Product image of Lenalidomid Avansor (Lenalidomide) supplied by GNH India

Lenalidomid Avansor

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Avansor (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Avansor, is an immunomodulatory imide drug (IMiD) presented as an oral tablet for oral use. It is indicated for the treatment of certain hematologic malignancies, including multiple myeloma, mantle cell lymphoma, and myelodysplastic syndromes, and is prescribed for adult patients under specialist supervision.

GNH India supplies Lenalidomid Avansor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Avansor Pharma Oy

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Indications & Clinical Uses

Lenalidomid Avansor (lenalidomide) is used in the management of hematologic cancers that involve abnormal plasma or lymphoid cells.

  • Multiple Myeloma: improves progression‑free survival and overall response rates in adult patients.
  • Mantle Cell Lymphoma: contributes to disease control in relapsed or refractory cases.
  • Myelodysplastic Syndromes: reduces transfusion dependence and delays transformation to acute leukemia.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4^CRBN E3 ubiquitin ligase complex, altering its substrate specificity. This leads to ubiquitination and proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), resulting in anti‑angiogenic, immunomodulatory, and direct anti‑tumor effects, including enhanced natural killer cell activity and inhibition of tumor cell proliferation.

Side Effects

Lenalidomid Avansor may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may require fluid replacement.
  • Nausea: feeling of sickness often accompanied by vomiting.
  • Rash: skin irritation or redness.
  • Constipation: difficulty passing stools.
  • Peripheral neuropathy: tingling or numbness in extremities.

Serious or Rare Side Effects

  • Thromboembolic events: blood clots such as deep‑vein thrombosis or pulmonary embolism.
  • Severe neutropenia: markedly reduced neutrophil count increasing infection risk.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Secondary malignancies: emergence of new cancers, particularly skin cancers.

Precautions & Warnings

When prescribing Lenalidomid Avansor, clinicians should consider several safety measures and monitoring requirements.

  • Pregnancy contraindication: drug is classified as Category X and must not be used during pregnancy.
  • Thrombosis risk: assess patient history and consider prophylactic anticoagulation.
  • Renal function: adjust monitoring in patients with impaired kidney function.
  • Hematologic monitoring: perform regular complete blood counts to detect cytopenias.
  • Teratogenicity prevention: ensure effective contraception for both male and female patients of reproductive potential.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct light.

Avoid Interactions

Lenalidomid Avansor can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce lenalidomide exposure.
  • Anticoagulants (warfarin, direct oral anticoagulants): increase risk of bleeding.
  • Immunosuppressants (e.g., cyclosporine): may enhance hematologic toxicity.

Moderate Interactions (Monitor Closely)

  • P-glycoprotein inhibitors (e.g., verapamil): may increase plasma levels.
  • Vaccines containing live attenuated viruses: risk of infection due to immunomodulation.
  • NSAIDs and aspirin: may exacerbate thrombocytopenia.

Frequently Asked Questions

Lenalidomid Avansor contains lenalidomide and is prescribed for adult patients with multiple myeloma, mantle cell lymphoma, and myelodysplastic syndromes. These are hematologic cancers where the drug helps control disease progression, improve response rates, and reduce the need for blood transfusions.

Lenalidomide binds to cereblon, a component of the CRL4^CRBN E3 ubiquitin ligase complex, changing its activity. This triggers the degradation of transcription factors Ikaros and Aiolos, leading to anti‑angiogenic, immunomodulatory, and direct anti‑tumor effects, such as enhanced natural‑killer cell activity and inhibition of malignant cell growth.

The specific dose of Lenalidomid Avansor is determined by the prescribing physician based on the patient’s diagnosis, disease stage, renal function, and other clinical factors. Only a qualified healthcare professional should set the dosing regimen.

Lenalidomid Avansor is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. Women of child‑bearing potential must use effective contraception, and breastfeeding is not recommended while taking the medication.

To request Lenalidomid Avansor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lenalidomid Avansor belongs to the immunomodulatory imide drug class, offering a distinct mechanism of action compared with proteasome inhibitors or monoclonal antibodies. It provides oral administration, which can be more convenient, and has demonstrated efficacy in improving progression‑free survival, especially when used in combination regimens.

Lenalidomid Avansor should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct light to maintain stability throughout its shelf life.

Lenalidomid Avansor is taken orally, usually as a tablet, with or without food as directed by the prescriber. Patients should follow the exact dosing schedule provided by their healthcare professional and not alter the regimen without medical advice.

The most serious risks include thromboembolic events (blood clots), severe neutropenia leading to infection, hepatotoxicity, and the potential for secondary malignancies. Patients should be monitored regularly for signs of these conditions, and any concerning symptoms should be reported promptly.

Lenalidomid Avansor should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with uncontrolled severe infections. It is also contraindicated in patients who cannot adhere to strict contraception requirements.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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