Product image of Lekadol (Paracetamol) supplied by GNH India

Lekadol

Active Ingredient:
Paracetamol
Origin:
EU

Lekadol (Paracetamol)

Paracetamol, the active ingredient in Lekadol, is an analgesic presented as an oral tablet for oral use. It relieves mild to moderate pain and reduces fever in adults and children, with a rapid onset that makes it suitable for common conditions such as headache, musculoskeletal discomfort, and febrile episodes.

GNH India supplies Lekadol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution, offering customers consistent product availability and regulatory expertise.

Manufacturer / TM Owner

Sandoz D.O.O.

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Indications & Clinical Uses

Paracetamol acts on the central nervous system to alleviate pain and lower temperature, making it useful across several common clinical situations.

  • Pain: provides relief of mild to moderate pain such as headache, dental pain, or musculoskeletal discomfort.
  • Fever: reduces elevated body temperature associated with infections or inflammatory conditions.
  • Headache: alleviates tension‑type headache symptoms.
  • Dental pain: offers effective relief after dental procedures.
  • Menstrual cramps: helps reduce discomfort associated with dysmenorrhea.

How It Works

  • Paracetamol inhibits prostaglandin synthesis primarily within the central nervous system by acting on the cyclooxygenase pathway, which reduces the perception of pain and lowers the hypothalamic set‑point for temperature regulation, thereby providing analgesic and antipyretic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Rash: transient skin irritation.
  • Abdominal discomfort: occasional stomach upset.
  • Dizziness: brief episodes of light‑headedness.
  • Headache: paradoxical headache in some users.
  • Elevated liver enzymes: mild, reversible changes.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Toxic epidermal necrolysis: life‑threatening skin detachment.
  • Acute liver failure: especially with overdose or pre‑existing liver disease.
  • Blood disorders: agranulocytosis or thrombocytopenia.
  • Anaphylaxis: rare but potentially fatal allergic reaction.
  • Severe skin reactions: including drug reaction with eosinophilia and systemic symptoms (DRESS).

Precautions & Warnings

When using Lekadol, consider the following safety measures.

  • Assess liver function: evaluate hepatic health before initiating therapy.
  • Avoid alcohol: concurrent use increases risk of hepatotoxicity.
  • Use lowest effective dose: limit exposure while achieving symptom control.
  • Monitor in children: adjust dose carefully and avoid exceeding recommended limits.
  • Do not exceed maximum daily dose: adhere to regulatory limits to prevent toxicity.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Paracetamol may interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Alcohol: combined use heightens risk of liver injury.
  • Warfarin: may enhance anticoagulant effect and increase bleeding risk.
  • Hepatotoxic drugs: concurrent use with other liver‑toxic agents can compound toxicity.

Moderate Interactions (Monitor Closely)

  • Rifampicin: induces metabolism, potentially reducing analgesic efficacy.
  • Phenytoin: may increase clearance, lowering therapeutic effect.
  • Oral contraceptives: may reduce contraceptive reliability.
  • Isoniazid: can alter liver enzyme activity, requiring monitoring.

Frequently Asked Questions

Lekadol contains paracetamol and is used to relieve mild to moderate pain such as headache, dental discomfort, or musculoskeletal aches, and to reduce fever associated with infections or inflammatory conditions. It is an over‑the‑counter option for adults and children when a non‑opioid analgesic is appropriate.

Paracetamol works by inhibiting the synthesis of prostaglandins in the central nervous system, which lowers the brain’s temperature set‑point and diminishes the perception of pain. This action provides analgesic and antipyretic effects without significant anti‑inflammatory activity at typical doses.

The exact dose of Lekadol is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Standard adult regimens often involve a single dose taken every 4–6 hours, not exceeding the maximum daily limit, but the prescriber will specify the appropriate schedule.

Paracetamol is generally considered compatible with pregnancy and lactation when used at recommended doses, but safety cannot be guaranteed for every individual. Healthcare providers should evaluate the risk‑benefit profile for each patient, and women who are pregnant or breastfeeding should follow professional guidance before using Lekadol.

To order Lekadol, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Both Lekadol (paracetamol) and ibuprofen provide pain relief and fever reduction, but they differ in mechanisms and safety profiles. Paracetamol lacks significant anti‑inflammatory activity and is gentler on the stomach, while ibuprofen offers anti‑inflammatory effects but may irritate the gastrointestinal tract and affect renal function. Choice depends on the clinical situation and patient tolerance.

Lekadol should be stored at room temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments to maintain potency.

Lekadol is taken orally, usually as a tablet that is swallowed whole with water. It can be taken with or without food, and the patient should follow the dosing instructions provided by the prescriber or the product label to ensure safe and effective use.

The most serious risks include severe liver injury, especially with overdose or in patients with pre‑existing liver disease, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Prompt medical attention is required if signs of liver dysfunction or severe skin changes appear.

Individuals with known hypersensitivity to paracetamol or any tablet excipients should avoid Lekadol. Patients with severe liver impairment, chronic alcohol misuse, or those taking other hepatotoxic medications should consult a healthcare professional before use, as should anyone who exceeds the recommended daily maximum dose.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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