Product image of Lenalidomid Sun (Lenalidomide) supplied by GNH India

Lenalidomid Sun

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Sun (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Sun, is an immunomodulatory imide drug (IMiD) presented as an oral tablet for oral use. It is indicated for the treatment of certain blood cancers, including multiple myeloma, myelodysplastic syndromes and mantle cell lymphoma, in adult patients with relapsed or refractory disease.

GNH India supplies Lenalidomid Sun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Sun Pharmaceutical Industries Europe B.V.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Lenalidomide is employed in hematologic malignancies that involve abnormal plasma cell or lymphoid proliferation.

  • Multiple myeloma: reduces tumor burden and prolongs progression‑free survival.
  • Myelodysplastic syndromes with del(5q): improves blood counts and reduces transfusion dependence.
  • Mantle cell lymphoma: induces remission and extends overall survival.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, altering substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), which modulates cytokine production, enhances T‑cell and natural‑killer cell activity, and inhibits angiogenesis. The combined anti‑proliferative and pro‑apoptotic actions underlie its antineoplastic effect. Additionally, it disrupts the bone marrow microenvironment, contributing to disease control.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may lead to dehydration.
  • Nausea: mild to moderate upset stomach.
  • Rash: skin redness or itching.
  • Constipation: difficulty passing stools.
  • Peripheral edema: swelling of the lower extremities.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Severe neutropenia: markedly reduced neutrophil count increasing infection risk.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Secondary primary malignancies: emergence of new cancers.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

When prescribing Lenalidomid Sun, clinicians should observe several safety considerations to minimize risk.

  • Pregnancy contraindication: avoid use in pregnancy (Category X) and ensure effective contraception.
  • Thromboembolic risk: assess patient history and consider prophylactic anticoagulation.
  • Renal impairment: adjust monitoring and dosing in patients with reduced kidney function.
  • Hepatic dysfunction: evaluate liver function before initiation and monitor regularly.
  • Infection vigilance: monitor for signs of infection due to neutropenia.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Lenalidomide can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: may reduce lenalidomide exposure (e.g., rifampin, carbamazepine).
  • Anticoagulants: increased risk of bleeding when combined with warfarin or direct oral anticoagulants.

Moderate Interactions (Monitor Closely)

  • Immunosuppressants: may enhance infection risk (e.g., cyclosporine, tacrolimus).
  • CYP2C19 inhibitors: potential modest increase in plasma levels (e.g., fluoxetine).
  • P‑glycoprotein substrates: may affect drug transport (e.g., digoxin).
  • Vaccines: live vaccines should be avoided during treatment.

Frequently Asked Questions

Lenalidomid Sun contains lenalidomide, an immunomodulatory imide drug approved for the treatment of several hematologic cancers. It is used in adult patients with multiple myeloma, myelodysplastic syndromes that have a del(5q) chromosomal abnormality, and mantle cell lymphoma, typically when disease is relapsed or refractory to other therapies.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, changing the complex’s substrate specificity. This triggers ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, leading to reduced tumor cell proliferation, increased apoptosis, enhanced immune cell activity, and inhibition of new blood‑vessel formation that supports cancer growth.

The dosing regimen for Lenalidomid Sun is individualized and must be determined by a qualified prescriber based on the specific indication, disease status, renal function, and other patient‑specific factors. Healthcare professionals follow approved labeling and clinical guidelines to set the appropriate dose and schedule.

Lenalidomid Sun is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. Women of childbearing potential must use effective contraception. The drug is also not recommended while breastfeeding, as it may be excreted in milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Lenalidomid Sun. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lenalidomide belongs to the immunomodulatory imide drug (IMiD) class, which also includes thalidomide and pomalidomide. Compared with thalidomide, lenalidomide generally has a more favorable safety profile, especially regarding peripheral neuropathy, and offers stronger anti‑angiogenic and immune‑activating effects. Pomalidomide is a newer IMiD with activity in patients who have progressed after lenalidomide, but it may carry a higher risk of hematologic toxicity.

Lenalidomid Sun tablets should be stored at ambient temperature, preferably below 25 °C (77 °F). Keep the product in its original blister pack or container, protect it from moisture, excessive heat and direct sunlight. Do not store in the bathroom or near a kitchen sink where humidity is high.

Lenalidomid Sun is administered orally as a tablet. Patients should swallow the tablet whole with a glass of water, preferably on an empty stomach unless directed otherwise by the prescriber. The exact timing relative to meals and any required dose adjustments are determined by the treating physician.

The most serious adverse events include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe neutropenia that can predispose to serious infections, and rare but life‑threatening skin reactions like Stevens‑Johnson syndrome. Regular monitoring of blood counts, liver function and vigilance for signs of clotting or infection are essential.

Lenalidomid Sun should not be used by pregnant women or women who could become pregnant without effective contraception. Patients with uncontrolled severe renal impairment, active uncontrolled infections, or a history of severe hypersensitivity to lenalidomide or any component of the formulation should avoid the drug. The prescriber must evaluate each individual’s risk before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.