Product image of Ledraxen (Enoxaparin Sodium) supplied by GNH India

Ledraxen

Active Ingredient:
Enoxaparin Sodium
Origin:
EU

Ledraxen (Enoxaparin Sodium)

Enoxaparin sodium, the active ingredient in Ledraxen, is a low molecular weight heparin presented as a sterile solution for subcutaneous, intravenous and haemodialysis use. It prevents and treats thromboembolic disorders in patients at risk of clot formation.

GNH India supplies Ledraxen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Venipharm

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Indications & Clinical Uses

Ledraxen (enoxaparin sodium) is used in the anticoagulation pathway to prevent and treat venous thromboembolism.

  • Deep vein thrombosis (DVT) prevention: reduces the risk of clot formation in at‑risk patients.
  • Acute deep vein thrombosis treatment: limits clot extension and recurrence.
  • Pulmonary embolism prevention and treatment: stops clot migration to the lungs and resolves existing emboli.
  • Anticoagulation during haemodialysis: maintains circuit patency and minimizes clotting during the procedure.

How It Works

  • Enoxaparin sodium binds to antithrombin III, markedly enhancing its inhibition of activated factor Xa and, to a lesser extent, factor IIa (thrombin). This action diminishes thrombin generation and fibrin clot formation, providing anticoagulation without directly affecting platelet function.

Side Effects

Adverse reactions may occur with enoxaparin sodium therapy.

Common Side Effects

  • Injection site pain or bruising: mild local discomfort at the injection site.
  • Minor bleeding: such as epistaxis, gum bleeding, or easy bruising.
  • Nausea or vomiting: gastrointestinal upset in some patients.
  • Elevated liver enzymes: transient increase in hepatic transaminases.

Serious or Rare Side Effects

  • Major bleeding: life‑threatening hemorrhage including intracranial or gastrointestinal bleeding.
  • Heparin‑induced thrombocytopenia (HIT): immune‑mediated platelet drop with paradoxical clot risk.
  • Allergic reactions: urticaria, angioedema, or anaphylaxis.
  • Spinal or epidural hematoma: bleeding in the spinal canal after neuraxial procedures.

Precautions & Warnings

Use of Ledraxen requires careful clinical assessment and monitoring.

  • Renal impairment: adjust dose or avoid in severe renal dysfunction.
  • Pregnancy: Category B; use only when benefit outweighs potential risk.
  • Surgery or invasive procedures: discontinue appropriately to reduce bleeding risk.
  • Concomitant anticoagulants or antiplatelet agents: increased risk of hemorrhage; monitor closely.
  • Platelet monitoring: watch for thrombocytopenia, especially HIT.
  • Store below 25°C: keep in original carton, protect from moisture and light.

Avoid Interactions

Enoxaparin sodium can interact with several drug classes, affecting bleeding risk.

Major Interactions (Avoid)

  • Concurrent use with other systemic anticoagulants (e.g., warfarin, direct thrombin inhibitors): may cause severe bleeding.
  • Neuraxial anesthesia or spinal puncture: heightened risk of spinal/epidural hematoma.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (aspirin, clopidogrel): increase bleeding tendency.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may exacerbate gastrointestinal bleeding.
  • Selective serotonin reuptake inhibitors (SSRIs) or serotonin‑norepinephrine reuptake inhibitors (SNRIs): can potentiate bleeding risk.

Frequently Asked Questions

Ledraxen contains enoxaparin sodium, a low molecular weight heparin used to prevent and treat deep vein thrombosis, pulmonary embolism, and to provide anticoagulation during haemodialysis procedures.

Enoxaparin sodium enhances the activity of antithrombin III, which in turn inhibits factor Xa and, to a lesser extent, factor IIa (thrombin). This reduces thrombin generation and fibrin clot formation, delivering an anticoagulant effect.

The dose of Ledraxen is individualized by the prescribing clinician based on the specific indication, patient weight, renal function, and clinical setting. Exact dosing regimens are determined by the treating healthcare professional.

Ledraxen is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are no adequate human studies. It should be used in pregnancy only if the potential benefit justifies the potential risk, and breastfeeding decisions should be made in consultation with a healthcare provider.

To order Ledraxen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Compared with unfractionated heparin, enoxaparin (Ledraxen) offers more predictable pharmacokinetics, once‑ or twice‑daily dosing, and a lower risk of heparin‑induced thrombocytopenia. Relative to direct oral anticoagulants, it requires injection but provides rapid onset and is reversible with protamine sulfate.

Ledraxen should be stored below 25 °C in its original packaging, protected from moisture and light. Do not freeze the product. Before use, inspect the solution for particulate matter or discoloration and use aseptic technique for subcutaneous or intravenous administration.

Ledraxen is supplied as a sterile injectable solution and is administered subcutaneously, intravenously, or via the haemodialysis circuit, according to the clinical indication and prescriber’s instructions. Proper injection technique and site rotation are important to minimize local reactions.

The most serious risks include major bleeding events such as intracranial or gastrointestinal hemorrhage, heparin‑induced thrombocytopenia (HIT), and spinal or epidural hematoma following neuraxial procedures. Prompt medical attention is required if any of these occur.

Ledraxen is contraindicated in patients with active major bleeding, known hypersensitivity to enoxaparin or other LMWHs, and those with severe uncontrolled hypertension. Caution is also advised for individuals with a history of HIT or severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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