Lemsip Max (Phenylephrine Hydrochloride, Guaifenesin, Paracetamol)

Lemsip Max, a combination analgesic, decongestant and expectorant, is used to alleviate symptoms associated with upper respiratory infections and influenza.

• Cold and flu symptoms: alleviates overall discomfort, fever and body aches.
• Nasal congestion: reduces swelling of nasal mucosa to improve airflow.
• Chest congestion: thins mucus to facilitate expectoration.
• Fever: lowers elevated body temperature.
• Headache: provides analgesic relief.
• Body aches: eases muscular pain associated with viral illness.

• Phenylephrine acts as an alpha‑adrenergic agonist causing vasoconstriction of nasal mucosa, which reduces congestion. Guaifenesin increases bronchial mucus secretion and lowers its viscosity, aiding expectoration. Paracetamol inhibits central prostaglandin synthesis, delivering analgesic and antipyretic effects. The combined actions address multiple cold and flu symptoms through vascular, mucosal and central pathways.

Common Side Effects

• Nausea: mild stomach upset may occur.
• Dizziness: transient light‑headedness reported.
• Dry mouth: reduced salivation is typical.
• Mild rash: occasional skin irritation.

Serious or Rare Side Effects

• Allergic reactions: including anaphylaxis, hives or swelling.
• Severe skin reactions: such as Stevens‑Johnson syndrome.
• Elevated blood pressure or cardiac arrhythmia: due to phenylephrine’s vasoconstrictive action.

Before using Lemsip Max, consider the following precautions:

• Do not exceed recommended dose: follow prescriber or label instructions.
• Avoid concurrent use with other paracetamol‑containing products: risk of overdose.
• Caution in patients with hypertension: phenylephrine may raise blood pressure.
• Avoid in severe liver disease: paracetamol metabolism is impaired.
• Pregnancy: consult a healthcare professional before use.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Lemsip Max may interact with other medicines as follows:

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
• Other sympathomimetic decongestants: additive vasoconstriction.
• Anticoagulants such as warfarin: increased bleeding risk with paracetamol.

Moderate Interactions (Monitor Closely)

• Antihypertensive agents: phenylephrine may diminish their effect.
• Alcohol: enhances hepatotoxic potential of paracetamol.
• Selective serotonin reuptake inhibitors (SSRIs): monitor for serotonin syndrome when combined with MAOIs.