Product image of Ledraxen (Enoxaparin Sodium) supplied by GNH India

Ledraxen

Active Ingredient:
Enoxaparin Sodium
Origin:
EU

Ledraxen (Enoxaparin Sodium)

Enoxaparin Sodium, the active ingredient in Ledraxen, is a low molecular weight heparin presented as a sterile injectable solution for subcutaneous and intravenous use. It is employed to prevent and treat thromboembolic disorders such as deep vein thrombosis and pulmonary embolism, and to reduce clot formation during haemodialysis.

GNH India supplies Ledraxen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Venipharm

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Indications & Clinical Uses

Ledraxen, a low molecular weight heparin, acts on the coagulation cascade to reduce clot formation in several clinical settings.

  • Deep vein thrombosis (DVT) prophylaxis: prevents clot formation in surgical patients at risk of DVT.
  • Acute DVT and pulmonary embolism (PE) treatment: facilitates clot resolution and reduces recurrence.
  • Haemodialysis clot prophylaxis: minimizes clotting in the extracorporeal circuit during dialysis sessions.

How It Works

  • Enoxaparin Sodium binds to antithrombin III, enhancing its inhibition of factor Xa and, to a lesser extent, factor IIa (thrombin). This accelerated inhibition reduces the conversion of prothrombin to thrombin and limits fibrin formation, thereby preventing the development and propagation of thrombi in the vascular system.

Side Effects

Common Side Effects

  • Injection site erythema or bruising.
  • Mild gastrointestinal bleeding.
  • Nausea or vomiting.
  • Elevated liver enzymes.
  • Transient headache.
  • Localized pain at the injection site.

Serious or Rare Side Effects

  • Major hemorrhage, including intracranial or gastrointestinal bleeding.
  • Heparin‑induced thrombocytopenia (HIT).
  • Allergic reactions such as urticaria or anaphylaxis.
  • Spinal or epidural hematoma following neuraxial procedures.
  • Severe hypotension.
  • Disseminated intravascular coagulation (DIC).

Precautions & Warnings

Ledraxen should be used with caution in patients with renal impairment, active bleeding, or a history of heparin‑induced thrombocytopenia.

  • Renal impairment: adjust dose or monitor anti‑Xa levels.
  • Active bleeding: avoid use unless benefits outweigh risks.
  • Concomitant anticoagulants: increase bleeding risk; monitor coagulation parameters.
  • Platelet monitoring: check counts regularly to detect HIT.
  • Obesity or extreme body weight: consider dose adjustments.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Enoxaparin may interact with several drug classes, influencing bleeding risk or anticoagulant effect.

Major Interactions (Avoid)

  • Concurrent use with other anticoagulants (e.g., warfarin, direct thrombin inhibitors).
  • Combination with antiplatelet agents (e.g., aspirin, clopidogrel) that heighten bleeding.
  • Use with fibrinolytic therapy (e.g., alteplase) may cause severe hemorrhage.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs) that can increase gastrointestinal bleeding.
  • Selective serotonin reuptake inhibitors (SSRIs) that may impair platelet function.
  • ACE inhibitors or angiotensin receptor blockers that can potentiate hypotensive effects when combined with anticoagulation.

Frequently Asked Questions

Ledraxen is a low molecular weight heparin indicated for the prevention of deep vein thrombosis in surgical patients, the treatment of acute deep vein thrombosis and pulmonary embolism, and the prophylaxis of clot formation during haemodialysis procedures.

Enoxaparin Sodium binds to antithrombin III, accelerating its inhibition of factor Xa and, to a lesser extent, factor IIa (thrombin). This reduces thrombin generation and fibrin formation, thereby limiting clot development in the circulatory system.

The specific dose of Ledraxen is determined by the prescribing clinician based on the patient’s indication, weight, renal function, and overall risk profile. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for Enoxaparin Sodium in pregnancy and lactation are limited. Use is generally reserved for situations where the benefit to the mother outweighs potential risks to the fetus or infant, and only under medical supervision.

To order Ledraxen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Compared with unfractionated heparin, Ledraxen offers more predictable pharmacokinetics, a longer half‑life, and does not require routine laboratory monitoring in most patients. Unlike oral agents such as warfarin, it provides rapid anticoagulation via subcutaneous or intravenous routes, making it suitable for acute settings.

Ledraxen should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze the solution, and keep it out of reach of children.

Ledraxen is administered by subcutaneous injection or intravenous infusion, depending on the clinical indication. The injection site is typically the abdomen, and the dose is prepared using sterile technique as directed by the prescribing healthcare professional.

The most serious risks include major bleeding events such as intracranial or gastrointestinal hemorrhage, heparin‑induced thrombocytopenia (HIT), and rare spinal or epidural hematomas, especially after neuraxial procedures. Prompt medical attention is required if these complications are suspected.

Ledraxen is contraindicated in patients with known hypersensitivity to enoxaparin or any heparin product, active major bleeding, or a history of heparin‑induced thrombocytopenia. Caution is also advised for individuals with severe renal impairment or uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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