Product image of Lekadol Combo (Phenylephrine Hydrochloride, Paracetamol) supplied by GNH India

Lekadol Combo

Active Ingredient:
Phenylephrine Hydrochloride, Paracetamol
Origin:
EU

Lekadol Combo (Phenylephrine Hydrochloride, Paracetamol)

Phenylephrine Hydrochloride, the active ingredient in Lekadol Combo, is a combination analgesic/antipyretic and decongestant presented as an oral tablet for oral use. It provides relief from pain, fever, and nasal congestion associated with common colds and similar conditions.

GNH India supplies Lekadol Combo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams across multiple markets worldwide. The company adheres to stringent quality standards and provides regulatory support for import and distribution. This ensures timely delivery and product integrity.

Manufacturer / TM Owner

Sandoz D.O.O.

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Indications & Clinical Uses

Lekadol Combo, a combination analgesic/antipyretic and decongestant, is used to manage symptoms of common cold and related conditions.

  • Headache: reduces pain associated with tension or mild migraine.
  • Fever: lowers elevated body temperature during infectious or inflammatory states.
  • Common cold symptoms: alleviates overall discomfort such as aches and chills.
  • Nasal congestion: eases blocked nasal passages by shrinking swollen mucosal vessels.

How It Works

  • Paracetamol acts centrally by inhibiting cyclooxygenase enzymes, decreasing prostaglandin synthesis and thereby providing analgesic and antipyretic effects. Phenylephrine Hydrochloride is an alpha‑1 adrenergic agonist that induces vasoconstriction of nasal mucosal blood vessels, reducing swelling and improving airflow.

Side Effects

Adverse reactions may occur with oral use of Lekadol Combo.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dizziness: transient light‑headedness.
  • Headache: occasional worsening of head pain.
  • Dry mouth: reduced salivation.
  • Insomnia: difficulty falling asleep.
  • Mild rash: skin irritation or redness.

Serious or Rare Side Effects

  • Allergic reaction: hives, swelling, or difficulty breathing.
  • Hypertension: sudden increase in blood pressure.
  • Liver injury: elevated liver enzymes or jaundice.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiac arrhythmia: irregular heart rhythm in susceptible individuals.

Precautions & Warnings

Before using Lekadol Combo, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Liver disease: avoid or use only under medical supervision.
  • Hypertension: monitor blood pressure regularly.
  • Drug interactions: review all concurrent medications with a pharmacist.
  • Age restrictions: not recommended for children under the specified age without guidance.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lekadol Combo may interact with other medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Warfarin: increased bleeding risk due to paracetamol.
  • Monoamine oxidase inhibitors: heightened cardiovascular effects.
  • Other decongestants: potential for excessive vasoconstriction.
  • Antihypertensive agents: may reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Alcohol: enhanced liver toxicity.
  • SSRIs or SNRIs: possible increase in blood pressure.
  • Other analgesics: risk of cumulative dosing.
  • Antacids: may affect absorption.
  • Diuretics: monitor electrolyte balance.

Frequently Asked Questions

Lekadol Combo is an over‑the‑counter oral tablet that combines phenylephrine and paracetamol to relieve headache, reduce fever, and ease nasal congestion associated with common colds and mild upper‑respiratory infections.

Phenylephrine is an alpha‑1 adrenergic agonist; it narrows the blood vessels in the nasal mucosa, decreasing swelling and allowing the airways to open, which relieves congestion.

The appropriate dose of Lekadol Combo is determined by a qualified prescriber based on the patient’s age, weight, and clinical condition. Patients should follow the healthcare professional’s instructions and the product label.

Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient products, Lekadol Combo offers both analgesic/antipyretic action (paracetamol) and decongestant activity (phenylephrine) in one tablet, simplifying dosing and potentially improving adherence for patients needing relief from multiple symptoms.

Store Lekadol Combo at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, excessive heat, and direct sunlight to maintain potency.

Lekadol Combo is taken orally with a full glass of water. It may be taken with or without food, unless the prescribing clinician advises otherwise.

Serious risks include allergic reactions such as hives or swelling, significant hypertension, and rare but severe liver injury. Patients should seek immediate medical attention if they experience difficulty breathing, rash, jaundice, or a sudden rise in blood pressure.

Individuals with known hypersensitivity to phenylephrine, paracetamol, or any excipients, those with uncontrolled hypertension, severe liver disease, or who are taking contraindicated medications (e.g., MAO inhibitors) should avoid using Lekadol Combo unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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