Product image of Leflokin (Levofloxacin Hemihydrate) supplied by GNH India

Leflokin

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Leflokin (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Leflokin, is a Fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats bacterial infections such as urinary tract infections, community‑acquired pneumonia, acute bacterial sinusitis, skin and soft tissue infections, and prostatitis in adults.

GNH India supplies Leflokin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Gyógyszergyár Zrt

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Indications & Clinical Uses

Levofloxacin is a fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria.

  • Urinary tract infection: eradicates the causative bacteria, relieving symptoms and preventing complications.
  • Community‑acquired pneumonia: eliminates the pathogen, improving lung function and reducing fever.
  • Acute bacterial sinusitis: clears sinus infection, alleviating congestion and facial pain.
  • Skin and soft tissue infection: resolves bacterial involvement, promoting wound healing.
  • Prostatitis: treats bacterial prostatitis, reducing inflammation and urinary discomfort.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By binding to these enzymes, it prevents the supercoiling and separation of DNA strands, halting bacterial cell division and leading to bacterial death. This bactericidal action is effective against a broad range of Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Abdominal pain
  • Rash

Serious or Rare Side Effects

  • Tendon rupture or inflammation
  • QT interval prolongation leading to arrhythmia
  • Clostridioides difficile‑associated colitis
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Peripheral neuropathy
  • Elevated liver enzymes or hepatitis

Precautions & Warnings

Before prescribing Leflokin, clinicians should consider several safety factors.

  • Renal impairment: adjust dose or monitor renal function.
  • History of tendon disorders: avoid use due to risk of tendon rupture.
  • QT prolongation risk: monitor ECG in patients with cardiac arrhythmias.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Concomitant medications: review for interactions that may affect levofloxacin levels.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Levofloxacin can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Ciprofloxacin: additive risk of QT prolongation.
  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase central nervous system side effects.
  • Theophylline: levofloxacin can raise serum theophylline concentrations.
  • Cyclosporine: may lead to higher cyclosporine levels, requiring dose adjustment.

Frequently Asked Questions

Leflokin contains levofloxacin, a broad‑spectrum fluoroquinolone antibiotic indicated for treating adult bacterial infections such as urinary tract infections, community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, and prostatitis.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. Inhibiting these enzymes stops bacterial cell division, leading to bacterial death and resolution of the infection.

The specific dose of Leflokin is determined by the prescribing healthcare professional based on the infection type, severity, patient age, renal function, and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Safety data for levofloxacin in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and only under direct medical supervision.

To order Leflokin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any needed import documentation.

Leflokin (levofloxacin) offers a once‑daily dosing option and a broad spectrum that includes many Gram‑negative and Gram‑positive pathogens. Compared with older fluoroquinolones, it often provides higher potency against respiratory pathogens and a more convenient dosing schedule, though safety considerations remain similar across the class.

Store Leflokin at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Leflokin is taken orally as a tablet. Swallow the tablet whole with a full glass of water; it may be taken with or without food, unless the prescriber advises otherwise.

Serious risks include tendon rupture or inflammation, QT interval prolongation that can cause arrhythmias, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they experience sudden joint pain, palpitations, severe rash, or persistent diarrhea.

Leflokin should be avoided in individuals with known hypersensitivity to levofloxacin or other fluoroquinolones, a history of tendon disorders, uncontrolled cardiac arrhythmias, or those taking medications that significantly prolong the QT interval. Pregnant or breastfeeding women should use it only when clearly indicated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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