Leflon (Leflunomide)

Leflunomide blocks the enzyme dihydroorotate dehydrogenase, which is required for the synthesis of pyrimidine nucleotides. This inhibition limits the proliferation of activated T‑cells, thereby dampening the immune response that drives inflammation and joint destruction in rheumatoid and psoriatic arthritis.

The dosage of Leflon is individualized by the prescribing clinician based on the patient’s clinical status, laboratory results, and tolerance. Physicians typically start with a loading dose followed by a maintenance dose, but the exact regimen should be confirmed with the treating healthcare professional.

Leflon is classified as pregnancy category X, meaning it is contraindicated during pregnancy because of a high risk of fetal harm. It is also not recommended for breastfeeding mothers, as leflunomide can be excreted in breast milk and may affect the infant.

To order Leflon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The most common alternative to leflunomide is methotrexate, another DMARD. While both reduce disease activity, leflunomide is taken orally once daily and may be preferred in patients who cannot tolerate methotrexate’s weekly dosing or its hepatic profile. Choice depends on individual efficacy, safety, and physician judgment.

Leflon should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the tablets out of reach of children and do not use the product after the expiration date printed on the label.

Leflon is administered orally as a tablet, usually swallowed whole with a glass of water. It can be taken with or without food, but patients should follow the prescribing physician’s instructions regarding timing and any accompanying medications.

The most serious adverse events associated with Leflon include liver toxicity (elevated liver enzymes or hepatitis), severe infections due to immunosuppression, and pulmonary toxicity such as interstitial lung disease. Patients should report symptoms like jaundice, persistent fever, cough, or shortness of breath promptly.

Leflon is contraindicated in pregnant women, individuals with severe liver disease, patients with known hypersensitivity to leflunomide or its excipients, and those with active, uncontrolled infections. Caution is also advised for patients with a history of pulmonary disease or significant hypertension.