Product image of Lenalidomid Pharmascience (Lenalidomide) supplied by GNH India

Lenalidomid Pharmascience

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Pharmascience (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Pharmascience, is an immunomodulatory drug presented as a tablet for oral use. It treats multiple myeloma and myelodysplastic syndromes in adult patients.

GNH India supplies Lenalidomid Pharmascience as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Pharmascience International Ltd

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Indications & Clinical Uses

  • Lenalidomide is employed in hematologic malignancies and related bone‑marrow disorders.
  • Multiple myeloma: improves disease control and prolongs survival in relapsed or refractory patients.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and improves blood counts.
  • Mantle cell lymphoma (in approved regions): contributes to response rates when used in combination regimens.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, resulting in modulation of cytokine production, enhanced immune‑mediated tumor cell killing, and inhibition of angiogenesis.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Thrombocytopenia: lowered platelet levels that may cause bleeding.
  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may lead to dehydration.
  • Rash: mild skin eruptions.
  • Constipation: difficulty passing stools.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Secondary primary malignancies: emergence of new cancers.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic failure: significant liver enzyme elevation and dysfunction.
  • Tumor lysis syndrome: rapid tumor cell breakdown causing metabolic disturbances.
  • Interstitial lung disease: inflammation of lung tissue leading to breathing difficulties.

Precautions & Warnings

  • When prescribing Lenalidomid Pharmascience, clinicians should observe several precautionary measures.
  • Monitor blood counts: perform regular CBC to detect neutropenia or thrombocytopenia.
  • Assess thrombotic risk: evaluate need for prophylactic anticoagulation.
  • Avoid use in pregnancy: drug is contraindicated due to teratogenicity.
  • Adjust for renal impairment: dose may need modification in reduced kidney function.
  • Counsel on contraception: effective birth control required during and after treatment.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lenalidomid Pharmascience can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly lower lenalidomide exposure.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding when combined.
  • Live vaccines: heightened risk of infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may raise plasma levels modestly.
  • NSAIDs (e.g., ibuprofen): can exacerbate thrombocytopenia.
  • Hormonal contraceptives: possible reduced effectiveness.
  • Other myelosuppressive agents: additive bone‑marrow toxicity.
  • Digoxin: slight increase in serum concentration.

Frequently Asked Questions

Lenalidomid Pharmascience contains lenalidomide, an immunomodulatory agent indicated for the treatment of adult patients with multiple myeloma and for myelodysplastic syndromes that have a del(5q) chromosomal abnormality. It is used to control disease progression and improve blood cell counts in these hematologic conditions.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, altering its substrate specificity. This triggers the ubiquitination and degradation of transcription factors Ikaros and Aiolos, leading to reduced tumor‑cell proliferation, enhanced immune‑mediated cytotoxicity, and inhibition of new blood‑vessel formation that supports cancer growth.

The dose of Lenalidomid Pharmascience is individualized by the prescribing physician based on the specific indication, disease stage, renal function, and patient tolerance. The prescriber determines the appropriate strength, frequency, and duration of therapy according to current clinical guidelines and patient needs.

Lenalidomid Pharmascience is classified as Pregnancy Category X because it is known to cause fetal harm and is contraindicated during pregnancy. Women of child‑bearing potential must use effective contraception during treatment and for a defined period after the last dose. The product is also not recommended for breastfeeding mothers as it may be excreted in milk.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

The primary alternative to lenalidomide is thalidomide, another immunomodulatory drug. Lenalidomide generally offers a more favorable safety profile, with lower rates of peripheral neuropathy, and it provides stronger anti‑angiogenic and immune‑stimulating effects. Both agents share teratogenic risk, but lenalidomide is often preferred for patients who cannot tolerate thalidomide’s neurotoxic side effects.

Lenalidomid Pharmascience tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in bathrooms or other humid environments.

The medication is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing relative to meals. Swallow the tablet whole; do not crush, split, or chew unless specifically directed by a healthcare professional.

Serious risks include venous thromboembolism (blood clots), secondary primary malignancies, severe skin reactions such as Stevens‑Johnson syndrome, hepatic failure, tumor lysis syndrome, and interstitial lung disease. Patients should promptly report symptoms like unexplained swelling, severe rash, jaundice, sudden shortness of breath, or persistent fever to their healthcare provider.

Lenalidomid Pharmascience should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or any excipients, patients with severe renal impairment without dose adjustment, and those who cannot adhere to the required contraception program. It is also contraindicated in patients with active, uncontrolled infections where immune suppression could worsen the condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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