Product image of Lekofusin (Ibuprofen, Paracetamol) supplied by GNH India

Lekofusin

Active Ingredient:
Ibuprofen, Paracetamol
Origin:
EU

Lekofusin (Ibuprofen, Paracetamol)

Ibuprofen/Paracetamol, the active ingredient in Lekofusin, is a Nonsteroidal anti-inflammatory drug presented as an oral formulation for oral use. It is indicated for the relief of pain, reduction of fever, and mitigation of inflammation in adult patients.\n\nGNH India supplies Lekofusin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

  • Lekofusin combines ibuprofen and paracetamol to act on pain‑related and febrile pathways.\n\nPain: Provides analgesic relief for mild to moderate acute pain such as headache or musculoskeletal discomfort.\nFever: Reduces elevated body temperature associated with viral or bacterial infections.\nInflammation: Decreases localized swelling and discomfort in conditions like minor injuries or arthritic flare‑ups.

How It Works

  • Ibuprofen inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing prostaglandin synthesis that mediates inflammation and pain. Paracetamol acts centrally to inhibit a variant of cyclooxygenase in the brain, lowering the hypothalamic set‑point for temperature and providing additional analgesia. The combined effect yields enhanced pain relief and antipyretic activity compared with either agent alone.

Side Effects

  • Adverse reactions may occur with oral ibuprofen/paracetamol combinations.\n\nCommon Side Effects:\n- Nausea or upset stomach\n- Dyspepsia or heartburn\n- Headache\n- Dizziness\n- Mild skin rash\n- Transient elevation of liver enzymes\n\nSerious or Rare Side Effects:\n- Gastrointestinal bleeding or ulceration\n- Severe hepatic injury\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis\n- Anaphylactic reaction\n- Renal impairment or acute kidney injury\n- Blood dyscrasias such as agranulocytosis

Precautions & Warnings

  • Before using Lekofusin, consider the following safety measures.\n\nRenal function assessment: Evaluate kidney health, especially in patients with chronic renal disease.\nHepatic function assessment: Monitor liver enzymes in patients with existing liver conditions.\nHypersensitivity: Avoid if known allergy to ibuprofen, paracetamol, or other NSAIDs.\nAnticoagulant use: Use caution when combined with warfarin or other blood thinners due to bleeding risk.\nPregnancy trimester: Avoid in the third trimester because of potential fetal complications.\nStore at ambient temperature: Keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

  • Lekofusin may interact with several drug classes.\n\nMajor Interactions (Avoid):\n- Anticoagulants (e.g., warfarin) – increased bleeding risk\n- Other NSAIDs or aspirin – additive gastrointestinal toxicity\n- Lithium – elevated lithium serum levels\n- Methotrexate – reduced clearance leading to toxicity\n- SSRIs or SNRIs – heightened risk of gastrointestinal bleeding\n\nModerate Interactions (Monitor Closely):\n- Antihypertensives – possible reduction in blood pressure effect\n- Diuretics – may impair renal excretion of ibuprofen\n- ACE inhibitors – risk of reduced renal function\n- Corticosteroids – increased ulcer risk\n- Alcohol – potentiates liver toxicity and gastric irritation

Frequently Asked Questions

Lekofusin is an oral combination of ibuprofen and paracetamol that is used to relieve mild to moderate pain, lower fever, and reduce inflammation associated with conditions such as headaches, musculoskeletal aches, and minor injuries.

Ibuprofen blocks cyclooxygenase‑1 and ‑2 enzymes, lowering prostaglandin production that drives pain and inflammation. Paracetamol works centrally to inhibit a brain‑specific cyclooxygenase, resetting the temperature set‑point and adding analgesic effect. Together they provide complementary pain‑relieving and antipyretic actions.

The appropriate dose of Lekofusin is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and other medications. Patients should follow the prescriber’s instructions and not exceed the recommended amount.

Safety of Lekofusin in pregnancy or lactation has not been fully established. It should be avoided in the third trimester and used only if clearly needed in earlier trimesters after a risk‑benefit assessment. Breastfeeding mothers should consult their physician before use.

To order Lekofusin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with single‑ingredient ibuprofen or paracetamol products, Lekofusin offers combined analgesic and antipyretic effects, potentially achieving better pain control at lower individual doses. However, the combination may carry a broader safety profile, requiring attention to renal, hepatic and gastrointestinal risks.

Lekofusin should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack, protect them from moisture and direct sunlight, and keep out of reach of children.

Lekofusin is taken orally with a full glass of water. It may be taken with or without food, although taking it with food can reduce gastrointestinal discomfort. The exact timing and frequency should follow the prescribing clinician’s directions.

Serious risks include gastrointestinal bleeding or ulceration, severe liver injury, allergic reactions such as anaphylaxis, and renal impairment. Patients should seek immediate medical attention if they notice signs of bleeding, jaundice, rash, or sudden loss of kidney function.

Lekofusin should not be used by individuals with known hypersensitivity to ibuprofen, paracetamol, or any NSAID, those with active gastrointestinal ulcers, severe liver or kidney disease, and during the third trimester of pregnancy. Consultation with a healthcare professional is essential for anyone with chronic medical conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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