Product image of Lectil (Betahistine Dihydrochloride) supplied by GNH India

Lectil

Active Ingredient:
Betahistine Dihydrochloride
Origin:
EU

Lectil (Betahistine Dihydrochloride)

Betahistine Dihydrochloride, the active ingredient in Lectil, is a histamine H1 receptor agonist / H3 receptor antagonist presented as an oral formulation for oral use. It is used to manage vestibular disorders such as Meniere's disease and vertigo in adults and is prescribed by physicians to improve inner ear microcirculation and reduce associated symptoms.

GNH India supplies Lectil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance and reliable global distribution networks.

Manufacturer / TM Owner

Bouchara Recordati

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Indications & Clinical Uses

Lectil (betahistine dihydrochloride) is employed in the management of vestibular disorders affecting inner‑ear function.

  • Meniere's disease: reduces frequency and severity of attacks by improving inner ear microcirculation.
  • Vertigo: alleviates spinning sensations through histamine‑mediated vascular effects.
  • Vestibular disorders: enhances balance function by increasing histamine release in the vestibular nuclei.

How It Works

  • Betahistine dihydrochloride acts as a partial agonist at histamine H1 receptors while antagonising H3 receptors. H1 activation causes vasodilation of the inner‑ear vessels, improving microcirculation. H3 blockade prevents inhibitory feedback on histamine release, thereby increasing endogenous histamine levels in the vestibular nuclei. The combined effect enhances blood flow and stabilises vestibular signalling, helping to reduce episodic symptoms of disorders such as Meniere’s disease.

Side Effects

Betahistine may be associated with several adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.
  • Gastric irritation: mild abdominal discomfort.

Serious or Rare Side Effects

  • Allergic reaction: urticaria, swelling, or anaphylaxis.
  • Arrhythmia: irregular heart rhythm.
  • Severe hypotension: marked blood pressure drop.

Precautions & Warnings

When prescribing betahistine, clinicians should consider several precautionary measures to ensure patient safety.

  • Renal impairment: adjust use in patients with severe kidney dysfunction.
  • Cardiovascular disease: monitor for arrhythmias or blood pressure changes.
  • Pregnancy: evaluate risk‑benefit as safety data are limited.
  • Concomitant antihistamines: avoid concurrent use with strong H1 antagonists that may reduce efficacy.
  • Elderly patients: start at lower dose and monitor for dizziness.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Betahistine can interact with other medicines, requiring attention to potential additive effects.

Major Interactions (Avoid)

  • Strong H1 antihistamines: may counteract betahistine’s action.
  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive episodes.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may increase vestibular side effects.
  • Diuretics: may alter inner‑ear fluid balance.
  • Anticoagulants: monitor for increased bleeding risk.

Frequently Asked Questions

Lectil contains betahistine dihydrochloride and is used to treat vestibular disorders, primarily Meniere's disease and vertigo. By improving inner‑ear blood flow, it helps reduce the frequency and intensity of balance‑related episodes in adult patients.

Betahistine acts as a partial agonist at histamine H1 receptors, causing vasodilation in the inner ear, and as an antagonist at H3 receptors, which increases the release of endogenous histamine. This dual action enhances microcirculation and stabilises vestibular signalling.

The specific dose of Lectil is determined by the prescribing clinician based on the individual’s condition, age, renal function and response to therapy. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for betahistine during pregnancy and lactation are limited. Clinicians should weigh potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing women.

To request Lectil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other vestibular agents such as diuretics or corticosteroids, betahistine’s mechanism focuses on histamine‑mediated vasodilation rather than fluid reduction. It is generally well tolerated, but clinical choice depends on individual patient profile and physician judgment.

Lectil should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Lectil is taken orally, usually as a tablet, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events are rare but may include allergic reactions such as urticaria or anaphylaxis, cardiac arrhythmias, and severe hypotension. Patients should seek immediate medical attention if they experience signs of an allergic response or sudden cardiovascular symptoms.

Lectil is contraindicated in patients with known hypersensitivity to betahistine or any excipients, and it should be used with caution in individuals with severe renal impairment, uncontrolled cardiovascular disease, or those taking strong H1 antagonists that could negate its effect.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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