Product image of Lenalidomid Wh (Lenalidomide) supplied by GNH India

Lenalidomid Wh

Active Ingredient:
Lenalidomide
Origin:
EU

Lenalidomid Wh (Lenalidomide)

Lenalidomide, the active ingredient in Lenalidomid Wh, is an immunomodulatory drug presented as an oral formulation for oral use. It is employed in the treatment of certain blood cancers, including multiple myeloma, myelodysplastic syndromes and mantle cell lymphoma, in adult patients who have relapsed or refractory disease.

GNH India supplies Lenalidomid Wh as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Williams & Halls Ehf

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Indications & Clinical Uses

  • Lenalidomid Wh is an immunomodulatory antineoplastic agent indicated for specific hematologic malignancies.
  • Multiple myeloma: used in combination regimens to improve progression‑free survival in relapsed or refractory patients.
  • Myelodysplastic syndromes: indicated for patients with del(5q) cytogenetic abnormality to reduce transfusion dependence.
  • Mantle cell lymphoma: employed as part of therapy for relapsed or refractory disease to achieve disease control.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4‑E3 ubiquitin ligase complex, triggering ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos. This leads to modulation of the immune response, inhibition of angiogenesis, and direct anti‑tumor activity through apoptosis and cell‑cycle arrest in malignant plasma cells and related hematologic cancers.

Side Effects

Lenalidomid Wh may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Fatigue
  • Neutropenia
  • Thrombocytopenia
  • Diarrhea
  • Rash
  • Constipation

Serious or Rare Side Effects

  • Venous thromboembolism
  • Secondary primary malignancies
  • Severe neutropenia or infection
  • Hepatic failure or elevated transaminases
  • Severe cutaneous reactions (e.g., Stevens‑Johnson syndrome)
  • Tumor lysis syndrome

Precautions & Warnings

  • When prescribing Lenalidomid Wh, clinicians should observe several safety measures.
  • Pregnancy: contraindicated (Category X) – avoid use in pregnant women.
  • Thrombosis risk: assess patient history and consider prophylactic anticoagulation.
  • Hematologic monitoring: perform regular complete blood counts to detect cytopenias.
  • Renal impairment: adjust dosing and monitor renal function closely.
  • Drug interactions: avoid concomitant use with strong CYP3A4 inducers.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

Avoid Interactions

Lenalidomid Wh can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin): may markedly reduce lenalidomide exposure.
  • Anticoagulants such as warfarin: increased risk of bleeding.
  • Live vaccines: heightened risk of infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (e.g., aspirin): monitor for bleeding tendencies.
  • Other immunomodulatory agents: may enhance immunosuppressive effects.
  • Hepatotoxic drugs: monitor liver enzymes for additive toxicity.

Frequently Asked Questions

Lenalidomid Wh contains lenalidomide, an immunomodulatory antineoplastic drug approved for the treatment of multiple myeloma, myelodysplastic syndromes with del(5q) cytogenetic abnormality, and mantle cell lymphoma. It is used in adult patients whose disease has relapsed or is refractory to prior therapy, often as part of combination regimens to improve disease control.

Lenalidomide binds to cereblon, a component of the CRL4‑E3 ubiquitin ligase complex, leading to the targeted degradation of transcription factors Ikaros and Aiolos. This action modifies the immune environment, inhibits angiogenesis, and induces apoptosis and cell‑cycle arrest in malignant plasma cells, providing anti‑tumor activity in hematologic cancers.

The specific dose of Lenalidomid Wh is individualized by the treating physician based on the patient’s diagnosis, disease stage, renal function, and prior therapies. Prescribers determine the appropriate strength, schedule, and duration according to clinical guidelines and patient‑specific factors.

Lenalidomid Wh is classified as Pregnancy Category X, meaning it is contraindicated in pregnant women because it can cause fetal harm. Women of childbearing potential must use effective contraception. The drug is also not recommended for breastfeeding mothers, as it may be excreted in breast milk and affect the infant.

To order Lenalidomid Wh, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and assistance with import documentation.

Both lenalidomide and thalidomide belong to the immunomodulatory drug class, but lenalidomide is more potent, has a more favorable safety profile, and exhibits stronger anti‑angiogenic and immune‑stimulating effects. Lenalidomide is generally preferred for multiple myeloma and related disorders because it causes fewer peripheral neuropathy events than thalidomide.

Lenalidomid Wh should be stored at ambient temperature, preferably below 25 °C, in its original container to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in areas with high humidity or direct sunlight.

Lenalidomid Wh is taken orally, usually with or without food, as directed by the prescribing clinician. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include venous thromboembolism, severe neutropenia or infections, secondary primary malignancies, hepatic dysfunction, and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for signs of blood clots, infections, liver enzyme elevations, and any unusual skin changes.

Lenalidomid Wh should not be used by pregnant women, individuals with known hypersensitivity to lenalidomide or its excipients, patients with severe uncontrolled infections, or those with severe neutropenia or thrombocytopenia without appropriate medical supervision. Caution is also advised in patients with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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