Lemsip Max Day & Night Cold & Flu Relief (Phenylephrine Hydrochloride, Paracetamol | Phenylephrine Hydrochloride, Paracetamol, Caffeine)

Lemsip Max Day & Night combines paracetamol, phenylephrine hydrochloride, and caffeine to address symptoms of the common cold and influenza.

• Headache: provides analgesic relief, reducing pain intensity.
• Fever: lowers elevated body temperature through antipyretic action.
• Nasal congestion: decongests nasal passages, improving airflow.
• Sore throat: alleviates throat discomfort associated with viral upper respiratory infection.
• General cold and flu symptoms: eases multiple concurrent symptoms such as body aches and fatigue.

• Paracetamol acts centrally by inhibiting cyclooxygenase enzymes, reducing prostaglandin synthesis and thereby decreasing pain and fever. Phenylephrine hydrochloride is an α1‑adrenergic receptor agonist that causes vasoconstriction of nasal mucosal blood vessels, relieving congestion. Caffeine stimulates the central nervous system and can enhance the analgesic effect of paracetamol, contributing to increased alertness during daytime use.

Adverse reactions reported with Lemsip Max Day & Night are generally related to its individual components.

Common Side Effects

• Nausea: mild stomach upset.
• Dizziness: transient light‑headedness.
• Insomnia: difficulty falling asleep, especially with caffeine.
• Headache: paradoxical headache in some users.
• Gastrointestinal discomfort: mild abdominal pain or indigestion.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Liver injury: elevated liver enzymes or hepatitis with excessive paracetamol intake.
• Severe hypertension: marked increase in blood pressure due to phenylephrine.

Before using Lemsip Max Day & Night, consider the following precautions to ensure safe and effective use.

• Dosage limit: do not exceed the maximum daily amount of paracetamol to avoid liver toxicity.
• Existing medical conditions: consult a healthcare professional if you have liver disease, hypertension, or heart disease.
• Drug interactions: avoid concurrent use with other paracetamol‑containing products or monoamine oxidase inhibitors.
• Pregnancy and breastfeeding: discuss use with a physician, as safety data are limited.
• Age restrictions: not recommended for children under the specified age without medical advice.
• Store at ambient temperature: keep below 25°C, retain in original packaging, and protect from moisture.

Lemsip Max Day & Night may interact with other medicines; awareness of major and moderate interactions helps prevent adverse events.

Major Interactions (Avoid)

• Other paracetamol products: risk of cumulative hepatotoxicity.
• Monoamine oxidase inhibitors (MAOIs): can cause hypertensive crisis with phenylephrine.
• Certain antidepressants (e.g., SSRIs): may increase risk of serotonin syndrome when combined with other serotonergic agents.

Moderate Interactions (Monitor Closely)

• Anticoagulants (e.g., warfarin): paracetamol may enhance anticoagulant effect.
• Antihypertensive drugs: phenylephrine may reduce their efficacy.
• Caffeine‑containing beverages or medications: may increase stimulant effects and cause insomnia.