Product image of Lecrosine (Sodium Cromoglicate) supplied by GNH India

Lecrosine

Active Ingredient:
Sodium Cromoglicate
Origin:
EU

Lecrosine (Sodium Cromoglicate)

Sodium cromoglicate, the active ingredient in Lecrosine, is a mast cell stabilizer presented as an ophthalmic solution for ocular use. It helps control allergic inflammation of the eye in patients with seasonal or vernal allergic conjunctivitis.
GNH India supplies Lecrosine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Lecrosine, a mast cell stabilizer, is used to manage ocular allergic conditions by preventing mast‑cell degranulation.

  • Allergic conjunctivitis: reduces redness, itching and watery discharge caused by seasonal allergens.
  • Vernal keratoconjunctivitis: helps control chronic inflammation and photophobia in patients with this severe form of allergic eye disease.
  • Seasonal allergic conjunctivitis: provides prophylactic relief during high pollen periods, decreasing symptom severity.

How It Works

  • Sodium cromoglicate stabilises the membranes of mast cells in the conjunctival and corneal tissues, inhibiting calcium‑dependent degranulation. By preventing the release of histamine, prostaglandins and other inflammatory mediators, it reduces vascular permeability and the subsequent ocular itching, redness and swelling associated with allergic reactions.

Side Effects

Adverse reactions to ocular sodium cromoglicate are generally mild and related to the formulation.

Common Side Effects

  • Transient burning or stinging sensation upon instillation.
  • Mild ocular irritation or foreign‑body sensation.
  • Temporary blurred vision that resolves quickly.
  • Conjunctival hyperemia (redness).
  • Tearing or increased lacrimation.

Serious or Rare Side Effects

  • Persistent ocular irritation lasting more than 24 hours.
  • Development of corneal epithelial defects.
  • Severe allergic reaction to preservative components.
  • Vision loss unrelated to underlying disease.
  • Secondary ocular infection.

Precautions & Warnings

When using Lecrosine, consider the following safety measures.

  • Avoid contact with the tip of the bottle to prevent contamination.
  • Do not use if the solution appears discoloured or contains particles.
  • Discontinue if severe irritation or allergic reaction occurs and consult a healthcare professional.
  • Use only as prescribed; do not exceed the recommended frequency.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lecrosine may interact with other ocular medications or systemic agents that affect mast‑cell function.

Major Interactions (Avoid)

  • Concurrent use of other mast‑cell stabilisers may increase local irritation.
  • Co‑administration with topical antihistamines containing preservatives that can cause additive ocular surface toxicity.

Moderate Interactions (Monitor Closely)

  • Systemic corticosteroids may alter the inflammatory response, requiring monitoring of symptom control.
  • Use with contact lenses may reduce drug efficacy; advise removal before instillation.
  • Concomitant use of ocular antibiotics may mask signs of infection; monitor for infection signs.

Frequently Asked Questions

Lecrosine contains sodium cromoglicate, a mast cell stabiliser formulated for ocular use. It is prescribed to manage allergic eye conditions such as allergic conjunctivitis and vernal keratoconjunctivitis by preventing the release of inflammatory mediators that cause redness, itching and tearing.

Sodium cromoglicate stabilises mast‑cell membranes in the conjunctiva and cornea, blocking calcium‑dependent degranulation. This inhibition stops the release of histamine, prostaglandins and other mediators, thereby reducing vascular leakage, itching and swelling that characterize allergic eye reactions.

The dosage of Lecrosine is determined by the prescribing clinician based on the severity of the allergic condition, patient age and response to therapy. The prescriber will specify the number of drops, frequency and duration appropriate for each individual case.

Safety data for sodium cromoglicate in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any unknown risks before prescribing Lecrosine to pregnant or nursing individuals. Consultation with a specialist is recommended.

To request Lecrosine, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and import documentation.

Lecrosine (sodium cromoglicate) differs from antihistamine eye drops by stabilising mast cells rather than blocking histamine receptors. This mechanism offers prophylactic control of allergic inflammation, whereas antihistamines provide rapid symptom relief. Choice depends on clinical goals, patient tolerance and physician preference.

Lecrosine should be stored at temperatures below 25 °C, in its original container, protected from moisture and direct sunlight. Do not freeze the product. Ensure the cap is tightly closed to maintain sterility and potency.

Lecrosine is applied as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, and instil the prescribed number of drops into the conjunctival sac. Avoid touching the bottle tip to the eye or any surface.

Serious risks, though rare, include persistent ocular irritation, development of corneal epithelial defects, severe allergic reactions to preservatives, and secondary eye infections. If any of these occur, discontinue use immediately and seek medical attention.

Lecrosine should be avoided in patients with known hypersensitivity to sodium cromoglicate or any excipients in the formulation. It is also contraindicated if the solution is discoloured, contains particles, or if the patient has active ocular infection that requires alternative therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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