Product image of Leflunomid Bluefish (Leflunomide) supplied by GNH India

Leflunomid Bluefish

Active Ingredient:
Leflunomide
Origin:
EU

Leflunomid Bluefish (Leflunomide)

Leflunomide, the active ingredient in Leflunomid Bluefish, is a disease-modifying antirheumatic drug (DMARD) presented as an oral tablet for oral use. It treats rheumatoid arthritis and psoriatic arthritis in adult patients.

GNH India supplies Leflunomid Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

Leflunomide is a DMARD that modulates immune activity in inflammatory joint diseases.

  • Rheumatoid arthritis: reduces disease activity, slows joint damage, and improves functional status.
  • Psoriatic arthritis: alleviates joint inflammation and skin lesions, helping achieve disease control.
  • Inadequate response to conventional DMARDs: provides an alternative therapeutic option for adults with persistent disease activity.

How It Works

  • Leflunomide is converted to its active metabolite teriflunomide, which inhibits dihydroorotate dehydrogenase, a key enzyme in de novo pyrimidine synthesis. This blockade limits proliferation of activated lymphocytes, thereby reducing the autoimmune response that drives joint inflammation and damage in rheumatoid and psoriatic arthritis.

Side Effects

Leflunomid Bluefish may cause a range of adverse reactions. Patients should be monitored regularly for both common and serious events.

Common Side Effects

  • Diarrhoea: mild to moderate gastrointestinal upset.
  • Nausea: occasional feeling of queasiness.
  • Alopecia: reversible hair thinning.
  • Elevated liver enzymes: mild transaminase rise.
  • Hypertension: increase in blood pressure readings.
  • Rash: non‑specific skin eruption.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, hepatic failure.
  • Stevens‑Johnson syndrome/toxic epidermal necrolysis: severe skin reactions.
  • Bone marrow suppression: pancytopenia, neutropenia.
  • Interstitial lung disease: cough, dyspnoea, pulmonary infiltrates.
  • Serious infections: opportunistic bacterial or viral infections.
  • Teratogenicity: fetal malformations when exposure occurs in pregnancy.

Precautions & Warnings

Leflunomid Bluefish requires careful monitoring and specific safety measures.

  • Pregnancy contraindication: avoid use in women who are pregnant or may become pregnant; teratogenic risk is high.
  • Liver function monitoring: obtain baseline tests and repeat regularly during therapy.
  • Hematologic monitoring: perform complete blood counts to detect bone‑marrow suppression.
  • Renal impairment: adjust use in patients with severe renal dysfunction.
  • Active infection: defer initiation until infection resolves.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Leflunomid Bluefish can interact with several medicines, affecting safety or efficacy.

Major Interactions (Avoid)

  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Cholestyramine or colestipol: reduces leflunomide absorption, lowering therapeutic levels.
  • Live vaccines: heightened risk of infection due to immunosuppression.
  • Hepatotoxic drugs (e.g., azathioprine, methotrexate): additive liver injury.
  • Strong CYP1A2 inhibitors: may raise teriflunomide concentrations.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may exacerbate hypertension and renal effects.
  • ACE inhibitors or ARBs: potential for increased blood pressure.
  • Statins: possible additive liver enzyme elevation.
  • Oral contraceptives: reduced efficacy, consider alternative contraception.
  • Immunosuppressants (e.g., cyclosporine): monitor for enhanced immunosuppression.

Frequently Asked Questions

Leflunomid Bluefish contains leflunomide, a disease‑modifying antirheumatic drug indicated for the treatment of rheumatoid arthritis and psoriatic arthritis in adult patients. It helps reduce joint inflammation, prevent structural damage, and improve overall functional ability.

Leflunomide is metabolised to teriflunomide, which blocks the enzyme dihydroorotate dehydrogenase. This inhibition stops de novo pyrimidine synthesis, limiting the proliferation of activated lymphocytes that drive the autoimmune response in inflammatory arthritis.

The specific dose and dosing schedule are determined by the prescribing clinician based on the individual’s disease severity, response, and safety profile. Healthcare professionals adjust the regimen according to clinical guidelines and patient monitoring.

Leflunomid Bluefish is classified as pregnancy category X, meaning it is contraindicated in pregnancy due to a high risk of fetal malformations. It is also not recommended while breastfeeding because the drug can be excreted in milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Leflunomide differs from traditional DMARDs like methotrexate by targeting pyrimidine synthesis rather than folate metabolism. It offers an oral alternative with a distinct safety profile, but clinicians consider factors such as liver toxicity, teratogenic risk, and drug‑interaction potential when selecting therapy.

Leflunomid Bluefish should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve tablet integrity and potency throughout its shelf life.

The medication is taken orally, usually as a tablet, with or without food as directed by the prescriber. Patients should follow the dosing instructions provided by their healthcare professional and not alter the regimen without medical advice.

Serious risks include severe liver injury, life‑threatening skin reactions such as Stevens‑Johnson syndrome, bone‑marrow suppression leading to pancytopenia, interstitial lung disease, and teratogenic effects. Prompt reporting of any concerning symptoms to a healthcare provider is essential.

Leflunomid Bluefish is contraindicated in pregnant women, individuals with severe liver disease, uncontrolled hypertension, active infections, or known hypersensitivity to leflunomide or any of its components. It should also be avoided in patients planning pregnancy without appropriate contraception.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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