Product image of Lenalidomid Sun (Lenalidomide) supplied by GNH India

Lenalidomid Sun

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Sun (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Sun, is an immunomodulatory drug (IMiD) presented as an oral formulation for oral use. It is indicated for multiple myeloma, myelodysplastic syndromes with del(5q), mantle cell lymphoma, follicular lymphoma and chronic lymphocytic leukemia in appropriate patients.

GNH India supplies Lenalidomid Sun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Sun Pharmaceutical Industries Europe B.V.

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Indications & Clinical Uses

Lenalidomide is used in several hematologic malignancies and related disorders, targeting abnormal cell growth and immune dysregulation.

  • Multiple myeloma: improves response rates and prolongs survival in relapsed or refractory disease.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and cytopenias.
  • Mantle cell lymphoma: contributes to disease control when combined with other agents.
  • Follicular lymphoma: enhances remission duration in selected patients.
  • Chronic lymphocytic leukemia: adds therapeutic benefit in combination regimens.

How It Works

  • Lenalidomide binds to the cereblon subunit of the CRL4CRBN E3 ubiquitin ligase complex, altering substrate specificity. This leads to degradation of transcription factors Ikaros and Aiolos, resulting in anti‑angiogenic activity, modulation of cytokine production, enhanced natural killer and T‑cell immunity, and direct anti‑tumor effects through apoptosis and cell‑cycle arrest.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Fatigue: persistent tiredness reported by many patients.
  • Diarrhea: loose stools occurring during treatment.
  • Rash: mild skin eruptions or itching.
  • Nausea: occasional upset stomach.
  • Constipation: reduced bowel movements.
  • Peripheral neuropathy: tingling or numbness in extremities.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Severe neutropenia: markedly low white‑blood‑cell counts.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Secondary malignancies: emergence of new cancers.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiac arrhythmias: irregular heart rhythms in susceptible individuals.

Precautions & Warnings

Patients should be monitored for known risks and counseled on safety measures.

  • Pregnancy contraindication: drug is teratogenic; avoid use in pregnant women.
  • Thrombosis risk: assess need for prophylactic anticoagulation.
  • Renal impairment: adjust monitoring in patients with reduced kidney function.
  • Hepatic dysfunction: evaluate liver function before and during therapy.
  • Infection vigilance: monitor for signs of infection due to immunosuppression.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lenalidomide may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: may reduce lenalidomide exposure.
  • Anticoagulants: increased risk of bleeding when combined with lenalidomide.

Moderate Interactions (Monitor Closely)

  • Immunosuppressants: heightened infection risk.
  • P‑glycoprotein inhibitors: potential alteration of drug levels.
  • NSAIDs: may exacerbate renal toxicity.
  • Vaccines: live vaccines should be avoided during treatment.
  • Hormonal contraceptives: reduced efficacy; additional contraception recommended.

Frequently Asked Questions

Lenalidomid Sun contains lenalidomide, which is prescribed for several hematologic cancers, including multiple myeloma, myelodysplastic syndromes with del(5q), mantle cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia. It is used in patients who meet specific clinical criteria as determined by their treating physician.

Lenalidomide binds to cereblon, a component of the CRL4CRBN E3 ubiquitin ligase complex. This binding changes the complex’s substrate specificity, leading to degradation of transcription factors that regulate cell survival and immune function. The result is anti‑angiogenic activity, enhanced immune response, and direct inhibition of malignant cell growth.

The dosage of Lenalidomid Sun is individualized. The prescribing clinician determines the appropriate dose, schedule, and treatment duration based on the patient’s specific diagnosis, disease stage, renal function, and overall health status. Patients should follow the prescriber’s instructions exactly.

Lenalidomid Sun is contraindicated in pregnancy because it is teratogenic and can cause fetal harm. Women of child‑bearing potential must use effective contraception during treatment and for a defined period after the last dose. Breastfeeding is not recommended while taking lenalidomide.

To request Lenalidomid Sun, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lenalidomid Sun belongs to the immunomodulatory drug class, offering a distinct mechanism compared with proteasome inhibitors or monoclonal antibodies. It provides oral administration, immunomodulatory and anti‑angiogenic effects, and is often used in combination regimens. Choice of therapy depends on disease characteristics, prior treatments, and patient tolerance.

Lenalidomid Sun should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and store it out of reach of children. Do not refrigerate or freeze unless otherwise directed by the supplier.

Lenalidomid Sun is taken orally, usually with water. The exact dosing schedule—such as daily or on specific days of a treatment cycle—is set by the prescriber. Patients should swallow the tablet whole and not crush or split it unless instructed.

Serious risks include thromboembolic events (blood clots), severe neutropenia (low white‑blood‑cell count), hepatotoxicity (liver injury), secondary malignancies, and severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for these complications and report any concerning symptoms promptly.

Lenalidomid Sun should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with uncontrolled infections or severe renal impairment without appropriate dose adjustment. Contraindications and precautions are assessed by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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