Product image of Ledertrexato (Methotrexate) supplied by GNH India

Ledertrexato

Active Ingredient:
Methotrexate
Origin:
EU

Ledertrexato (Methotrexate)

Methotrexate, the active ingredient in Ledertrexato, is an antimetabolite presented as an oral tablet for oral use. It interferes with folate metabolism and is indicated for the management of autoimmune diseases such as rheumatoid arthritis and psoriasis, as well as for several hematologic and solid‑tumor cancers in both adult and pediatric populations.

GNH India supplies Ledertrexato as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, transplant units and pharmacies worldwide, ensuring quality and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

Laboratórios Pfizer Lda.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Methotrexate is used in several autoimmune and oncologic disease pathways, providing disease control and symptom relief.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: decreases skin lesion severity and plaque formation.
  • Acute lymphoblastic leukemia: induces remission by targeting rapidly dividing lymphoblasts.
  • Non‑Hodgkin lymphoma: impairs tumor cell proliferation and promotes apoptosis.
  • Gestational trophoblastic disease: eradicates trophoblastic tissue and prevents disease recurrence.

How It Works

  • Methotrexate inhibits the enzyme dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the cellular pool of tetrahydrofolate, a cofactor required for synthesis of purine nucleotides and thymidylate, thereby suppressing DNA, RNA and protein synthesis in rapidly dividing cells. The resulting antiproliferative effect underlies its efficacy in both malignant and inflammatory conditions.

Side Effects

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea or vomiting: gastrointestinal discomfort occurring early in therapy.
  • Stomatitis: inflammation or ulceration of the oral mucosa.
  • Fatigue: persistent tiredness not relieved by rest.
  • Elevated liver enzymes: mild transaminase increase detectable on blood tests.

Serious or Rare Side Effects

  • Bone marrow suppression: pancytopenia leading to infection, bleeding or anemia.
  • Pulmonary toxicity: interstitial pneumonitis presenting with cough and dyspnea.
  • Severe hepatotoxicity: fibrosis or cirrhosis with prolonged use.

Precautions & Warnings

When prescribing methotrexate, clinicians should observe several safety measures to minimize risks.

  • Pregnancy: contraindicated (Category X) due to teratogenic potential.
  • Renal function: assess creatinine clearance; dose adjustment may be required.
  • Hepatic disease: monitor liver function tests regularly.
  • Concomitant NSAIDs: avoid or use with caution as they may increase toxicity.
  • Immunosuppression: monitor for signs of infection and advise patients to report fevers promptly.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Methotrexate interacts with several medicines that can alter its efficacy or increase toxicity.

Major Interactions (Avoid)

  • Live vaccines: may cause severe infection due to immunosuppression.
  • High‑dose aspirin or NSAIDs: increase methotrexate plasma levels and risk of toxicity.
  • Proton pump inhibitors (omeprazole, esomeprazole): may reduce renal clearance and raise serum concentrations.

Moderate Interactions (Monitor Closely)

  • Sulfonamide antibiotics (trimethoprim‑sulfamethoxazole): can enhance myelosuppression.
  • Azathioprine or other immunosuppressants: additive bone marrow suppression.
  • Penicillins (amoxicillin): may modestly increase methotrexate levels.

Frequently Asked Questions

Ledertrexato, containing methotrexate, is prescribed for several autoimmune and oncologic conditions. It is approved for rheumatoid arthritis and psoriasis to control inflammation, and for cancers such as acute lymphoblastic leukemia, non‑Hodgkin lymphoma, and gestational trophoblastic disease where it helps achieve remission.

Methotrexate blocks the enzyme dihydrofolate reductase, which is essential for producing tetrahydrofolate, a key cofactor in DNA, RNA and protein synthesis. By limiting these building blocks, the drug hampers the growth of rapidly dividing cells, providing anti‑inflammatory effects in autoimmune disease and cytotoxic effects in cancer.

The dose of Ledertrexato is individualized by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and response to therapy. Dose adjustments may be required over time, and the prescriber will set the exact regimen according to clinical guidelines.

Methotrexate is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because of a high risk of fetal malformations and miscarriage. It is also not recommended for breastfeeding mothers, as it can be excreted in milk and affect the infant.

To order Ledertrexato, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Ledertrexato (methotrexate) is one of the most widely used antimetabolites because of its oral formulation and broad therapeutic range. Compared with agents like 5‑fluorouracil or cytarabine, methotrexate offers both anti‑inflammatory and anticancer activity, but it requires careful monitoring of liver, kidney and bone‑marrow function.

Ledertrexato tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Ledertrexato is taken orally with a full glass of water, usually once weekly for many indications. Some clinicians advise taking it on an empty stomach or with folic acid supplementation to reduce gastrointestinal irritation, but the exact schedule is determined by the prescribing physician.

The most critical risks include bone‑marrow suppression leading to pancytopenia, severe liver toxicity that can progress to fibrosis or cirrhosis, and pulmonary toxicity such as interstitial pneumonitis. Patients should be monitored regularly with blood counts, liver function tests and, if respiratory symptoms develop, appropriate imaging.

Ledertrexato is contraindicated in pregnant women, individuals with severe renal or hepatic impairment, patients with known hypersensitivity to methotrexate, and those receiving live vaccines. Caution is also advised for patients with pre‑existing lung disease or uncontrolled infections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Methotrexate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT