Product image of Lefunzol (Fluconazole) supplied by GNH India

Lefunzol

Active Ingredient:
Fluconazole
Origin:
EU

Lefunzol (Fluconazole)

Fluconazole, the active ingredient in Lefunzol, is an azole antifungal presented as an oral tablet for oral use. It treats a range of fungal infections, including candidiasis of the mouth, esophagus and vagina, as well as systemic and cryptococcal infections.

GNH India supplies Lefunzol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance, regulatory compliance and reliable logistics for global healthcare providers through a network of certified distributors and dedicated support teams continually.

Manufacturer / TM Owner

Epifarma S.R.L.

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Indications & Clinical Uses

Fluconazole is an azole antifungal that interferes with fungal cell membrane synthesis, making it effective for several invasive and mucosal fungal diseases.

  • Candidiasis (oropharyngeal, esophageal, vaginal): Reduces fungal burden and alleviates symptoms in mucosal yeast infections.
  • Cryptococcal meningitis: Provides systemic antifungal activity to treat central nervous system infection caused by Cryptococcus species.
  • Systemic fungal infections: Acts against a broad range of pathogenic yeasts and molds in disseminated disease.

How It Works

  • Fluconazole inhibits the fungal cytochrome P450 enzyme 14α‑demethylase, a key step in ergosterol synthesis. By blocking this enzyme, the drug disrupts the formation of ergosterol, an essential component of the fungal cell membrane, leading to increased membrane permeability, impaired cell growth and ultimately fungal cell death. The inhibition is dose‑dependent and selective for fungal enzymes, resulting in minimal impact on human sterol pathways.

Side Effects

Fluconazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset often reported.
  • Headache: transient cranial discomfort.
  • Diarrhea: loose stools that usually resolve.
  • Abdominal pain: cramping or discomfort in the stomach area.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiac arrhythmias: QT prolongation leading to irregular heartbeat.

Precautions & Warnings

Before prescribing fluconazole, clinicians should evaluate several safety considerations to minimize risk.

  • Pregnancy: Use only if benefits outweigh risks; classified Category D due to potential fetal harm.
  • Liver disease: Adjust therapy and monitor hepatic function in patients with pre‑existing liver impairment.
  • Renal impairment: Dose may need modification in severe kidney dysfunction.
  • Drug interactions: Review concomitant medications for potential CYP450 interactions.
  • Allergic reactions: Discontinue if signs of hypersensitivity such as rash or swelling appear.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture.

Avoid Interactions

Fluconazole can affect the metabolism of other drugs, requiring careful management of co‑administered therapies.

Major Interactions (Avoid)

  • Cisapride: risk of serious cardiac arrhythmias.
  • Pimozide: may cause QT prolongation and arrhythmias.
  • Certain statins (e.g., lovastatin, simvastatin): increased risk of myopathy.

Moderate Interactions (Monitor Closely)

  • Warfarin: fluconazole can increase INR, requiring dose adjustment.
  • Phenytoin: may reduce fluconazole levels, decreasing efficacy.
  • Oral contraceptives: may decrease hormonal effectiveness, consider backup contraception.

Frequently Asked Questions

Lefunzol contains fluconazole, an azole antifungal indicated for the treatment of mucosal candidiasis (including oropharyngeal, esophageal and vaginal infections), cryptococcal meningitis, and a variety of systemic fungal infections caused by susceptible yeasts and molds.

Fluconazole inhibits the fungal cytochrome P450 enzyme 14α‑demethylase, blocking ergosterol synthesis. This disrupts the fungal cell membrane, increasing its permeability, impairing growth and ultimately leading to fungal cell death.

The prescribed dose of Lefunzol is set by the treating clinician based on the type and severity of the infection, patient weight, renal and hepatic function, and any relevant drug‑interaction considerations. No fixed dosing can be stated without a prescription.

Fluconazole is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It should be used in pregnancy only when the potential benefit justifies the risk. Limited data are available for breastfeeding; the decision should be made with a healthcare professional.

To order Lefunzol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other azoles such as itraconazole or voriconazole, fluconazole (Lefunzol) has a longer half‑life, excellent oral bioavailability and a relatively favorable safety profile, but it may be less potent against certain resistant fungi. Choice of therapy depends on the pathogen, infection site and patient factors.

Lefunzol tablets should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children.

Lefunzol is taken orally, usually with a full glass of water. It can be taken with or without food, unless the prescribing clinician advises otherwise. Swallow the tablet whole; do not crush or chew unless specifically instructed.

Serious adverse effects include hepatotoxicity (elevated liver enzymes or liver injury), severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and cardiac arrhythmias due to QT‑interval prolongation. Patients should be monitored for signs of these conditions.

Lefunzol should be avoided in individuals with known hypersensitivity to fluconazole or other azole antifungals, in patients with severe liver dysfunction, and in pregnant women unless the therapeutic benefit outweighs the fetal risk. Caution is also advised for patients with significant cardiac disease or electrolyte disturbances.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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