Product image of Lekoklar (Clarithromycin) supplied by GNH India

Lekoklar

Active Ingredient:
Clarithromycin
Origin:
EU

Lekoklar (Clarithromycin)

Clarithromycin, the active ingredient in Lekoklar, is a macrolide antibiotic presented as an oral tablet for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, and is used in combination regimens for Helicobacter pylori eradication in adult patients.

GNH India supplies Lekoklar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Pharmaceuticals D.D.

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic used to treat bacterial infections in various organ systems.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation by eliminating pathogenic microbes.
  • Skin and soft‑tissue infections: clears Staphylococcus and Streptococcus species from affected tissues.
  • Helicobacter pylori eradication (in combination therapy): contributes to bacterial clearance as part of a multi‑drug regimen.

How It Works

  • Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing translocation of the peptidyl‑tRNA. This blockade halts peptide chain elongation, leading to bacteriostatic activity against susceptible Gram‑positive and some Gram‑negative organisms.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: frequent loose stools.
  • Abdominal pain: cramping or discomfort.
  • Taste disturbance: altered or metallic taste.
  • Headache: mild tension‑type headache.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • QT prolongation: cardiac arrhythmia risk.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Clostridioides difficile colitis: severe diarrhea with abdominal pain.
  • Stevens‑Johnson syndrome: mucocutaneous blistering.
  • Hematologic abnormalities: neutropenia or thrombocytopenia.

Precautions & Warnings

Before prescribing Lekoklar, clinicians should consider several safety factors.

  • Assess liver function: avoid use in patients with severe hepatic impairment.
  • Evaluate cardiac risk: caution in individuals with known QT prolongation or electrolyte disturbances.
  • Review drug history: avoid concurrent use with strong CYP3A4 inhibitors.
  • Monitor renal function: dose adjustment may be needed in severe renal impairment.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Clarithromycin interacts with several drug classes; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): may cause toxic plasma levels.
  • Certain antiarrhythmics (e.g., amiodarone, sotalol): increase risk of QT prolongation.
  • Statins metabolized by CYP3A4 (e.g., simvastatin, lovastatin): heightened risk of myopathy.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, monitor INR.
  • Theophylline: increased serum concentrations, watch for toxicity.
  • Oral hypoglycemics (e.g., sulfonylureas): potential hypoglycemia, monitor glucose.
  • Carbamazepine: reduced clarithromycin levels, assess efficacy.
  • Digoxin: possible increased levels, monitor cardiac signs.

Frequently Asked Questions

Lekoklar, containing clarithromycin, is indicated for adult patients with community‑acquired pneumonia, acute bacterial sinusitis, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication. These uses reflect its activity against a range of Gram‑positive and some Gram‑negative bacteria.

Clarithromycin binds to the bacterial 50S ribosomal subunit, blocking the translocation step of protein synthesis. This inhibition stops the formation of new proteins, leading to a bacteriostatic effect that limits bacterial growth and allows the immune system to clear the infection.

The specific dose of Lekoklar is determined by the prescribing clinician based on the infection type, severity, patient age, weight, renal and hepatic function, and any concomitant medications. Healthcare professionals follow established guidelines to set the appropriate regimen.

Safety data for clarithromycin in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians should discuss risks and alternatives with the patient before prescribing.

To request Lekoklar, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lekoklar (clarithromycin) offers a broader spectrum against certain atypical pathogens and has a longer half‑life than erythromycin, allowing twice‑daily dosing. Compared with azithromycin, clarithromycin may have more drug‑interaction potential due to CYP3A4 inhibition, but both are effective macrolides for similar indications.

Lekoklar should be stored at ambient temperature, below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight to maintain stability throughout the shelf life.

Lekoklar is taken orally, usually with or without food as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious risks include hepatotoxicity, QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis. Patients should be monitored for signs of liver dysfunction, cardiac symptoms, and persistent diarrhea.

Lekoklar is contraindicated in patients with known hypersensitivity to clarithromycin or other macrolides, those with a history of severe QT prolongation, and individuals taking contraindicated strong CYP3A4 inhibitors. Caution is also advised for patients with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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