Product image of Lenalidomid Teva (Lenalidomide) supplied by GNH India

Lenalidomid Teva

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Teva (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Teva, is an immunomodulatory drug presented as an oral tablet for oral use. It is indicated for the treatment of certain hematologic malignancies, including multiple myeloma, myelodysplastic syndromes, and mantle cell lymphoma in adult patients.

GNH India supplies Lenalidomid Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lenalidomid Teva is an immunomodulatory agent used in the management of specific blood cancers.

  • Multiple myeloma: helps control disease progression and improve survival.
  • Myelodysplastic syndromes: reduces transfusion dependence and delays transformation to acute leukemia.
  • Mantle cell lymphoma: contributes to tumor reduction and prolongs remission.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4 E3 ubiquitin ligase complex, promoting ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos. This leads to anti‑angiogenic, immunomodulatory, and anti‑proliferative effects that disrupt malignant plasma cell growth and restore immune surveillance.

Side Effects

Lenalidomid Teva may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Fatigue: persistent tiredness.
  • Nausea: upset stomach, sometimes with vomiting.
  • Diarrhoea: loose stools.
  • Constipation: difficulty passing stool.
  • Rash: mild skin irritation.
  • Low blood counts: mild neutropenia or anaemia.

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism.
  • Severe neutropenia or leukopenia.
  • Hepatotoxicity: elevated liver enzymes.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Second primary malignancies.
  • Severe allergic reactions: anaphylaxis.

Precautions & Warnings

Before initiating therapy, clinicians should assess patient risk factors and monitor appropriately.

  • Blood count monitoring: perform complete blood counts regularly.
  • Thromboembolic risk: evaluate and consider prophylactic anticoagulation when indicated.
  • Pregnancy avoidance: prescribe effective contraception; drug is contraindicated in pregnancy.
  • Renal/hepatic function: adjust therapy based on organ function assessments.
  • Vaccination caution: avoid live vaccines during treatment.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lenalidomid Teva can interact with several medication classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce drug exposure.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding or thrombosis.
  • Live vaccines: heightened risk of infection.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase plasma levels.
  • NSAIDs: may augment thrombotic risk.
  • Digoxin: potential for altered serum concentrations.
  • Other immunomodulatory agents: additive myelosuppression risk.

Frequently Asked Questions

Lenalidomid Teva contains lenalidomide, an immunomodulatory drug approved for the treatment of multiple myeloma, myelodysplastic syndromes with del(5q), and mantle cell lymphoma. It is used in adult patients to control disease progression, reduce transfusion needs, and extend remission periods.

Lenalidomide binds to cereblon, a component of the CRL4 E3 ubiquitin ligase complex, leading to the degradation of transcription factors Ikaros and Aiolos. This action results in anti‑angiogenic, immunomodulatory, and anti‑proliferative effects that inhibit malignant cell growth and enhance immune-mediated tumor clearance.

The specific dose and schedule of Lenalidomid Teva are determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal function, and prior therapies. Healthcare providers tailor the regimen to achieve optimal therapeutic benefit while minimizing toxicity.

Lenalidomid Teva is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to a high risk of fetal harm. Women of childbearing potential must use effective contraception. The safety of the drug during breastfeeding has not been established, and nursing is generally discouraged.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

The primary alternative to lenalidomide is thalidomide, another immunomodulatory agent. Lenalidomide generally offers a more favorable safety profile, with lower rates of peripheral neuropathy, and provides stronger anti‑angiogenic activity. However, both drugs share risks such as thrombosis and myelosuppression, and the choice depends on individual patient factors.

Lenalidomid Teva should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Lenalidomid Teva is taken orally, usually as a tablet, with or without food as directed by the prescriber. Patients should swallow the tablet whole with water and follow the dosing schedule provided by their healthcare professional.

The most serious risks include deep vein thrombosis or pulmonary embolism, severe neutropenia or leukopenia that can lead to infection, hepatotoxicity, and the potential development of second primary malignancies. Prompt reporting of symptoms such as unexplained pain, fever, or unusual bleeding is essential.

Lenalidomid Teva should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, patients with uncontrolled infections, or those with severe renal or hepatic impairment without appropriate dose adjustment. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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