Product image of Lenalidomid Stada Nord (Lenalidomide) supplied by GNH India

Lenalidomid Stada Nord

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Stada Nord (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Stada Nord, is an immunomodulatory drug presented as an oral formulation for oral use. It is used to treat certain blood cancers, specifically multiple myeloma and myelodysplastic syndromes, in adult patients.

GNH India supplies Lenalidomid Stada Nord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant shipments to global markets.

Manufacturer / TM Owner

Stada Nordic Aps

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Indications & Clinical Uses

Lenalidomide is indicated for hematologic malignancies and related bone‑marrow disorders.

  • Multiple Myeloma (newly diagnosed): reduces disease progression and improves overall survival in adult patients.
  • Multiple Myeloma (relapsed/refractory): provides therapeutic benefit after prior treatment failure.
  • Myelodysplastic Syndromes with del(5q): decreases transfusion dependence and modifies disease course in eligible patients.

How It Works

  • Lenalidomide binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering substrate specificity and leading to degradation of transcription factors such as Ikaros and Aiolos. This results in immunomodulation, inhibition of angiogenesis, and direct anti‑proliferative effects on malignant plasma and myeloid cells, thereby suppressing tumor growth.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Thrombocytopenia: lowered platelet levels leading to bleeding tendencies.
  • Fatigue: persistent tiredness affecting daily activities.
  • Nausea: upset stomach often occurring after dosing.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Severe skin reactions: including Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Secondary primary malignancies: emergence of new cancers unrelated to the original disease.

Precautions & Warnings

Before initiating therapy, clinicians should assess baseline parameters and monitor patients regularly.

  • Blood count monitoring: perform routine CBC to detect neutropenia or thrombocytopenia.
  • Thromboembolic risk assessment: evaluate need for prophylactic anticoagulation in high‑risk patients.
  • Renal function evaluation: adjust therapy if creatinine clearance is impaired.
  • Pregnancy avoidance: ensure effective contraception and avoid use in pregnant women.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lenalidomide may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lenalidomide exposure.
  • Warfarin: concurrent use can potentiate anticoagulant effect and raise INR.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce therapeutic levels.
  • P-glycoprotein substrates (e.g., digoxin): monitor for altered plasma concentrations.
  • Other immunomodulatory agents: increased risk of hematologic toxicity.

Frequently Asked Questions

Lenalidomid Stada Nord contains lenalidomide, which is prescribed for adult patients with multiple myeloma and for those with myelodysplastic syndromes that have the del(5q) chromosomal abnormality. It helps control disease progression, reduces the need for blood transfusions, and can improve overall survival when used as part of a comprehensive treatment plan.

Lenalidomide binds to the cereblon protein within the CRL4‑CRBN ubiquitin‑ligase complex, altering the degradation of specific transcription factors such as Ikaros and Aiolos. This leads to modulation of the immune response, inhibition of new blood‑vessel formation, and direct anti‑proliferative activity against malignant plasma and myeloid cells, thereby slowing tumor growth.

The exact dosage of Lenalidomid Stada Nord is individualized by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function, and prior therapies. Healthcare providers determine the appropriate strength, frequency, and duration of treatment in accordance with approved labeling and clinical guidelines.

Lenalidomid Stada Nord is contraindicated in pregnancy because it can cause fetal harm. Women of child‑bearing potential must use effective contraception before, during, and after treatment. Safety during breastfeeding has not been established, and nursing mothers are generally advised to avoid the medication or discontinue breastfeeding while on therapy.

To request Lenalidomid Stada Nord, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Both lenalidomide and thalidomide belong to the immunomodulatory drug (IMiD) class, but lenalidomide is more potent, has a different safety profile, and is generally better tolerated. Lenalidomide shows stronger anti‑angiogenic and anti‑proliferative effects, while thalidomide is associated with higher rates of peripheral neuropathy. Choice of therapy depends on the specific disease, prior treatment history, and individual patient factors.

Store Lenalidomid Stada Nord at temperatures below 25 °C (77 °F) in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date. No special refrigeration is required for this oral formulation.

Lenalidomid Stada Nord is taken orally, usually with or without food, as directed by the prescribing physician. Tablets (or the appropriate oral dosage form) should be swallowed whole with a glass of water. Patients should follow the dosing schedule provided by their healthcare professional and not alter the regimen without medical advice.

The most serious risks include severe neutropenia or thrombocytopenia, which can lead to life‑threatening infections or bleeding, and the potential for venous thromboembolism such as deep‑vein thrombosis or pulmonary embolism. Rare but critical adverse events also encompass severe skin reactions (e.g., Stevens‑Johnson syndrome) and the development of secondary primary malignancies.

Lenalidomid Stada Nord should not be used by patients who are pregnant, have known hypersensitivity to lenalidomide or any excipients, or have uncontrolled severe infections. Caution is also advised for individuals with significant renal impairment, active thromboembolic disease, or those taking medications that may interact dangerously without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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