Product image of Lenalidomid Sun (Lenalidomide) supplied by GNH India

Lenalidomid Sun

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Sun (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Sun, is an immunomodulatory imide drug presented as an oral formulation for oral use. It is employed in the treatment of certain blood cancers, including multiple myeloma, myelodysplastic syndromes with del(5q), mantle cell lymphoma and follicular lymphoma, and is prescribed for adult patients under specialist supervision.

GNH India supplies Lenalidomid Sun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, through full regulatory compliance and quality assurance.

Manufacturer / TM Owner

Sun Pharmaceutical Industries Europe B.V.

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Indications & Clinical Uses

Lenalidomide is used in hematologic malignancies and related bone‑marrow disorders, targeting abnormal plasma cells and dysplastic clones.

  • Multiple Myeloma: reduces disease progression, improves overall survival, and delays the need for further chemotherapy in patients with relapsed or refractory disease.
  • Myelodysplastic Syndromes with del(5q): corrects ineffective hematopoiesis, decreases transfusion dependence, and can lead to cytogenetic remission in affected patients.
  • Mantle Cell Lymphoma: induces tumor regression and prolongs progression‑free survival in patients whose disease has relapsed after prior therapy.
  • Follicular Lymphoma: provides clinical benefit by achieving partial or complete responses in relapsed or refractory cases.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering its substrate specificity. This leads to ubiquitination and proteasomal degradation of the transcription factors Ikaros and Aiolos, resulting in anti‑angiogenic, immunomodulatory, and direct anti‑tumor activities that suppress malignant plasma cells and modulate the immune microenvironment. Additionally, it enhances natural killer cell activity and cytokine production, contributing to its therapeutic effect.

Side Effects

Lenalidomide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may require fluid replacement.
  • Rash: mild skin eruptions or itching.
  • Neutropenia: reduced neutrophil count increasing infection risk.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Secondary malignancies: development of new cancers such as acute leukemia.

Precautions & Warnings

When prescribing Lenalidomide, clinicians should observe several safety precautions to minimize risks.

  • Pregnancy risk: contraindicated in pregnancy (Category X); ensure effective contraception.
  • Thrombotic risk: assess for clotting disorders and consider prophylactic anticoagulation.
  • Renal function: adjust monitoring in patients with impaired kidney function.
  • Hematologic monitoring: perform regular blood counts to detect cytopenias.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Lenalidomide interacts with several agents; awareness of these interactions helps avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: may lower lenalidomide exposure.
  • Anticoagulants (warfarin, DOACs): increase bleeding risk; monitor coagulation parameters.
  • Immunosuppressants (e.g., cyclosporine): may enhance hematologic toxicity.

Moderate Interactions (Monitor Closely)

  • P‑glycoprotein substrates: may alter plasma levels.
  • Live vaccines: risk of infection due to immunomodulation.
  • CYP450 inhibitors: potential modest increase in drug concentration.

Frequently Asked Questions

Lenalidomid Sun contains lenalidomide, which is indicated for the treatment of several hematologic cancers, including multiple myeloma, myelodysplastic syndromes with del(5q), mantle cell lymphoma and follicular lymphoma. It is used under specialist supervision to control disease progression and improve patient outcomes.

Lenalidomide binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase complex, changing its substrate specificity. This triggers ubiquitination and degradation of transcription factors Ikaros and Aiolos, leading to anti‑angiogenic, immunomodulatory, and direct anti‑tumor effects that suppress malignant plasma cells and modify the immune environment.

The specific dose of Lenalidomid Sun is determined by the treating physician based on the patient’s diagnosis, disease stage, renal function, and other clinical factors. Dosing regimens are individualized and should follow the prescriber’s instructions and local regulatory guidelines.

Lenalidomid Sun is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because it can cause fetal harm. Women of child‑bearing potential must use effective contraception. The product is also not recommended for breastfeeding mothers, as it may be excreted in milk and affect the infant.

To order Lenalidomid Sun, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lenalidomide belongs to the immunomodulatory imide drug (IMiD) class, similar to thalidomide and pomalidomide. Compared with thalidomide, lenalidomide generally shows higher potency, a more favorable safety profile, and fewer peripheral neuropathy events. Pomalidomide is a newer IMiD with activity in some lenalidomide‑refractory cases, but it may have a higher risk of hematologic toxicity.

Lenalidomid Sun should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product protected from moisture and direct light. Do not store in the bathroom or near heat sources. Follow any additional handling instructions provided with the shipment to maintain product integrity.

Lenalidomid Sun is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s guidance regarding timing relative to meals. Swallow the tablet whole; do not crush, split, or chew unless specifically instructed by a healthcare professional.

The most serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe cutaneous reactions like Stevens‑Johnson syndrome, and secondary malignancies such as acute leukemia. Patients should be monitored closely for signs of clotting, unusual skin changes, or new cancer symptoms, and report any concerns promptly to their healthcare provider.

Lenalidomid Sun should not be used by pregnant women or women who could become pregnant, because of its teratogenic potential (Category X). Patients with known hypersensitivity to lenalidomide or any component of the formulation should avoid it. Caution is also advised in individuals with severe renal impairment, uncontrolled infections, or a history of thromboembolic disease unless appropriate prophylaxis is in place.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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