Product image of Lenalidomid Stada (Lenalidomide) supplied by GNH India

Lenalidomid Stada

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Stada (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Stada, is an immunomodulatory agent presented as an oral tablet for use in adult patients. It is employed in the management of multiple myeloma and myelodysplastic syndromes with deletion 5q, providing anti‑angiogenic and immune‑modulating effects.

GNH India supplies Lenalidomid Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The product conforms to EU regulatory requirements and is distributed under controlled conditions to ensure product integrity through a network of certified logistics partners.

Manufacturer / TM Owner

Stada Arzneimittel Ges.M.B.H

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Indications & Clinical Uses

Lenalidomide is used in hematologic malignancies and related bone‑marrow disorders.

  • Multiple myeloma: used in combination regimens to improve disease control, delay progression, and extend overall survival in eligible patients.
  • Myelodysplastic syndromes with del(5q): administered to reduce red‑cell transfusion requirements and to increase hemoglobin levels, offering a disease‑modifying effect.
  • Relapsed or refractory multiple myeloma: provides an additional line of therapy for patients whose disease has progressed after prior treatments.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering its activity. This triggers selective degradation of transcription factors, leading to anti‑angiogenic effects, modulation of immune cell function, and direct anti‑tumor activity against malignant plasma cells and dysplastic marrow clones.

Side Effects

Lenalidomide may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Neutropenia
  • Thrombocytopenia
  • Anemia
  • Fatigue
  • Diarrhea

Serious or Rare Side Effects

  • Venous thromboembolism
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Secondary primary malignancies

Precautions & Warnings

Before initiating lenalidomide, several precautionary measures should be observed to ensure patient safety.

  • Blood count monitoring: Regular complete blood count monitoring is required to detect cytopenias early.
  • Thromboembolic risk assessment: Assess for risk factors of thrombosis and consider prophylactic anticoagulation when appropriate.
  • Pregnancy prevention: Lenalidomide is teratogenic; effective contraception must be used by both male and female patients of reproductive potential.
  • Renal function adjustment: Dose adjustment may be needed in patients with impaired renal function.
  • Drug interaction review: Review concomitant medications for potential interactions, especially strong CYP3A4 inducers.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce lenalidomide exposure.
  • Concurrent use with other immunomodulatory agents: increases risk of severe cytopenias.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin, DOACs): may increase bleeding risk; monitor coagulation parameters.
  • P‑glycoprotein inhibitors (e.g., cyclosporine): may increase plasma levels; observe for toxicity.
  • CYP3A4 inhibitors (e.g., ketoconazole): may modestly increase exposure; consider dose adjustment.

Frequently Asked Questions

Lenalidomid Stada contains lenalidomide, an immunomodulatory agent indicated for the treatment of multiple myeloma and for myelodysplastic syndromes that have a deletion of chromosome 5q (del‑5q). It may be used in both newly diagnosed and relapsed/refractory disease settings, often as part of combination therapy under specialist supervision.

Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering its activity. This leads to the degradation of specific transcription factors, resulting in anti‑angiogenic effects, modulation of the immune response, and direct anti‑tumor activity against malignant plasma cells and dysplastic marrow clones.

The prescribed dose of Lenalidomid Stada is individualized by the treating physician based on the patient’s diagnosis, disease stage, renal function, and prior therapies. Dosage adjustments and treatment cycles are determined by clinical guidelines and the prescriber’s judgment; patients should follow the exact regimen provided by their healthcare professional.

Lenalidomide is classified as teratogenic and may cause fetal harm; it is contraindicated in pregnancy. Both male and female patients of reproductive potential must use effective contraception during treatment and for a defined period after the last dose. Safety during breastfeeding has not been established, and nursing is generally discouraged.

To request Lenalidomid Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with traditional chemotherapy, lenalidomide offers a targeted immunomodulatory approach with oral administration. It is often combined with dexamethasone or proteasome inhibitors, providing synergistic activity. While other agents such as bortezomib or carfilzomib are administered intravenously, lenalidomide’s oral route can improve convenience but requires careful monitoring of blood counts.

Lenalidomid Stada tablets should be stored at temperatures below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discoloured.

The medication is taken orally, usually once daily on a prescribed schedule that may include treatment days followed by rest periods. Tablets should be swallowed whole with water and not crushed or chewed unless directed by a healthcare professional. Adherence to the dosing calendar is essential for optimal efficacy.

The most critical safety concerns include severe cytopenias (especially neutropenia and thrombocytopenia), venous thromboembolism, and rare but serious skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for blood count changes and signs of clotting or severe skin events, and treatment should be adjusted or discontinued as clinically indicated.

Lenalidomid Stada is contraindicated in patients with known hypersensitivity to lenalidomide or any excipients, in pregnant women, and in individuals who cannot adhere to required contraception measures. Caution is also advised for patients with severe renal impairment or uncontrolled infections, and the drug should be avoided unless the prescriber determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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