Product image of Lenalidomid Ethypharm (Lenalidomide) supplied by GNH India

Lenalidomid Ethypharm

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Ethypharm (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Ethypharm, is an immunomodulatory drug (IMiD) presented as an oral tablet for oral use. It is used to treat certain blood cancers such as multiple myeloma, mantle cell lymphoma, and myelodysplastic syndromes in adult patients and is approved for use in the European Union.

GNH India supplies Lenalidomid Ethypharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Grindeks

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Indications & Clinical Uses

Lenalidomide acts on malignant plasma cells and related pathways in hematologic malignancies.

  • Multiple Myeloma: improves progression‑free survival and overall response rates in patients with relapsed or refractory disease.
  • Mantle Cell Lymphoma: used in combination regimens to achieve disease control in adult patients.
  • Myelodysplastic Syndromes: indicated for patients with deletion 5q cytogenetic abnormality to reduce transfusion dependence.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering its substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, resulting in anti‑angiogenic, immunomodulatory, and anti‑proliferative effects that suppress malignant cell growth.

Side Effects

Lenalidomide may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Thrombocytopenia: low platelet levels that may cause bleeding.
  • Anemia: decreased red blood cell count leading to fatigue.
  • Fatigue: general feeling of tiredness.
  • Diarrhea: loose stools or increased bowel movements.
  • Rash: mild skin irritation or redness.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Secondary primary malignancies: emergence of new cancers.
  • Hepatic failure: significant liver enzyme elevation or dysfunction.
  • Interstitial lung disease: inflammation of lung tissue causing breathing difficulties.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient-specific risk factors and monitor for adverse events.

  • Monitor blood counts: perform regular CBC to detect neutropenia, thrombocytopenia, or anemia.
  • Assess thrombotic risk: consider prophylactic anticoagulation in high‑risk patients.
  • Avoid use in pregnancy: teratogenic potential requires effective contraception.
  • Evaluate renal and hepatic function: dose adjustments may be needed for impairment.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lenalidomide may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin): may markedly reduce lenalidomide exposure.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Live vaccines: heightened risk of infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (e.g., aspirin): additive bleeding tendency.
  • CYP3A4 inhibitors (e.g., ketoconazole): may increase lenalidomide plasma levels.
  • Immunosuppressants (e.g., cyclosporine): potential for enhanced toxicity.

Frequently Asked Questions

Lenalidomid Ethypharm contains lenalidomide and is indicated for the treatment of adult patients with multiple myeloma, mantle cell lymphoma, and myelodysplastic syndromes that have a deletion 5q cytogenetic abnormality. It is prescribed as part of a broader therapeutic regimen by a qualified healthcare professional.

Lenalidomide binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase complex. This binding changes the complex’s activity, leading to the degradation of transcription factors Ikaros and Aiolos. The resulting anti‑angiogenic, immunomodulatory, and anti‑proliferative actions help suppress the growth of malignant blood cells.

The specific dose of Lenalidomid Ethypharm is determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal and hepatic function, and other individual factors. Only a qualified healthcare professional can set the appropriate dosing regimen.

Lenalidomid Ethypharm is classified as potentially teratogenic, and its safety in pregnancy has not been established. Women of childbearing potential should use effective contraception during treatment and for a defined period after the last dose. Breastfeeding is not recommended while taking this medication.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details and any necessary import documentation.

Lenalidomide belongs to the immunomodulatory drug class, offering a distinct mechanism compared with proteasome inhibitors or monoclonal antibodies. It provides oral administration, which can be advantageous for outpatient care, and has demonstrated efficacy in improving progression‑free survival when used alone or in combination with other agents.

Lenalidomid Ethypharm should be stored at room temperature, below 25 °C, in its original packaging. The container should be kept closed to protect the tablets from moisture and light, ensuring the product maintains its stability throughout its shelf life.

The medication is taken orally, usually with or without food, as directed by the prescribing physician. Patients should swallow the tablet whole with a glass of water and follow any specific timing instructions provided by their healthcare provider.

Serious risks include venous thromboembolism, severe cutaneous reactions such as Stevens‑Johnson syndrome, secondary primary malignancies, hepatic failure, and interstitial lung disease. Patients should be monitored closely for signs of these events, and any concerning symptoms should prompt immediate medical evaluation.

Lenalidomid Ethypharm is contraindicated in patients who are pregnant, have known hypersensitivity to lenalidomide or any excipients, or have uncontrolled severe infections. Caution is also advised for individuals with significant renal or hepatic impairment, and those with a high baseline risk of thromboembolic events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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