Product image of Lenalidomid Olainfarm (Lenalidomide) supplied by GNH India

Lenalidomid Olainfarm

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Olainfarm (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Olainfarm, is an immunomodulatory imide drug (IMiD) presented as a tablet for oral use. It is indicated for the treatment of multiple myeloma, myelodysplastic syndromes with del(5q), and mantle cell lymphoma in adult patients.

GNH India supplies Lenalidomid Olainfarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, with distribution across EU and other regulated markets. The product complies with EU GMP requirements and is manufactured under strict quality controls.

Manufacturer / TM Owner

Jsc Olainfarm

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Indications & Clinical Uses

Lenalidomide is employed in the management of several hematologic malignancies and related bone‑marrow disorders, where it modifies disease biology and improves clinical outcomes.

  • Multiple myeloma: improves progression‑free survival and overall response in adult patients.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and can induce cytogenetic remission.
  • Mantle cell lymphoma: used in combination regimens to achieve disease control in relapsed or refractory cases.
  • Transfusion‑dependent anemia in del(5q) MDS: helps achieve transfusion independence and improves blood counts.
  • Relapsed or refractory disease: provides an additional therapeutic option when standard regimens have failed.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4^CRBN E3 ubiquitin ligase complex, altering substrate specificity and leading to the degradation of transcription factors Ikaros and Aiolos. This results in anti‑angiogenic activity, modulation of immune cell function, and direct anti‑tumor effects through inhibition of proliferation and induction of apoptosis in malignant cells.

Side Effects

Common Side Effects

  • Fatigue.
  • Neutropenia.
  • Constipation.

Serious or Rare Side Effects

  • Venous thromboembolism.
  • Severe liver enzyme elevation.
  • Secondary primary malignancies.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Pregnancy: contraindicated (Category X) – avoid use in pregnant women.
  • Thrombosis risk: assess and manage risk factors prior to treatment.
  • Renal impairment: monitor renal function and adjust follow‑up as needed.
  • Hematologic monitoring: perform regular complete blood counts to detect cytopenias.
  • Drug interactions: avoid concomitant use with strong CYP inducers without medical supervision.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Lenalidomid Olainfarm may interact with several medicines. Review the following:

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may reduce efficacy.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Live vaccines: risk of infection due to immunomodulation.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (e.g., aspirin): may increase bleeding risk.
  • Other immunomodulatory agents (e.g., thalidomide): additive toxicity.
  • Hepatotoxic drugs (e.g., azole antifungals): may increase liver toxicity.

Frequently Asked Questions

Lenalidomid Olainfarm contains lenalidomide and is prescribed for adult patients with multiple myeloma, myelodysplastic syndromes that have a del(5q) chromosomal abnormality, and mantle cell lymphoma. These are hematologic cancers where the drug helps control disease progression and improve blood parameters.

Lenalidomide binds to cereblon, a component of the CRL4^CRBN E3 ubiquitin ligase complex. This binding changes the complex’s substrate specificity, leading to degradation of transcription factors that promote tumor growth. The result is reduced angiogenesis, enhanced immune response against cancer cells, and direct anti‑tumor activity.

The dosage of Lenalidomid Olainfarm is determined by the prescribing physician based on the specific indication, disease stage, patient weight, renal function, and other clinical factors. Patients should follow the exact dosing regimen provided by their healthcare professional and not adjust the dose on their own.

Lenalidomid Olainfarm is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. Women of child‑bearing potential must use effective contraception. The safety of the drug during breastfeeding has not been established, so nursing mothers should avoid its use.

To request Lenalidomid Olainfarm, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lenalidomid Olainfarm (lenalidomide) belongs to the immunomodulatory imide drug class, offering a distinct mechanism compared with proteasome inhibitors or monoclonal antibodies. It provides oral administration, anti‑angiogenic and immune‑enhancing effects, and is often used in combination regimens. Choice of therapy depends on disease characteristics, prior treatments, and patient tolerance.

Lenalidomid Olainfarm tablets should be stored at ambient temperature below 25 °C. Keep them in the original packaging, protect from moisture and direct light, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

The medication is supplied as oral tablets. Patients swallow the tablet whole with water, usually once daily or as directed by their physician. It can be taken with or without food, but consistency with meals may help reduce gastrointestinal discomfort.

Serious risks include venous thromboembolism, severe neutropenia or thrombocytopenia that can lead to infection or bleeding, liver toxicity, and the potential for secondary primary malignancies. Patients should be monitored regularly for blood counts, liver function, and signs of clotting events.

Lenalidomid Olainfarm should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with uncontrolled active infections or severe hepatic impairment without close supervision. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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