Product image of Lectil (Betahistine Dihydrochloride) supplied by GNH India

Lectil

Active Ingredient:
Betahistine Dihydrochloride
Origin:
EU

Lectil (Betahistine Dihydrochloride)

Betahistine Dihydrochloride, the active ingredient in Lectil, is a histamine analog that acts as an H1 receptor agonist and H3 antagonist, presented as an oral tablet for oral use. It is employed to alleviate vertigo, Meniere’s disease and other balance disorders in adult patients.

GNH India supplies Lectil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across all markets. The company maintains robust cold‑chain logistics where required and provides full documentation for import and customs clearance.

Manufacturer / TM Owner

Bouchara Recordati

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Indications & Clinical Uses

  • Lectil (betahistine) works on the vestibular apparatus by enhancing histamine turnover and inner‑ear blood flow, and it is formally indicated for the following clinically recognised conditions.
  • Vertigo: Reduces the frequency and intensity of spinning sensations in patients with vestibular dysfunction.
  • Meniere's disease: Helps control episodic vertigo and associated hearing fluctuations.
  • Balance disorders: Improves postural stability in individuals with chronic disequilibrium.

How It Works

  • Betahistine Dihydrochloride acts as a partial agonist at histamine H1 receptors while antagonising H3 receptors. The H1 stimulation causes vasodilation of the inner‑ear vessels, increasing microcirculation, whereas H3 blockade raises endogenous histamine release, further supporting vascular flow and reducing endolymphatic pressure. This combined action improves vestibular function and alleviates vertiginous episodes. The enhanced blood supply helps normalize the ionic composition of the endolymph, which contributes to the reduction of abnormal vestibular signalling.

Side Effects

Betahistine is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Headache: mild to moderate headache reported.
  • Nausea: occasional gastrointestinal upset.
  • Indigestion: dyspeptic symptoms such as heartburn.
  • Transient flushing: brief skin redness.

Serious or Rare Side Effects

  • Allergic reaction: rash, pruritus, or angioedema requiring medical attention.
  • Severe hypotension: marked drop in blood pressure, especially when combined with other vasodilators.
  • Cardiac arrhythmia: rare reports of irregular heartbeat.

Precautions & Warnings

  • When prescribing betahistine, clinicians should consider the following precautions to ensure safe use.
  • Renal impairment: adjust use in patients with severe kidney dysfunction.
  • Cardiovascular disease: monitor blood pressure in individuals with known hypotension.
  • Concomitant antihistamines: avoid combining with strong H1 antagonists that may counteract effect.
  • Pregnancy and lactation: use only if potential benefit outweighs risk, as data are limited.
  • Elderly patients: start at lower dose and monitor for adverse effects.
  • Store at ambient temperature: keep tablets in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Betahistine may interact with other medicines; the following interactions are noteworthy.

Major Interactions (Avoid)

  • Strong vasodilators (e.g., nitroglycerin): may cause additive hypotensive effect.
  • Monoamine oxidase inhibitors (MAOIs): risk of excessive histamine activity.
  • Antihistamines (first‑generation H1 blockers): may diminish therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: monitor blood pressure for additive lowering.
  • CYP450 substrates: betahistine is minimally metabolized, but monitor for unexpected changes.
  • Diuretics: watch for electrolyte disturbances.

Frequently Asked Questions

Lectil contains betahistine, which is prescribed to manage vertigo, control episodes of Meniere’s disease, and improve overall balance in patients with vestibular dysfunction. By enhancing inner‑ear blood flow, it helps reduce the frequency and severity of spinning sensations and related equilibrium problems.

Betahistine acts as a partial agonist at histamine H1 receptors and an antagonist at H3 receptors. H1 stimulation dilates blood vessels in the inner ear, increasing microcirculation, while H3 blockade raises endogenous histamine release, further supporting vascular flow and reducing endolymphatic pressure, which together improve vestibular function.

The appropriate dose of Lectil is determined by the prescribing clinician based on the individual’s medical condition, severity of symptoms, age, and renal function. Healthcare professionals tailor the regimen to achieve optimal symptom control while minimizing potential adverse effects.

Safety data for betahistine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To request Lectil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

The primary alternative for vertigo management includes vestibular suppressants such as antihistamines (e.g., meclizine) or anticholinergics. Unlike those agents, betahistine improves inner‑ear microcirculation rather than merely suppressing symptoms, which can result in better long‑term balance control and fewer sedative side effects.

Lectil tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Lectil is taken orally with a glass of water. It can be taken with or without food, according to the prescriber’s instructions. Swallow the tablet whole; do not crush or chew unless specifically directed by a healthcare professional.

Serious adverse reactions, although rare, include allergic responses such as rash, itching, or angioedema, severe hypotension, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience any signs of an allergic reaction, a sudden drop in blood pressure, or irregular heartbeats.

Lectil is contraindicated in patients with known hypersensitivity to betahistine or any of its excipients. Caution is advised for individuals with severe renal impairment, uncontrolled hypotension, or those taking strong vasodilators, as the combination may increase the risk of low blood pressure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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