Product image of Lenalidomid Teva B.V. (Lenalidomide) supplied by GNH India

Lenalidomid Teva B.V.

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Teva B.V. (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Teva B.V., is a Immunomodulatory imide drug (IMiD) presented as an oral tablet for oral use. It treats multiple myeloma, myelodysplastic syndromes with del(5q), and mantle cell lymphoma in adult patients.

GNH India supplies Lenalidomid Teva B.V. as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lenalidomide is employed in hematologic malignancies that involve abnormal plasma or lymphoid cells.

  • Multiple Myeloma: improves progression‑free survival and reduces disease burden in adult patients.
  • Myelodysplastic Syndromes with del(5q): induces transfusion independence and cytogenetic remission.
  • Mantle Cell Lymphoma: provides disease control in relapsed or refractory cases.

How It Works

  • Lenalidomide binds to cereblon, a component of the CRL4‑CRBN E3 ubiquitin ligase complex, altering substrate specificity and promoting degradation of transcription factors Ikaros and Aiolos. This modulates immune cell activity, enhances T‑cell and NK‑cell responses, inhibits angiogenesis, and triggers apoptosis of malignant plasma and lymphoid cells.

Side Effects

Lenalidomide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fatigue: persistent tiredness affecting daily activities.
  • Diarrhea: loose stools that may require fluid replacement.
  • Rash: mild skin eruptions or itching.
  • Neutropenia: reduced neutrophil count increasing infection risk.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Severe cutaneous reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Secondary malignancies: development of new cancers such as acute myeloid leukemia.

Precautions & Warnings

When prescribing Lenalidomide, clinicians should observe several safety precautions.

  • Pregnancy risk: contraindicated in pregnancy (Category X); ensure effective contraception.
  • Thromboembolic prophylaxis: assess need for anticoagulation in high‑risk patients.
  • Renal impairment: adjust monitoring and dose in patients with reduced kidney function.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Infection monitoring: watch for signs of infection due to neutropenia.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Lenalidomide has known drug interactions that may alter its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may reduce plasma concentrations.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding when combined with thrombocytopenia.

Moderate Interactions (Monitor Closely)

  • P‑glycoprotein inhibitors (e.g., verapamil): may increase exposure.
  • Immunosuppressants (e.g., cyclosporine): heightened risk of infection.
  • Live vaccines: may be less effective while on therapy.

Frequently Asked Questions

Lenalidomid Teva B.V. contains lenalidomide, an immunomodulatory imide drug indicated for the treatment of multiple myeloma, myelodysplastic syndromes with the del(5q) cytogenetic abnormality, and mantle cell lymphoma in adult patients.

Lenalidomide binds to the cereblon component of the CRL4‑CRBN E3 ubiquitin ligase complex, leading to selective degradation of transcription factors Ikaros and Aiolos. This results in enhanced immune cell activity, inhibition of angiogenesis, and induction of apoptosis in malignant plasma and lymphoid cells.

The specific dose and schedule of Lenalidomid Teva B.V. are determined by the prescribing physician based on the patient’s diagnosis, disease stage, renal function, and other clinical factors. No fixed dosing information is provided here.

Lenalidomid Teva B.V. is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because of a high risk of fetal harm. Breastfeeding is not recommended, as the drug may be excreted in milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lenalidomide is a second‑generation IMiD, offering greater potency and a more favorable safety profile than thalidomide, while generally being better tolerated than the newer agent pomalidomide. Choice among these agents depends on disease‑specific factors, prior therapy, and individual patient tolerance.

Store Lenalidomid Teva B.V. at ambient temperature, preferably below 25 °C, in the original packaging. Protect the product from moisture and direct light to maintain stability throughout its shelf life.

The medication is administered orally, usually as a tablet taken with or without food, according to the prescriber’s instructions. Patients should swallow the tablet whole and follow any specific guidance regarding timing relative to meals.

Key serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe cutaneous reactions like Stevens‑Johnson syndrome, and the possible development of secondary malignancies such as acute myeloid leukemia. Prompt medical attention is required if any of these occur.

Lenalidomid Teva B.V. should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, and patients with severe renal impairment unless dose adjustments and close monitoring are implemented by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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