Leflon (Leflunomide)

Leflunomide blocks the enzyme dihydroorotate dehydrogenase, which is essential for de novo pyrimidine synthesis. By limiting pyrimidine production, the drug reduces the proliferation of activated lymphocytes, thereby dampening the immune response that drives inflammatory arthritis.

The dosing regimen for Leflon is determined by the prescribing clinician based on the patient’s condition, disease severity, and individual response. Physicians typically start with a loading dose followed by a maintenance dose, but the exact schedule must be individualized.

Leflon is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as leflunomide can be excreted in breast milk and may affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Leflon. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

The primary alternative to leflunomide is methotrexate, another conventional DMARD. While both reduce disease activity, leflunomide has a once‑daily oral dosing schedule and may be preferred when methotrexate is poorly tolerated. However, leflunomide carries a higher risk of liver toxicity and teratogenicity, requiring careful monitoring.

Leflon tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged.

Leflon is taken orally as a tablet, usually with a full glass of water. It can be taken with or without food, but consistent administration with respect to meals helps maintain stable drug levels.

The most serious adverse events include severe liver injury, bone‑marrow suppression leading to anemia or neutropenia, serious infections due to immunosuppression, pulmonary toxicity, and teratogenic effects that can cause fetal malformations. Prompt medical attention is required if any of these occur.

Leflon should not be used by pregnant women, individuals with severe liver disease, patients with active infections, or those who are immunocompromised. It is also contraindicated in patients who have previously experienced severe hypersensitivity reactions to leflunomide.