Product image of Lekadol (Paracetamol) supplied by GNH India

Lekadol

Active Ingredient:
Paracetamol
Origin:
EU

Lekadol (Paracetamol)

Paracetamol, the active ingredient in Lekadol, is an analgesic presented as an oral dosage form for oral use. It reduces pain and fever and is commonly used in adults and children for mild to moderate discomfort, and is available over the counter in many markets.

GNH India supplies Lekadol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers, including bulk shipments and customized packaging options.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

Paracetamol is an analgesic/antipyretic that acts on the central nervous system to relieve pain and reduce fever.

  • Pain: provides relief of mild to moderate pain such as headache, toothache, and musculoskeletal discomfort.
  • Fever: lowers elevated body temperature in febrile conditions.
  • Post‑operative pain: helps manage discomfort after surgical procedures.
  • Cold symptoms: alleviates discomfort associated with common cold and flu.

How It Works

  • Paracetamol exerts its effect by inhibiting cyclooxygenase (COX) enzymes in the central nervous system, which reduces the synthesis of prostaglandins—key mediators of pain and fever. This central inhibition leads to analgesic and antipyretic actions without significant peripheral anti‑inflammatory activity.

Side Effects

Paracetamol may cause adverse reactions, ranging from mild to serious, although it is generally well tolerated.

Common Side Effects

  • Nausea
  • Skin rash
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Severe skin reactions (e.g., Stevens‑Johnson syndrome, toxic epidermal necrolysis)
  • Hepatotoxicity, especially with overdose
  • Blood disorders such as agranulocytosis
  • Anaphylactic reactions

Precautions & Warnings

Paracetamol should be used with caution in certain clinical situations to minimize risk.

  • Assess liver function: avoid use in patients with severe hepatic impairment.
  • Limit alcohol consumption: concurrent intake may increase liver risk.
  • Monitor dosage in children: ensure weight‑based dosing as prescribed.
  • Avoid prolonged high‑dose therapy: risk of liver injury increases with duration.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Paracetamol can interact with several medicines, requiring attention to avoid adverse effects.

Major Interactions (Avoid)

  • Alcohol: combined use heightens risk of liver damage.
  • Warfarin: may potentiate anticoagulant effect, increasing bleeding risk.
  • Carbamazepine: induces metabolism, reducing paracetamol efficacy.

Moderate Interactions (Monitor Closely)

  • Isoniazid: may increase hepatotoxic potential.
  • Phenobarbital: may lower plasma concentrations of paracetamol.
  • Oral contraceptives: may affect hepatic enzyme activity, requiring monitoring.

Frequently Asked Questions

Lekadol contains paracetamol, an OTC analgesic/antipyretic used to relieve mild to moderate pain such as headache, toothache, musculoskeletal pain, and to reduce fever in adults and children, as directed by a healthcare professional.

Paracetamol works by inhibiting the enzyme cyclooxygenase (COX) in the central nervous system, which reduces the synthesis of prostaglandins—chemical mediators that sensitize nerve endings to pain and raise body temperature. This central action provides analgesic and antipyretic effects without significant anti‑inflammatory activity.

The appropriate dose of Lekadol is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and any relevant medical history. Dosage instructions are provided on the product label and should be followed exactly; patients should not adjust the amount without professional guidance.

Safety of paracetamol in pregnancy and lactation is evaluated case by case. Current evidence suggests short‑term use at recommended doses is generally considered low risk, but pregnant or nursing women should consult their healthcare provider before taking Lekadol to confirm that it is appropriate for their specific situation.

To place an order, visit the product page for Lekadol on gnhindia.com, submit an enquiry with the required quantity, and provide institutional or trade credentials. GNH India’s procurement team will verify the information, then respond with pricing, availability, shipping details (including any required temperature control), and assist with import documentation.

Compared with non‑steroidal anti‑inflammatory drugs (NSAIDs) such as ibuprofen, Lekadol (paracetamol) provides analgesic and antipyretic effects without significant anti‑inflammatory activity and carries a lower risk of gastrointestinal irritation. However, unlike NSAIDs, it does not affect platelet function, and its safety profile is primarily linked to liver health, especially at high doses.

Lekadol should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use. Do not store in a refrigerator or freezer unless the label specifically indicates otherwise.

Lekadol is taken orally, usually with a glass of water. The tablet (or other oral form) should be swallowed whole unless the label advises otherwise. It can be taken with or without food, but patients should follow the dosing schedule prescribed by their healthcare professional and avoid exceeding the maximum daily amount.

The most serious risks of Lekadol involve liver injury, which can be severe or fatal in cases of overdose or when combined with other hepatotoxic substances such as alcohol. Rare but life‑threatening skin reactions (e.g., Stevens‑Johnson syndrome) and severe allergic responses like anaphylaxis may also occur. Prompt medical attention is required if any signs of these conditions appear.

Lekadol should be avoided by individuals with known hypersensitivity to paracetamol or any of the product’s excipients. It is also contraindicated in patients with severe hepatic impairment, active liver disease, or chronic alcohol misuse. Children under the recommended age or those for whom a pediatric formulation is not approved should not use the product without specific medical advice.

Published by

GNH India Pharmaceuticals Limited

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Last updated:

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