Product image of Lemoxol (Ceftazidime) supplied by GNH India

Lemoxol

Active Ingredient:
Ceftazidime
Origin:
EU

Lemoxol (Ceftazidime)

Ceftazidime, the active ingredient in Lemoxol, is a third‑generation cephalosporin presented as a parenteral solution for intramuscular and intravenous use. It treats severe Gram‑negative infections, including those caused by Pseudomonas aeruginosa, in hospitalized patients.

GNH India supplies Lemoxol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

Ceftazidime is indicated for infections caused by susceptible Gram‑negative bacteria, particularly in hospital‑acquired settings.

  • Severe Gram‑negative infections: provides bactericidal activity to eradicate the pathogen.
  • Pseudomonas aeruginosa infections: effective against this resistant organism in systemic disease.
  • Nosocomial pneumonia: treats ventilator‑associated and other hospital‑acquired pneumonias.
  • Complicated urinary tract infections: clears infection when oral agents are insufficient.
  • Intra‑abdominal infections: used for peritonitis and related intra‑abdominal sepsis.

How It Works

  • Ceftazidime binds to penicillin‑binding proteins on the bacterial cell wall, inhibiting the final transpeptidation step of peptidoglycan synthesis. This disruption weakens the cell wall, leading to osmotic instability and bacterial lysis, particularly in Gram‑negative organisms that rely on robust cell‑wall integrity.

Side Effects

Ceftazidime may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Diarrhea: mild to moderate loose stools.
  • Nausea: occasional feeling of queasiness.
  • Rash: transient skin erythema.
  • Injection site pain: discomfort at the administration site.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Stevens‑Johnson syndrome: rare but serious skin and mucous membrane disorder.
  • Clostridioides difficile‑associated colitis: severe intestinal inflammation.
  • Seizures: neurologic events, especially in patients with renal impairment.

Precautions & Warnings

Before using Lemoxol, consider the following safety measures.

  • Renal function: assess kidney function and adjust dose in impairment.
  • Hepatic function: monitor liver enzymes during prolonged therapy.
  • Allergy history: avoid in patients with known cephalosporin or penicillin hypersensitivity.
  • Superinfection risk: watch for fungal or secondary bacterial overgrowth.
  • Pregnancy: category B; use only when benefit outweighs potential risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Ceftazidime can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Aminoglycosides: combined nephrotoxicity may increase renal damage.
  • Probenecid: reduces renal clearance, raising ceftazidime plasma levels.
  • Lithium: may increase lithium concentrations, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: monitor renal function and electrolytes.
  • NSAIDs: may enhance renal adverse effects.
  • Oral contraceptives: possible reduction in contraceptive effectiveness.

Frequently Asked Questions

Lemoxol, containing ceftazidime, is used to treat severe Gram‑negative bacterial infections such as Pseudomonas aeruginosa infections, hospital‑acquired pneumonia, complicated urinary tract infections, and intra‑abdominal sepsis. It is typically reserved for patients who need intravenous or intramuscular therapy in a hospital setting.

Ceftazidime interferes with bacterial cell‑wall synthesis by binding to penicillin‑binding proteins. This blocks the cross‑linking of peptidoglycan strands, weakening the wall and causing the bacterium to burst, which results in a rapid bactericidal effect against susceptible Gram‑negative organisms.

The dosage of Lemoxol is determined by the prescribing clinician based on the type and severity of infection, patient weight, renal function, and other clinical factors. Healthcare providers set the exact amount, frequency, and duration of therapy.

Lemoxol is classified as pregnancy category B, indicating that animal studies have not shown risk to the fetus and there are no well‑controlled human studies. It should be used only if the potential benefit justifies any possible risk. Limited data are available for breastfeeding, so a risk‑benefit assessment is required.

To order Lemoxol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Lemoxol (ceftazidime) is a third‑generation cephalosporin with enhanced activity against Pseudomonas aeruginosa and other resistant Gram‑negative bacteria, unlike many earlier‑generation cephalosporins. Its broad spectrum and stability against beta‑lactamases make it a preferred option for serious hospital‑acquired infections, though it may have a higher risk of certain adverse effects compared with some newer agents.

Lemoxol should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken vigorously. Once reconstituted, the solution should be used within the time frame specified in the product labeling and kept under the same temperature conditions until administration.

Lemoxol is supplied as a sterile injectable solution for intramuscular or intravenous administration. The route, infusion rate, and dilution are determined by the prescribing clinician based on the infection being treated and patient-specific factors such as renal function.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, Clostridioides difficile‑associated colitis, seizures (especially in patients with renal impairment), and significant renal toxicity when combined with other nephrotoxic drugs.

Lemoxol should be avoided in patients with a documented hypersensitivity to ceftazidime, other cephalosporins, or penicillins. Caution is also advised for individuals with severe renal impairment, a history of severe allergic reactions, or those receiving concurrent nephrotoxic medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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