Leflunomide Tillomed (Leflunomide)

Leflunomide is metabolised to teriflunomide, which selectively inhibits the mitochondrial enzyme dihydroorotate dehydrogenase. This inhibition blocks de novo pyrimidine synthesis, reducing the proliferation of activated lymphocytes that drive the autoimmune response in rheumatoid and psoriatic arthritis.

The dosing regimen for leflunomide is determined by the prescribing physician based on the individual’s clinical condition, disease severity, and response to therapy. Physicians typically start with a loading dose followed by a maintenance dose, but exact amounts should only be set by a qualified healthcare professional.

Leflunomide is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because of a high risk of fetal malformations and embryotoxicity. It is also not recommended for breastfeeding mothers, as the drug can be excreted in breast milk and may harm the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Leflunomide Tillomed. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with methotrexate, another first‑line DMARD, leflunomide offers a different mechanism—blocking pyrimidine synthesis rather than folate metabolism. It may be chosen when methotrexate is poorly tolerated or contraindicated. Biologic agents target specific cytokines and are generally reserved for patients who do not respond adequately to conventional DMARDs like leflunomide.

Leflunomide Tillomed tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Leflunomide Tillomed is administered orally as a tablet. Patients should swallow the tablet whole with water, and it may be taken with or without food according to the prescriber’s instructions. Consistency in timing each dose helps maintain stable drug levels.

The most serious risks include severe liver injury, bone marrow suppression (which can lead to anemia, neutropenia, or thrombocytopenia), and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Additionally, the drug is teratogenic, so strict contraception is required for women of childbearing potential.

Leflunomide should not be used by pregnant women, individuals with severe hepatic impairment, patients with active serious infections, or those with known hypersensitivity to leflunomide or its metabolites. Caution is also advised for patients with uncontrolled hypertension or a history of bone marrow disorders.