Product image of Lekadol Combo (Phenylephrine Hydrochloride, Paracetamol) supplied by GNH India

Lekadol Combo

Active Ingredient:
Phenylephrine Hydrochloride, Paracetamol
Origin:
EU

Lekadol Combo (Phenylephrine Hydrochloride, Paracetamol)

Phenylephrine Hydrochloride and Paracetamol, the active ingredients in Lekadol Combo, are a combination analgesic and nasal decongestant presented as an oral tablet for over‑the‑counter use. They provide relief from headache, fever, minor aches and pains, and nasal congestion in adults and children.

GNH India supplies Lekadol Combo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from consistent product availability and regulatory support across EU and other markets.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

Lekadol Combo, a combination analgesic and nasal decongestant, is indicated for the following conditions:

  • Headache: temporary relief of tension‑type or mild migraine pain.
  • Fever: reduction of elevated body temperature associated with common infections.
  • Minor aches and pains: alleviation of discomfort from muscle strain, backache, toothache or similar mild conditions.
  • Nasal congestion: clearing of blocked nasal passages caused by colds, sinusitis or allergic rhinitis.

How It Works

  • Phenylephrine hydrochloride acts as an alpha‑1 adrenergic agonist, producing vasoconstriction of the nasal mucosal vessels and thereby decreasing swelling and congestion. Paracetamol exerts its analgesic and antipyretic actions primarily through central inhibition of cyclooxygenase enzymes and modulation of serotonergic pathways, leading to reduced pain perception and lowered hypothalamic temperature set‑point.

Side Effects

Common Side Effects

  • Nausea: mild stomach upset that may occur after oral intake.
  • Dizziness: transient light‑headedness, especially when standing quickly.
  • Dry mouth: reduced salivation leading to a feeling of thirst.
  • Mild headache: occasional headache unrelated to the treated condition.

Serious or Rare Side Effects

  • Allergic rash or swelling: signs of hypersensitivity such as hives, facial edema or itching.
  • Severe hypertension: marked increase in blood pressure, particularly in susceptible individuals.
  • Liver function abnormalities: elevated liver enzymes indicating possible hepatic stress.
  • Anaphylactic reaction: rare but life‑threatening systemic allergic response requiring immediate medical attention.

Precautions & Warnings

Before using Lekadol Combo, consider the following precautions:

  • Pregnancy: consult a healthcare professional to assess risk versus benefit.
  • Breastfeeding: use only if the expected benefit to the infant outweighs potential risk.
  • Cardiovascular disease: avoid excessive phenylephrine in patients with hypertension or heart disease.
  • Liver disease: limit paracetamol intake and monitor hepatic function.
  • Drug interactions: review all concurrent medications for possible interactions.
  • Store at ambient temperature: keep below 25 °C, retain in the original packaging, and protect from moisture.

Avoid Interactions

Lekadol Combo may interact with other medicines as follows:

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: risk of hypertensive crisis when combined with phenylephrine.
  • Other sympathomimetic agents: additive vasoconstrictive effects may raise blood pressure.
  • Additional paracetamol‑containing products: increased risk of hepatotoxicity.
  • Warfarin: paracetamol may potentiate anticoagulant effect and raise INR.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: phenylephrine may diminish their efficacy.
  • Selective serotonin reuptake inhibitors: potential for serotonin‑related adverse events.
  • Alcohol: combined use can increase liver stress and enhance sedation.
  • CYP2E1 inducers: may alter paracetamol metabolism, affecting safety profile.

Frequently Asked Questions

Lekadol Combo is an over‑the‑counter oral medication that combines phenylephrine hydrochloride and paracetamol. It is used to relieve common symptoms such as headache, fever, minor aches and pains, and nasal congestion caused by colds or sinus irritation. The product is intended for short‑term use in adults and children when these symptoms arise.

Phenylephrine hydrochloride is a selective alpha‑1 adrenergic receptor agonist. By stimulating these receptors on the blood vessels of the nasal mucosa, it causes vasoconstriction, which reduces swelling and opens the nasal passages. This mechanism helps alleviate the feeling of a blocked or congested nose during colds, allergies, or sinusitis.

The appropriate dose of Lekadol Combo is determined by a qualified healthcare professional based on the patient’s age, weight, and clinical condition. The prescriber will specify the exact amount and frequency to ensure safe and effective use, and patients should follow that guidance without deviation.

Safety data for Lekadol Combo in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the potential risks and benefits with their healthcare provider before using the product. The prescriber may recommend alternative therapies if the risk is deemed unacceptable.

To request Lekadol Combo, visit the product page on gnhindia.com and submit an enquiry specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing a formal quotation, availability details, shipping options, and any necessary import documentation.

Lekadol Combo offers the convenience of a single tablet that delivers both a nasal decongestant (phenylephrine) and an analgesic/antipyretic (paracetamol). Using the combination can simplify dosing when both pain/fever and congestion are present, whereas separate products require taking two different medicines and managing two dosing schedules.

Lekadol Combo should be stored at ambient temperature, ideally below 25 °C (77 °F). Keep the tablets in their original blister pack or container, protect them from moisture and direct sunlight, and ensure they are out of reach of children. Do not use the product after the expiry date printed on the packaging.

Lekadol Combo is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed unless directed by a healthcare professional. It is intended for short‑term relief of symptoms, and the dosing interval and total daily amount should follow the prescriber’s instructions.

Serious risks, although rare, include severe allergic reactions such as rash, swelling, or anaphylaxis, and significant hypertension caused by phenylephrine. Paracetamol can cause liver injury if taken in excess or combined with other hepatotoxic agents. Patients should seek immediate medical attention if they experience any signs of these serious adverse events.

Lekadol Combo should be avoided by individuals with known hypersensitivity to phenylephrine, paracetamol, or any excipients in the tablet. It is also contraindicated in patients with severe uncontrolled hypertension, significant liver disease, or those taking monoamine oxidase inhibitors. Children under the age recommended on the label should not use the product without medical advice.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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