Product image of Lenalidomid Teva (Lenalidomide) supplied by GNH India

Lenalidomid Teva

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Teva (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Teva, is an immunomodulatory imide drug (IMiD) presented as an oral formulation for oral use. It is employed in the treatment of certain blood cancers, including multiple myeloma, myelodysplastic syndromes with del(5q), and mantle‑cell lymphoma, typically in adult patients under specialist supervision.

GNH India supplies Lenalidomid Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lenalidomid Teva is an immunomodulatory agent used in hematologic malignancies and related disorders.

  • Multiple myeloma: helps control disease progression and improve survival when used in combination regimens.
  • Myelodysplastic syndromes with del(5q): reduces transfusion dependence and may achieve cytogenetic remission.
  • Mantle cell lymphoma: contributes to disease control as part of approved therapeutic protocols.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering substrate specificity. This leads to ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos, resulting in anti‑angiogenic, immunomodulatory, and direct anti‑proliferative effects on malignant plasma cells and related hematologic tumors.

Side Effects

Lenalidomid Teva may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Neutropenia: reduced neutrophil count increasing infection risk.
  • Thrombocytopenia: lowered platelet levels leading to bleeding tendencies.
  • Fatigue: persistent tiredness affecting daily activities.
  • Nausea: upset stomach often occurring after dosing.
  • Constipation: difficulty passing stools.
  • Rash: mild skin irritation or erythema.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Secondary primary malignancies: emergence of new cancers.
  • Tumor lysis syndrome: rapid tumor cell breakdown causing metabolic disturbances.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Hepatotoxicity: liver enzyme elevations indicating potential liver injury.

Precautions & Warnings

Before initiating therapy with Lenalidomid Teva, several safety considerations should be observed.

  • Monitor blood counts: perform regular CBC to detect cytopenias.
  • Assess renal function: adjust use in patients with impaired kidney clearance.
  • Avoid pregnancy: teratogenic risk requires strict contraception for both sexes.
  • Counsel on contraception: use effective methods throughout treatment and for a defined period after cessation.
  • Watch for thrombotic events: evaluate risk factors and consider prophylaxis when indicated.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Lenalidomid Teva can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lenalidomide exposure.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce therapeutic levels.
  • Live vaccines: risk of infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin, DOACs): heightened bleeding risk.
  • NSAIDs: may exacerbate renal toxicity.
  • Other myelosuppressive agents: additive bone‑marrow suppression.
  • ACE inhibitors or ARBs: monitor renal function and electrolytes.

Frequently Asked Questions

Lenalidomid Teva contains lenalidomide and is indicated for the treatment of multiple myeloma, myelodysplastic syndromes with a deletion of chromosome 5q, and mantle‑cell lymphoma. In each case the drug is used as part of a prescribed therapeutic regimen aimed at controlling disease activity and improving patient outcomes.

Lenalidomide binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase complex. This binding changes the complex’s substrate specificity, leading to the ubiquitination and degradation of transcription factors Ikaros and Aiolos. The resulting actions include anti‑angiogenic effects, modulation of the immune response, and direct inhibition of malignant cell proliferation.

The specific dose of Lenalidomid Teva is determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function, and other individual factors. Healthcare professionals follow approved labeling and clinical guidelines to select the appropriate dosage and schedule for each patient.

Lenalidomid Teva is classified as teratogenic and is contraindicated in pregnancy. Women of childbearing potential must use effective contraception before, during, and after treatment. Safety during breastfeeding has not been established, and breastfeeding is generally not recommended while taking lenalidomide.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lenalidomid Teva belongs to the immunomodulatory imide drug class, offering a distinct mechanism compared with proteasome inhibitors or monoclonal antibodies used in similar indications. Its oral administration and ability to target cereblon‑mediated pathways provide an alternative or complementary option, often selected based on patient tolerance, prior therapy, and specific disease characteristics.

Lenalidomid Teva should be stored at room temperature, below 25 °C, in its original packaging. The container protects the product from moisture and light, helping maintain stability throughout its shelf life.

Lenalidomid Teva is taken orally, usually with or without food, as directed by the prescribing physician. The tablets are swallowed whole with a glass of water and the dosing schedule is individualized for each patient.

The most serious risks include severe neutropenia or thrombocytopenia, which can lead to infections or bleeding, venous thromboembolism, secondary primary malignancies, and rare but life‑threatening reactions such as tumor lysis syndrome or severe hypersensitivity. Patients should be monitored closely for these events.

Lenalidomid Teva is contraindicated in patients with known hypersensitivity to lenalidomide or any component of the formulation, in pregnant women, and in individuals who cannot adhere to strict contraceptive measures. Caution is also advised for patients with severe renal impairment or uncontrolled infections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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