast cell stabilizer presented as a topical ophthalmic solution for ocular use. It is indicated for the treatment of allergic conjunctivitis and other ocular allergic conditions, where it works by inhibiting mast cell degranulation and preventing the release of histamine and other inflammatory mediators that cause eye irritation, redness, and itching.

GNH India supplies Lecrolyn as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for ophthalmic antiallergic agents.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Lecrolyn, a mast cell stabilizer, is used to manage ocular allergic disorders by preventing mast cell mediator release.

  • Allergic conjunctivitis: reduces eye redness, itching and tearing associated with seasonal and perennial allergens.
  • Vernal keratoconjunctivitis: helps control inflammation and itching in this chronic allergic eye disease.
  • Seasonal ocular allergy: alleviates symptoms of eye irritation during pollen seasons.

How It Works

  • Sodium cromoglicate stabilizes mast cells by binding to calcium channels on the cell membrane, which inhibits calcium influx required for degranulation. This prevents the release of histamine, leukotrienes, prostaglandins and other inflammatory mediators from ocular mast cells, thereby reducing vascular permeability, edema and the sensory nerve activation that produce itching, redness and swelling in allergic eye conditions.

Side Effects

Adverse ocular reactions to Lecrolyn are generally mild and transient, but rare serious events have been reported.

Common Side Effects

  • Burning sensation: mild stinging upon instillation.
  • Eye irritation: temporary gritty feeling.
  • Blurred vision: transient visual haziness after dosing.

Serious or Rare Side Effects

  • Allergic contact dermatitis: localized swelling and rash.
  • Corneal ulceration: persistent pain and visual disturbance.
  • Anaphylaxis: systemic allergic reaction, though extremely uncommon.

Precautions & Warnings

Before using Lecrolyn, consider the following precautions to ensure safe and effective therapy.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Contact lens wearers: remove lenses prior to instillation and wait before reinserting.
  • Ocular infection: avoid use if active eye infection is present.
  • Hypersensitivity: discontinue if signs of allergic reaction occur.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lecrolyn may interact with other ophthalmic agents; awareness of these interactions helps optimize treatment.

Major Interactions (Avoid)

  • Concurrent use of ocular anesthetics: may increase ocular irritation.
  • Combination with other mast cell stabilizers: provides no added benefit and may increase exposure.

Moderate Interactions (Monitor Closely)

  • Co‑administration with antihistamine eye drops: may reduce efficacy of either product.
  • Use with topical corticosteroids: monitor for additive anti‑inflammatory effects.
  • Preservative‑containing contact lens solutions: may heighten irritation.

Frequently Asked Questions

Lecrolyn is an ophthalmic solution containing sodium cromoglicate that is used to treat allergic conjunctivitis and other ocular allergic conditions. It works by stabilizing mast cells in the eye, thereby reducing symptoms such as redness, itching, and tearing associated with allergic reactions.

Sodium cromoglicate acts as a mast cell stabilizer. It binds to calcium channels on mast cells, limiting calcium influx and preventing degranulation. This blocks the release of histamine and other inflammatory mediators that cause the characteristic signs of ocular allergy.

The dosing regimen for Lecrolyn is determined by the prescribing clinician. Typically, the prescriber will advise the number of drops per eye and the frequency of administration based on the severity of the allergic condition and the patient’s response.

Safety data for sodium cromoglicate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lecrolyn.

To order Lecrolyn, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lecrolyn’s active ingredient, sodium cromoglicate, is a mast cell stabilizer, whereas many other ocular antiallergics are antihistamines or combination products. Mast cell stabilizers act upstream by preventing mediator release, offering a complementary mechanism that can be used alone or with antihistamine drops for broader symptom control.

Lecrolyn should be stored at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed when not in use and retain it in its original packaging to protect the formulation from contamination.

Lecrolyn is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to form a pocket, and instill the prescribed number of drops. The eye should be closed gently for a few seconds to allow the solution to spread.

While most reactions are mild, serious adverse events can include allergic contact dermatitis, corneal ulceration, and, in extremely rare cases, anaphylaxis. Any sudden increase in pain, vision loss, or systemic allergic symptoms should prompt immediate medical evaluation.

Lecrolyn should be avoided in individuals with a known hypersensitivity to sodium cromoglicate or any excipients in the formulation. It is also contraindicated in eyes with active infection until the infection has been treated, and patients should consult a clinician before use if they have severe ocular surface disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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