Product image of Lenalidomid Devatis (Lenalidomide) supplied by GNH India

Lenalidomid Devatis

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Devatis (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Devatis, is an immunomodulatory drug (IMiD) presented as an oral tablet for oral use. It is employed in the treatment of multiple myeloma and myelodysplastic syndromes, targeting malignant plasma cells and abnormal bone marrow clones in adult patients. It is indicated for adult patients with relapsed or refractory disease and is administered under specialist supervision.

GNH India supplies Lenalidomid Devatis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company ensures consistent quality and regulatory compliance for oncology therapeutics.

Manufacturer / TM Owner

Devatis Gmbh

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Indications & Clinical Uses

Lenalidomide is an immunomodulatory agent used in hematologic malignancies and bone marrow disorders.

  • Multiple myeloma: improves progression‑free survival and reduces disease burden.
  • Relapsed/refractory multiple myeloma: provides a therapeutic option after prior therapies.
  • Myelodysplastic syndromes: reduces transfusion dependence and may improve blood counts.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4 E3 ubiquitin ligase complex, altering substrate specificity and leading to degradation of transcription factors Ikaros and Aiolos. This results in modulation of cytokine production, inhibition of angiogenesis, and induction of apoptosis in malignant plasma cells and dysplastic hematopoietic clones.

Side Effects

Adverse reactions may occur with lenalidomide therapy.

Common Side Effects

  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may require supportive care.
  • Rash: mild skin eruptions.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Severe neutropenia: profound drop in neutrophils requiring medical intervention.
  • Secondary primary malignancies: emergence of new cancers.
  • Hepatotoxicity: liver enzyme elevations indicating liver stress.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Monitor blood counts: perform regular CBC to detect cytopenias.
  • Assess thrombotic risk: evaluate history of clotting disorders and consider prophylaxis.
  • Avoid pregnancy: contraindicated; enforce effective contraception.
  • Adjust for renal impairment: dose may need modification in reduced kidney function.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.
  • Keep out of reach of children: ensure secure storage to prevent accidental ingestion.

Avoid Interactions

Lenalidomide may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase exposure.
  • Thalidomide: combined use heightens teratogenic risk.
  • Live vaccines: immunosuppression can reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce drug levels.
  • Anticoagulants (e.g., warfarin): monitor coagulation parameters due to thrombosis risk.
  • NSAIDs: may increase risk of renal impairment when combined.

Frequently Asked Questions

Lenalidomid Devatis contains lenalidomide, which is prescribed for adult patients with multiple myeloma and for those with myelodysplastic syndromes. In both conditions it helps control disease progression, reduces the need for blood transfusions, and may improve overall survival when used under specialist supervision.

Lenalidomide binds to cereblon, a component of the CRL4 E3 ubiquitin ligase complex, altering the degradation of specific transcription factors. This leads to reduced cytokine production, inhibition of new blood‑vessel formation, and programmed cell death of malignant plasma cells and abnormal bone‑marrow clones.

The dosage of Lenalidomid Devatis is individualized by the treating physician based on the specific indication, disease stage, renal function, and patient tolerance. The prescriber determines the exact amount and schedule, and patients should follow the written prescription without deviation.

Lenalidomid Devatis is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as the drug may be excreted in milk and affect the infant. Effective contraception is required for both men and women receiving the medication.

To request Lenalidomid Devatis, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and the necessary import documentation.

Both lenalidomide and thalidomide belong to the immunomodulatory drug class, but lenalidomide is generally more potent, has a different safety profile, and is associated with lower rates of peripheral neuropathy. Lenalidomide also offers stronger anti‑angiogenic activity and is the preferred option for many patients with multiple myeloma and myelodysplastic syndromes.

Store Lenalidomid Devatis at ambient temperature, preferably below 25 °C, in the original container to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the packaging.

Lenalidomid Devatis is supplied as oral tablets that should be swallowed whole with a glass of water. The medication is taken according to the schedule prescribed by the healthcare professional, which may include daily dosing or specific cycles depending on the treatment plan.

The most serious risks include severe neutropenia, venous thromboembolism, secondary primary malignancies, and serious skin reactions such as Stevens‑Johnson syndrome. Patients should report signs of infection, unexplained bruising, swelling or pain in the legs, and any rash that spreads or blisters promptly to their clinician.

Lenalidomid Devatis should not be used by individuals who are pregnant, planning to become pregnant, or who are not using effective contraception. It is also contraindicated in patients with known hypersensitivity to lenalidomide or any component of the formulation, and caution is advised in those with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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