Product image of Lekoklar (Clarithromycin) supplied by GNH India

Lekoklar

Active Ingredient:
Clarithromycin
Origin:
EU

Lekoklar (Clarithromycin)

Clarithromycin, the active ingredient in Lekoklar, is a macrolide antibiotic presented as an oral dosage form for oral use. It treats a range of bacterial infections in adults and children when prescribed by a qualified health professional.

GNH India supplies Lekoklar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Pharmaceuticals D.D.

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Indications & Clinical Uses

Clarithromycin is used to treat infections caused by susceptible bacteria in several organ systems.

  • Community‑acquired pneumonia: eradicates the causative bacteria and improves respiratory function.
  • Acute bacterial sinusitis: reduces sinus inflammation and clears infection.
  • Acute otitis media: eliminates middle‑ear pathogens and relieves pain.
  • Skin and soft‑tissue infections: combats skin‑associated bacterial strains and promotes healing.
  • Helicobacter pylori eradication: part of combination therapy to eradicate H. pylori infection.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, inhibiting the translocation step of protein synthesis. This action prevents the elongation of peptide chains, thereby halting bacterial growth and leading to a bacteriostatic effect against susceptible organisms.

Side Effects

Clarithromycin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: increased bowel movements, sometimes watery.
  • Taste disturbance: altered or metallic taste perception.
  • Headache: mild to moderate cranial pain.

Serious or Rare Side Effects

  • Clostridioides difficile‑associated diarrhea: severe colitis requiring medical attention.
  • QT interval prolongation: potential cardiac arrhythmia risk.
  • Severe allergic reactions: including anaphylaxis, rash, or angioedema.

Precautions & Warnings

Before using clarithromycin, consider the following safety measures.

  • Renal impairment: assess kidney function and adjust therapy if needed.
  • Hepatic dysfunction: use with caution in patients with liver disease.
  • Cardiac history: monitor ECG for QT prolongation in at‑risk individuals.
  • Pregnancy: risk category unknown; evaluate benefits versus potential risks.
  • Drug interactions: review all concomitant medications for possible interactions.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Clarithromycin can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise clarithromycin levels.
  • Ergot alkaloids: risk of ergotism due to increased exposure.
  • Warfarin: enhanced anticoagulant effect, increasing bleeding risk.

Moderate Interactions (Monitor Closely)

  • Statins metabolized by CYP3A4 (e.g., simvastatin): monitor for myopathy.
  • Theophylline: possible increase in plasma concentration.
  • Carbamazepine: may reduce clarithromycin effectiveness.

Frequently Asked Questions

Lekoklar, containing clarithromycin, is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute otitis media, skin and soft‑tissue infections, and as part of combination therapy for Helicobacter pylori eradication.

Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking the translocation step required for peptide chain elongation. This halts bacterial growth, producing a bacteriostatic effect against susceptible organisms.

The dosage of Lekoklar is determined by the prescribing clinician based on the specific infection, patient age, weight, renal and hepatic function, and local treatment guidelines. Patients should follow the prescriber’s instructions exactly.

The safety of clarithromycin in pregnancy and lactation has not been definitively established. Healthcare providers weigh potential benefits against unknown risks before prescribing to pregnant or nursing individuals.

To request Lekoklar, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clarithromycin shares the macrolide class with azithromycin and erythromycin but generally offers a broader spectrum against certain atypical pathogens and higher gastric stability. Choice of agent depends on infection type, resistance patterns, patient tolerance and clinician preference.

Lekoklar should be stored at ambient temperature, below 25 °C, in its original container, protected from moisture and direct sunlight. Do not store in bathrooms or near heat sources.

Lekoklar is taken orally, usually with a full glass of water. It may be taken with or without food, but consistency with meals can help reduce gastrointestinal upset. Follow the prescriber’s dosing schedule for optimal effect.

Serious risks include Clostridioides difficile‑associated diarrhea, QT interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, and rare hepatic injury. Patients should seek immediate medical attention if they experience severe diarrhea, palpitations, rash, or signs of liver dysfunction.

Individuals with known hypersensitivity to clarithromycin or other macrolides should avoid Lekoklar. Caution is advised for patients with significant hepatic impairment, prolonged QT interval, or those taking contraindicated medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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