Lem Plus (Paracetamol)

Paracetamol acts systemically to alleviate pain and lower temperature.

• Pain: provides relief from mild to moderate pain such as headache, toothache, or musculoskeletal discomfort.
• Fever: reduces elevated body temperature associated with infections or inflammatory conditions.
• Headache: alleviates tension‑type and migraine‑associated headache pain.
• Menstrual discomfort: eases dysmenorrhea‑related cramping and pain.

• Paracetamol exerts its effect by inhibiting the synthesis of prostaglandins in the central nervous system, primarily through blockade of the cyclooxygenase (COX) pathway. This reduction in prostaglandin levels diminishes the perception of pain and lowers the hypothalamic set‑point for body temperature, resulting in analgesic and antipyretic actions without significant peripheral anti‑inflammatory activity.

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild stomach upset or queasiness.
• Rash: skin redness or mild itching.
• Elevated liver enzymes: transient increase detectable in blood tests.
• Headache: occasional worsening of head pain.
• Dizziness: brief feeling of light‑headedness.

Serious or Rare Side Effects

• Hepatotoxicity: severe liver injury, especially with overdose.
• Stevens‑Johnson syndrome: rare severe skin reaction.
• Blood disorders: thrombocytopenia or neutropenia.
• Anaphylaxis: rare life‑threatening allergic reaction.

Paracetamol should be used with attention to safety considerations.

• Liver function: assess hepatic health before prolonged use.
• Alcohol consumption: avoid excessive alcohol as it increases liver risk.
• Maximum dose: do not exceed the recommended daily total dose.
• Pregnancy and breastfeeding: consult a healthcare professional before use.
• Children: keep out of reach of children and use age‑appropriate formulations.
• Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture.

Paracetamol may interact with other medicines, requiring monitoring.

Major Interactions (Avoid)

• Warfarin: may increase anticoagulant effect and INR.
• Alcohol: combined use heightens risk of liver injury.
• Enzyme inducers (e.g., carbamazepine, phenytoin): can reduce paracetamol effectiveness.

Moderate Interactions (Monitor Closely)

• Other hepatotoxic drugs (e.g., isoniazid, methotrexate): monitor liver function.
• Antiepileptics (e.g., valproate): may alter plasma levels.
• Certain antivirals (e.g., ritonavir): may increase paracetamol exposure.