Product image of Lekofen (Ibuprofen, Paracetamol) supplied by GNH India

Lekofen

Active Ingredient:
Ibuprofen, Paracetamol
Origin:
EU

Lekofen (Ibuprofen, Paracetamol)

Ibuprofen and Paracetamol, the active ingredients in Lekofen, are NSAID and analgesic agents presented as an oral tablet for systemic use. They are used to relieve pain and reduce fever in adults and children.

GNH India supplies Lekofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz D.O.O.

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Indications & Clinical Uses

Lekofen combines ibuprofen and paracetamol to address pain and fever through peripheral and central mechanisms.

  • Pain: provides effective analgesia for mild to moderate discomfort.
  • Fever: lowers elevated body temperature.
  • Headache: alleviates tension‑type and migraine‑associated headache.
  • Musculoskeletal pain: eases inflammation‑related aches in joints and muscles.

How It Works

  • Ibuprofen inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing peripheral prostaglandin synthesis and reducing inflammation. Paracetamol acts primarily in the central nervous system to inhibit prostaglandin formation and modulate pain pathways, producing antipyretic and analgesic effects without significant peripheral anti‑inflammatory activity.

Side Effects

Adverse reactions may occur with oral ibuprofen/paracetamol combinations.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia.
  • Nausea or vomiting.
  • Dizziness or light‑headedness.
  • Mild skin rash or itching.

Serious or Rare Side Effects

  • Severe allergic reactions such as anaphylaxis.
  • Hepatic injury, including elevated liver enzymes.
  • Acute kidney injury or reduced renal function.
  • Gastrointestinal bleeding or ulcer perforation.

Precautions & Warnings

Use Lekofen with awareness of specific safety considerations.

  • Assess renal function: avoid in severe renal impairment.
  • Monitor hepatic status: caution in patients with liver disease.
  • Avoid concurrent NSAIDs: increased risk of gastrointestinal toxicity.
  • Limit alcohol consumption: may enhance hepatotoxic potential.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Lekofen may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • High‑dose corticosteroids: increased ulcer potential.
  • Lithium: ibuprofen can raise serum lithium levels.
  • Methotrexate: ibuprofen may reduce methotrexate clearance.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible renal function alteration.
  • Diuretics: risk of reduced renal perfusion.
  • SSRIs: combined use may increase bleeding tendency.
  • Alcohol: synergistic hepatotoxic effect.
  • Anticonvulsants (e.g., carbamazepine): may affect drug metabolism.

Frequently Asked Questions

Lekofen is indicated for the temporary relief of mild to moderate pain such as headache, musculoskeletal discomfort, and dental pain, as well as for the reduction of fever associated with common infections or inflammatory conditions.

Ibuprofen reduces inflammation by blocking cyclooxygenase enzymes that produce prostaglandins at the site of injury, while paracetamol acts centrally to inhibit prostaglandin synthesis in the brain, providing antipyretic and analgesic effects. The combination offers complementary pain relief through peripheral and central pathways.

The appropriate dose of Lekofen is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lekofen.

To place an order, submit an enquiry on the Lekofen product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lekofen combines ibuprofen with paracetamol, offering broader analgesic coverage. While ibuprofen alone provides anti‑inflammatory and analgesic effects, the addition of paracetamol enhances fever reduction and pain relief, often allowing lower doses of each component compared with single‑ingredient therapy.

Store Lekofen at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, excessive heat and direct sunlight to maintain potency and stability.

Lekofen is taken orally with a full glass of water. It may be taken with or without food, although taking it with food can reduce the likelihood of gastrointestinal discomfort.

Serious risks include severe allergic reactions (anaphylaxis), liver injury, kidney impairment, and gastrointestinal bleeding or ulceration. Patients should seek immediate medical attention if they experience symptoms such as rash, swelling, jaundice, dark urine, or persistent abdominal pain.

Individuals with known hypersensitivity to ibuprofen, paracetamol, or any excipients, those with severe renal or hepatic impairment, active gastrointestinal ulcers, or who are taking anticoagulants without medical supervision should avoid using Lekofen.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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