Product image of Lemesil (Nimesulide) supplied by GNH India

Lemesil

Active Ingredient:
Nimesulide
Origin:
EU

Lemesil (Nimesulide)

Nimesulide, the active ingredient in Lemesil, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats pain, fever and inflammatory conditions in adults.

GNH India supplies Lemesil as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Anfarm Hellas Sa

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Indications & Clinical Uses

Lemesil (nimesulide) is employed in the management of several painful and inflammatory conditions that involve cyclooxygenase‑2 mediated pathways.

  • Pain: provides analgesic relief in acute and chronic musculoskeletal pain.
  • Fever: reduces elevated body temperature associated with infectious or inflammatory processes.
  • Osteoarthritis: alleviates joint pain and improves functional mobility.
  • Dysmenorrhea: eases menstrual cramps and associated discomfort.

How It Works

  • Nimesulide selectively inhibits the cyclooxygenase‑2 (COX‑2) enzyme, decreasing the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis diminishes inflammation, lowers pain signaling, and produces antipyretic effects while sparing COX‑1 activity, which helps maintain gastric mucosal protection.

Side Effects

Adverse reactions may occur with any NSAID and should be monitored.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or mild abdominal pain.
  • Headache: transient tension‑type headache.
  • Dizziness: occasional light‑headedness.
  • Skin rash: mild erythema or pruritus.
  • Elevated liver enzymes: transient increase in transaminases.

Serious or Rare Side Effects

  • Hepatotoxicity: severe liver injury, potentially leading to jaundice.
  • Severe gastrointestinal bleeding or ulceration.
  • Renal impairment: acute kidney injury, especially in volume‑depleted patients.
  • Hypersensitivity reactions: anaphylaxis or Stevens‑Johnson syndrome.
  • Cardiovascular events: increased risk of thrombotic events in susceptible individuals.

Precautions & Warnings

Before prescribing Lemesil, clinicians should consider patient‑specific risk factors and monitor appropriately.

  • Hypersensitivity: avoid in patients with known allergy to nimesulide or other NSAIDs.
  • Hepatic function: use caution and monitor liver enzymes in patients with liver disease.
  • Renal function: assess kidney status and adjust use in renal impairment.
  • Elderly patients: limit duration due to higher risk of gastrointestinal complications.
  • Concomitant medications: review for potential drug‑drug interactions.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Nimesulide may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Other NSAIDs or COX‑2 inhibitors: increased risk of gastrointestinal bleeding.
  • Anticoagulants (e.g., warfarin, DOACs): heightened bleeding tendency.
  • Hepatotoxic agents (e.g., isoniazid, methotrexate): potential additive liver injury.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, diuretics): possible reduction in blood‑pressure control.
  • Lithium: nimesulide may raise serum lithium concentrations.
  • Corticosteroids: combined use can amplify ulcerogenic risk.

Frequently Asked Questions

Lemesil contains nimesulide, an NSAID indicated for the relief of mild to moderate pain, reduction of fever, and management of inflammatory conditions such as osteoarthritis and dysmenorrhea. It is prescribed for adult patients when a COX‑2 selective anti‑inflammatory effect is desired.

Nimesulide works by selectively blocking the cyclooxygenase‑2 (COX‑2) enzyme, which reduces the production of prostaglandins that mediate inflammation, pain, and fever. By sparing COX‑1, it aims to maintain gastric mucosal protection while providing anti‑inflammatory and analgesic benefits.

The appropriate dose of Lemesil is determined by the prescribing healthcare professional based on the individual’s condition, severity, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for nimesulide in pregnancy and lactation are limited. Generally, it is avoided during the first trimester and throughout pregnancy unless the potential benefit outweighs the risk. Breastfeeding mothers should consult their physician, as the drug may be excreted in milk.

To order Lemesil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lemesil (nimesulide) offers COX‑2 selectivity, which may reduce the risk of gastrointestinal irritation compared with non‑selective NSAIDs like ibuprofen. However, it carries a distinct hepatic safety profile, requiring liver function monitoring, whereas some alternatives may have different cardiovascular or renal risk considerations.

Lemesil should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Lemesil is taken orally, usually with a full glass of water. It can be taken with or without food, but patients who experience stomach upset may benefit from taking it with meals. The exact administration schedule is set by the prescriber.

The most serious risks include severe liver injury, gastrointestinal bleeding or ulceration, and rare but life‑threatening hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be educated to report any signs of jaundice, abdominal pain, or unusual skin reactions promptly.

Lemesil should be avoided in individuals with known hypersensitivity to nimesulide or other NSAIDs, those with active peptic ulcer disease, severe hepatic impairment, or uncontrolled heart failure. Caution is also advised for patients on anticoagulants, other COX‑2 inhibitors, or with significant renal dysfunction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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